Wdsub1 WD repeat, SAM and U-box domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdsub1provided by MGI
Official Full Name: WD repeat, SAM and U-box domain containing 1provided by MGI
Primary source: MGI:MGI:1919387
See related: Ensembl:ENSMUSG00000026988 AllianceGenome:MGI:1919387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700048E19Rik; 2610014F08Rik
Summary: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Orthologous to human WDSUB1 (WD repeat, sterile alpha motif and U-box domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 11.5), ovary adult (RPKM 11.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1; 2 34.14 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (59682708..59714700, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (59852364..59882620, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment.
Title: Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: WD repeat, SAM and U-box domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159636.1 → NP_001153108.1 WD repeat, SAM and U-box domain-containing protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

BC050792, BY067767

Consensus CDS

CCDS50589.1

UniProtKB/TrEMBL

A2AUX8

Related

ENSMUSP00000099812.3, ENSMUST00000102751.9

Conserved Domains (6) summary

cd09505
Location:326 → 397

SAM_WDSUB1; SAM domain of WDSUB1 proteins

smart00454
Location:328 → 393

SAM; Sterile alpha motif

COG2319
Location:2 → 307

WD40; WD40 repeat [General function prediction only]

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

cl17238
Location:402 → 422

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_001379395.1 → NP_001366324.1 WD repeat, SAM and U-box domain-containing protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3), as well as variants 1, 4, and 5, encodes isoform 1.

Source sequence(s)

AL929242

UniProtKB/Swiss-Prot

Q80X63, Q9D0I6

Conserved Domains (4) summary

cd09505
Location:326 → 397

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:402 → 474

U-box; U-box domain
NM_001379396.1 → NP_001366325.1 WD repeat, SAM and U-box domain-containing protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (4), as well as variants 1, 3, and 5, encodes isoform 1.

Source sequence(s)

AL929242

UniProtKB/Swiss-Prot

Q80X63, Q9D0I6

Conserved Domains (4) summary

cd09505
Location:326 → 397

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:402 → 474

U-box; U-box domain
NM_001379397.1 → NP_001366326.1 WD repeat, SAM and U-box domain-containing protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (5), as well as variants 1, 3, and 4, encodes isoform 1.

Source sequence(s)

AL929242

UniProtKB/Swiss-Prot

Q80X63, Q9D0I6

Conserved Domains (4) summary

cd09505
Location:326 → 397

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:402 → 474

U-box; U-box domain
NM_001379398.1 → NP_001366327.1 WD repeat, SAM and U-box domain-containing protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (6), as well as variants 7-9, encodes the longest isoform (3).

Source sequence(s)

AL929242

Conserved Domains (4) summary

cd09505
Location:327 → 398

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:403 → 475

U-box; U-box domain
NM_001379399.1 → NP_001366328.1 WD repeat, SAM and U-box domain-containing protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (7), as well as variants 6, 8, and 9, encodes the longest isoform (3).

Source sequence(s)

AL929242

Conserved Domains (4) summary

cd09505
Location:327 → 398

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:403 → 475

U-box; U-box domain
NM_001379401.1 → NP_001366330.1 WD repeat, SAM and U-box domain-containing protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (8), as well as variants 6, 7, and 9, encodes the longest isoform (3).

Source sequence(s)

AL929242

Conserved Domains (4) summary

cd09505
Location:327 → 398

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:403 → 475

U-box; U-box domain
NM_001379402.1 → NP_001366331.1 WD repeat, SAM and U-box domain-containing protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (9), as well as variants 6-8, encodes the longest isoform (3).

Source sequence(s)

AL929242

Conserved Domains (4) summary

cd09505
Location:327 → 398

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:403 → 475

U-box; U-box domain
NM_001379404.1 → NP_001366333.1 WD repeat, SAM and U-box domain-containing protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL929242

Conserved Domains (4) summary

cd09505
Location:158 → 229

SAM_WDSUB1; SAM domain of WDSUB1 proteins

sd00039
Location:15 → 67

7WD40; WD40 repeat [structural motif]

pfam04564
Location:234 → 306

U-box; U-box domain

cl29593
Location:1 → 144

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001379405.1 → NP_001366334.1 WD repeat, SAM and U-box domain-containing protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL929242

Conserved Domains (2) summary

cd00200
Location:3 → 256

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]
NM_028118.2 → NP_082394.1 WD repeat, SAM and U-box domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_082394.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform (1). Variants 1 and 3-5 all encode the same isoform (1).

Source sequence(s)

AK011391, BY067767, CD741878

Consensus CDS

CCDS16055.1

UniProtKB/Swiss-Prot

Q80X63, Q9D0I6

Related

ENSMUSP00000028368.8, ENSMUST00000028368.14

Conserved Domains (4) summary

cd09505
Location:326 → 397

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:402 → 474

U-box; U-box domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

59682708..59714700 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500218.5 → XP_006500281.1 WD repeat, SAM and U-box domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006500281.1

Conserved Domains (4) summary

cd09505
Location:327 → 398

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:403 → 475

U-box; U-box domain
XM_006500225.4 → XP_006500288.1 WD repeat, SAM and U-box domain-containing protein 1 isoform X4

Conserved Domains (4) summary

cd09505
Location:158 → 229

SAM_WDSUB1; SAM domain of WDSUB1 proteins

sd00039
Location:15 → 67

7WD40; WD40 repeat [structural motif]

pfam04564
Location:234 → 306

U-box; U-box domain

cl29593
Location:1 → 144

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036162587.1 → XP_036018480.1 WD repeat, SAM and U-box domain-containing protein 1 isoform X2

UniProtKB/Swiss-Prot

Q80X63, Q9D0I6

Conserved Domains (4) summary

cd09505
Location:326 → 397

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:402 → 474

U-box; U-box domain
XM_006500217.5 → XP_006500280.1 WD repeat, SAM and U-box domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006500280.1

Conserved Domains (4) summary

cd09505
Location:327 → 398

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:403 → 475

U-box; U-box domain
XM_006500216.5 → XP_006500279.1 WD repeat, SAM and U-box domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006500279.1

Conserved Domains (4) summary

cd09505
Location:327 → 398

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:403 → 475

U-box; U-box domain
XM_006500222.5 → XP_006500285.1 WD repeat, SAM and U-box domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006500285.1

Conserved Domains (4) summary

cd09505
Location:327 → 398

SAM_WDSUB1; SAM domain of WDSUB1 proteins

cd00200
Location:4 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]

pfam04564
Location:403 → 475

U-box; U-box domain
XM_011239786.3 → XP_011238088.1 WD repeat, SAM and U-box domain-containing protein 1 isoform X3

See identical proteins and their annotated locations for XP_011238088.1

Conserved Domains (2) summary

cd00200
Location:3 → 264

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:16 → 52

7WD40; WD40 repeat [structural motif]