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    KDM2B lysine demethylase 2B [ Bos taurus (cattle) ]

    Gene ID: 614487, updated on 5-Mar-2024

    Summary

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    Official Symbol
    KDM2Bprovided by VGNC
    Official Full Name
    lysine demethylase 2Bprovided by VGNC
    Primary source
    VGNC:VGNC:30524
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    FBXL10
    Orthologs
    human mouse all
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    Genomic context

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    See KDM2B in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (53650993..53769702)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene ORAI calcium release-activated calcium modulator 1 Neighboring gene uncharacterized LOC132342615 Neighboring gene ring finger protein 34 Neighboring gene tetraspanin-33-like Neighboring gene anaphase promoting complex subunit 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KDM2B is implicated in bovine lethal multi-organic developmental dysplasia. Testoni S, et al. PLoS One, 2012. PMID 23029151, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. genetic makeup of three inbred cattle strongly supports the causality of the KDM2B mutation
      Title: KDM2B is implicated in bovine lethal multi-organic developmental dysplasia.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein demethylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysine-specific demethylase 2B
    Names
    F-box and leucine-rich repeat protein 10
    XP_005218040.1
    XP_005218042.1
    XP_024833479.1
    XP_059732356.1
    XP_059732357.1
    XP_059732358.1
    XP_059732359.1
    XP_059732360.1
    XP_059732361.1
    XP_059732362.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      53650993..53769702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059876377.1 → XP_059732360.1  lysine-specific demethylase 2B isoform X5

    2. XM_059876375.1 → XP_059732358.1  lysine-specific demethylase 2B isoform X3

    3. XM_005217983.5 → XP_005218040.1  lysine-specific demethylase 2B isoform X6

      See identical proteins and their annotated locations for XP_005218040.1

      Conserved Domains (7) summary
      cd09293
      Location:1091 → 1280
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151 → 226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam02008
      Location:588 → 624
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:1075 → 1099
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:634 → 695
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:1041 → 1081
      F-box-like; F-box-like
      cl21464
      Location:198 → 304
      cupin_like; Conserved domain found in cupin and related proteins

    4. XM_059876376.1 → XP_059732359.1  lysine-specific demethylase 2B isoform X4

    5. XM_005217985.2 → XP_005218042.1  lysine-specific demethylase 2B isoform X7

      See identical proteins and their annotated locations for XP_005218042.1

      Conserved Domains (7) summary
      cd09293
      Location:1085 → 1274
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:145 → 220
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam02008
      Location:582 → 618
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:1069 → 1093
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:628 → 689
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:1035 → 1075
      F-box-like; F-box-like
      cl21464
      Location:192 → 298
      cupin_like; Conserved domain found in cupin and related proteins

    6. XM_059876373.1 → XP_059732356.1  lysine-specific demethylase 2B isoform X1

    7. XM_059876374.1 → XP_059732357.1  lysine-specific demethylase 2B isoform X2

    8. XM_059876379.1 → XP_059732362.1  lysine-specific demethylase 2B isoform X8

    9. XM_024977711.2 → XP_024833479.1  lysine-specific demethylase 2B isoform X9

      Conserved Domains (6) summary
      pfam02008
      Location:388 → 424
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:875 → 899
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:434 → 495
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:841 → 879
      F-box-like
      cl21464
      Location:1 → 104
      cupin_like; Conserved domain found in cupin and related proteins
      cl28166
      Location:891 → 1080
      AMN1; Antagonist of mitotic exit network protein 1

    10. XM_059876378.1 → XP_059732361.1  lysine-specific demethylase 2B isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version

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