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    Nasp nuclear autoantigenic sperm protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298441, updated on 2-May-2024

    Summary

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    Official Symbol
    Naspprovided by RGD
    Official Full Name
    nuclear autoantigenic sperm proteinprovided by RGD
    Primary source
    RGD:1359609
    See related
    Ensembl:ENSRNOG00000016454 AllianceGenome:RGD:1359609
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone binding activity. Involved in male gonad development and response to testosterone. Predicted to be located in chromatin; cytoplasm; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Orthologous to human NASP (nuclear autoantigenic sperm protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 602.7), Thymus (RPKM 232.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nasp in Genome Data Viewer
    Location:
    5q35
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135294599..135319992, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130057363..130083003, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135446485..135472113, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 69 Neighboring gene GC-rich promoter binding protein 1-like 1 Neighboring gene coiled-coil domain containing 17 Neighboring gene aldo-keto reductase family 1 member A1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134486971

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells. Stanton PG, et al. PLoS One, 2012. PMID 22860010, Free PMC Article
    2. The antibody against a nuclear autoantigenic sperm protein can result in reproductive failure. Wang M, et al. Asian J Androl, 2009 Mar. PMID 19219058, Free PMC Article
    3. Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation. Richardson RT, et al. J Biol Chem, 2006 Jul 28. PMID 16728391
    4. Overexpression of the Linker histone-binding protein tNASP affects progression through the cell cycle. Alekseev OM, et al. J Biol Chem, 2003 Mar 7. PMID 12509435
    5. Analysis of the expression of human tumor antigens in ovarian cancer tissues. Ali-Fehmi R, et al. Cancer Biomark, 2010. PMID 20164540, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. an increase of miR-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development.
      Title: MicroRNA-29a inhibited epididymal epithelial cell proliferation by targeting nuclear autoantigenic sperm protein (NASP).
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93869

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone chaperone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone chaperone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication-dependent chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA replication-dependent chromatin assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication-dependent chromatin assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA replication-dependent chromatin assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA replication-dependent chromatin assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blastocyst development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to testosterone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear autoantigenic sperm protein
    Names
    nuclear autoantigenic sperm protein (histone-binding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005543.1 → NP_001005543.1  nuclear autoantigenic sperm protein

      See identical proteins and their annotated locations for NP_001005543.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081913
      UniProtKB/Swiss-Prot
      Q66HD3
      UniProtKB/TrEMBL
      A0A8I5ZLB9, A6JZ86
      Related
      ENSRNOP00000022170.4, ENSRNOT00000022170.6
      Conserved Domains (4) summary
      COG5271
      Location:130 → 493
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      sd00006
      Location:530 → 558
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:528 → 604
      TPR_12; Tetratricopeptide repeat
      pfam10516
      Location:530 → 567
      SHNi-TPR

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      135294599..135319992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238646.5 → XP_006238708.1  nuclear autoantigenic sperm protein isoform X1

      See identical proteins and their annotated locations for XP_006238708.1

      UniProtKB/Swiss-Prot
      Q66HD3
      UniProtKB/TrEMBL
      A0A8I5ZLB9, A6JZ86
      Conserved Domains (4) summary
      COG5271
      Location:130 → 493
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      sd00006
      Location:530 → 558
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:528 → 604
      TPR_12; Tetratricopeptide repeat
      pfam10516
      Location:530 → 567
      SHNi-TPR

    2. XM_008763993.4 → XP_008762215.1  nuclear autoantigenic sperm protein isoform X1

      See identical proteins and their annotated locations for XP_008762215.1

      UniProtKB/Swiss-Prot
      Q66HD3
      UniProtKB/TrEMBL
      A0A8I5ZLB9, A6JZ86
      Conserved Domains (4) summary
      COG5271
      Location:130 → 493
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      sd00006
      Location:530 → 558
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:528 → 604
      TPR_12; Tetratricopeptide repeat
      pfam10516
      Location:530 → 567
      SHNi-TPR

    3. XM_063287408.1 → XP_063143478.1  nuclear autoantigenic sperm protein isoform X1

      UniProtKB/Swiss-Prot
      Q66HD3
      UniProtKB/TrEMBL
      A6JZ86

    4. XM_063287407.1 → XP_063143477.1  nuclear autoantigenic sperm protein isoform X1

      UniProtKB/Swiss-Prot
      Q66HD3
      UniProtKB/TrEMBL
      A6JZ86

    5. XM_006238647.5 → XP_006238709.1  nuclear autoantigenic sperm protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZP00, A0A8I6AFA6, A6JZ85
      Related
      ENSRNOP00000091359.1
      Conserved Domains (3) summary
      sd00006
      Location:203 → 231
      TPR; TPR repeat [structural motif]
      pfam10516
      Location:203 → 240
      SHNi-TPR; SHNi-TPR
      pfam13424
      Location:200 → 277
      TPR_12; Tetratricopeptide repeat

    6. XM_063287409.1 → XP_063143479.1  nuclear autoantigenic sperm protein isoform X1

      UniProtKB/Swiss-Prot
      Q66HD3
      UniProtKB/TrEMBL
      A6JZ86
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HD3.1 GenPept UniProtKB/Swiss-Prot:Q66HD3

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