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    CNGB1 cyclic nucleotide gated channel subunit beta 1 [ Bos taurus (cattle) ]

    Gene ID: 281702, updated on 6-Jun-2024

    Summary

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    Official Symbol
    CNGB1provided by VGNC
    Official Full Name
    cyclic nucleotide gated channel subunit beta 1provided by VGNC
    Primary source
    VGNC:VGNC:27501
    See related
    BGD:BT26294; Ensembl:ENSBTAG00000005702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CNG4; GARP
    Orthologs
    human mouse all
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    Genomic context

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    See CNGB1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (25813830..25882542, complement)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene kinesin family member C3 Neighboring gene uncharacterized LOC112442291 Neighboring gene uncharacterized LOC132342813 Neighboring gene uncharacterized LOC132342814 Neighboring gene testis, prostate and placenta expressed Neighboring gene zinc finger protein 319

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties. Pentia DC, et al. J Biol Chem, 2006 Mar 3. PMID 16407240, Free PMC Article
    2. Cyclic nucleotide-gated channels on the flagellum control Ca2+ entry into sperm. Wiesner B, et al. J Cell Biol, 1998 Jul 27. PMID 9679145, Free PMC Article
    3. Primary structure and expression of the human beta-subunit and related proteins of the rod photoreceptor cGMP-gated channel. Colville CA, et al. J Biol Chem, 1996 Dec 20. PMID 8955140
    4. Molecular cloning and expression of the Modulatory subunit of the cyclic nucleotide-gated cation channel. Biel M, et al. J Biol Chem, 1996 Mar 15. PMID 8626431
    5. A 240 kDa protein represents the complete beta subunit of the cyclic nucleotide-gated channel from rod photoreceptor. Körschen HG, et al. Neuron, 1995 Sep. PMID 7546742

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods.
      Title: The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods.
    2. Three CNGA1 subunits and a single CNGB1 subunit form the rod cyclic nucleotide-gated ion channels.
      Title: Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels.
    3. Glutamic acid-rich proteins could provide the environment needed for protein interactions in the rim region of optic discs.
      Title: Glutamic acid-rich proteins of rod photoreceptors are natively unfolded.
    4. Results suggest a novel role for glutamic acid-rich protein-2 as a regulator of spontaneous activation of rod photoreceptor phosphodiesterase, allowing rods to operate at the single photon detection limit.
      Title: The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cGMP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables intracellularly cAMP-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables intracellularly cGMP-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in retina homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic nucleotide-gated cation channel beta-1
    Names
    240 kDa protein of rod photoreceptor CNG-channel
    CNG channel 4
    CNG channel beta-1
    cyclic nucleotide gated channel beta 1
    cyclic nucleotide-gated cation channel 4
    cyclic nucleotide-gated cation channel gamma
    cyclic nucleotide-gated cation channel modulatory subunit
    glutamic-acid-rich protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135640.1 → NP_001129112.1  cyclic nucleotide-gated cation channel beta-1 isoform b

      See identical proteins and their annotated locations for NP_001129112.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon and lacks the 3' coding region, compared to variant 1. The resulting isoform (b), also known as GARP1, is much shorter and has a unique C-terminus, compared to isoform a.
      Source sequence(s)
      DV894380, M61185
      UniProtKB/TrEMBL
      G3MXC9
      Related
      ENSBTAP00000054194.1, ENSBTAT00000064172.3
      Conserved Domains (1) summary
      pfam06566
      Location:49 → 209
      Chon_Sulph_att; Chondroitin sulphate attachment domain

    2. NM_001135641.1 → NP_001129113.1  cyclic nucleotide-gated cation channel beta-1 isoform c

      See identical proteins and their annotated locations for NP_001129113.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate exon and lacks the 3' coding region, compared to variant 1. The resulting isoform (c), also known as GARP2, is much shorter and has a unique C-terminus, compared to isoform a.
      Source sequence(s)
      AF197535, M61185
      UniProtKB/TrEMBL
      G3N0A4, Q9TTT9
      Related
      ENSBTAP00000055261.1, ENSBTAT00000065243.3

    3. NM_181019.2 → NP_851362.1  cyclic nucleotide-gated cation channel beta-1 isoform a

      See identical proteins and their annotated locations for NP_851362.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      X89626
      UniProtKB/Swiss-Prot
      Q03861, Q28082, Q28181
      UniProtKB/TrEMBL
      A0AAA9U2S0
      Related
      ENSBTAP00000103951.1, ENSBTAT00000102381.1
      Conserved Domains (3) summary
      COG0664
      Location:1070 → 1203
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:1076 → 1185
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:788 → 995
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      25813830..25882542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28181.1 GenPept UniProtKB/Swiss-Prot:Q28181

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials