SLC2A12 solute carrier family 2 member 12 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC2A12provided by HGNC
Official Full Name: solute carrier family 2 member 12provided by HGNC
Primary source: HGNC:HGNC:18067
See related: Ensembl:ENSG00000146411 MIM:610372; AllianceGenome:HGNC:18067
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GLUT8; GLUT12
Summary: SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]
Expression: Broad expression in prostate (RPKM 9.5), endometrium (RPKM 4.6) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q23.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (133987581..134052624, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (135175590..135240550, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (134308719..134373762, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12.
Title: Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12.
Inhibition of androgen receptor enhanced the anticancer effects of everolimus through targeting glucose transporter 12.
Title: Inhibition of androgen receptor enhanced the anticancer effects of everolimus through targeting glucose transporter 12.
Epithelial mesenchymal transition regulator TWIST1 transcription factor stimulates glucose uptake through upregulation of GLUT1, GLUT3, and GLUT12 in vitro.
Title: Epithelial mesenchymal transition regulator TWIST1 transcription factor stimulates glucose uptake through upregulation of GLUT1, GLUT3, and GLUT12 in vitro.
Let-7a-5p inhibits triple-negative breast tumor growth and metastasis through GLUT12-mediated warburg effect.
Title: Let-7a-5p inhibits triple-negative breast tumor growth and metastasis through GLUT12-mediated warburg effect.
Alternative Splicing and Cleavage of GLUT8.
Title: Alternative Splicing and Cleavage of GLUT8.
We hypothesize that GLUT12 would contribute to modulate sugar absorption in physiological and pathophysiological situations such as obesity.
Title: GLUT12 and adipose tissue: Expression, regulation and its relation with obesity in mice.
GLUT12 rapid translocation to the enterocytes apical membrane in response to glucose and insulin could be related to GLUT12 participation in sugar absorption during postprandial periods. In the pathological condition of obesity, in which insulin sensitivity is reduced, the contribution of GLUT12 to sugar absorption would be affected.
Title: GLUT12 expression and regulation in murine small intestine and human Caco-2 cells.
GLUT12-knockdown completely abrogated high glucose-induced migration, indicating that GLUT12 functionally participates in sensing high glucose concentrations.
Title: Potential Roles of GLUT12 for Glucose Sensing and Cellular Migration in MCF-7 Human Breast Cancer Cells Under High Glucose Conditions.
GLUT12 is a versatile transporter: it transports a wide diversity of hexoses, it can work as a Na+ or H+/glucose symporter, and it shows electrogenic properties.
Title: Functional characterization of the human facilitative glucose transporter 12 (GLUT12) by electrophysiological methods.
findings show the level of expression of GLUT12 was significantly higher in Alzheimer's disease compare to aged controls
Title: Expression of the glucose transporter GLUT12 in Alzheimer's disease patients.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N20817 (e-PCR)
- UniSTS:70160

RH46699 (e-PCR)
- UniSTS:24694

NoName (e-PCR)
- UniSTS:481214

SHGC-146189 (e-PCR)
- UniSTS:175068

WI-14629 (e-PCR)
- UniSTS:49407

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	TAS Traceable Author Statement more info
enables glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in circulatory system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in hexose transmembrane transport	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 12

Names: GLUT-12; glucose transporter type 12; solute carrier family 2 (facilitated glucose transporter), member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145176.3 → NP_660159.1 solute carrier family 2, facilitated glucose transporter member 12

See identical proteins and their annotated locations for NP_660159.1

Status: VALIDATED

Source sequence(s)

AL035699, AL833602, AY046419, DB253903

Consensus CDS

CCDS5169.1

UniProtKB/Swiss-Prot

B3KV17, Q7Z6U3, Q8TD20, Q96MR8

Related

ENSP00000275230.5, ENST00000275230.6

Conserved Domains (1) summary

pfam00083
Location:44 → 561

Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

133987581..134052624 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017010311.3 → XP_016865800.1 solute carrier family 2, facilitated glucose transporter member 12 isoform X2
XM_006715349.5 → XP_006715412.1 solute carrier family 2, facilitated glucose transporter member 12 isoform X1

Conserved Domains (2) summary

cd06174
Location:45 → 363

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

COG0477
Location:43 → 371

ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

135175590..135240550 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054354352.1 → XP_054210327.1 solute carrier family 2, facilitated glucose transporter member 12 isoform X2
XM_054354351.1 → XP_054210326.1 solute carrier family 2, facilitated glucose transporter member 12 isoform X1