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    RBMS2 RNA binding motif single stranded interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 5939, updated on 3-Apr-2024

    Summary

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    Official Symbol
    RBMS2provided by HGNC
    Official Full Name
    RNA binding motif single stranded interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:9909
    See related
    Ensembl:ENSG00000076067 MIM:602387; AllianceGenome:HGNC:9909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCR3
    Summary
    The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lung (RPKM 17.5), placenta (RPKM 15.2) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q13.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56520405..56596193)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56488069..56564187)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56915604..56989977)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6502 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4559 Neighboring gene glutaminase 2 Neighboring gene small nucleolar RNA, H/ACA box 105C Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56916039-56916782 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56959127-56959665 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56959666-56960203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6503 Neighboring gene RNA, U6 small nuclear 343, pseudogene Neighboring gene bromodomain adjacent to zinc finger domain 2A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:57020987-57021488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6505 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:57029126-57029638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6509 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:57030665-57031176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:57038866-57039576 Neighboring gene ATP synthase F1 subunit beta Neighboring gene small nucleolar RNA, C/D box 59B Neighboring gene small nucleolar RNA, C/D box 59A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RBMS2 inhibits the proliferation by stabilizing P21 mRNA in breast cancer. Sun X, et al. J Exp Clin Cancer Res, 2018 Dec 4. PMID 30514345, Free PMC Article
    2. SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins. Kanaoka Y, et al. Nucleic Acids Res, 1994 Jul 11. PMID 8041632, Free PMC Article
    3. Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes. Skerka C, et al. J Immunol, 1992 May 15. PMID 1533657
    4. Identification of long stress-induced non-coding transcripts that have altered expression in cancer. Silva JM, et al. Genomics, 2010 Jun. PMID 20214974
    5. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. Dastani Z, et al. PLoS Genet, 2012. PMID 22479202, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39093, FLJ40023, FLJ43262

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding motif, single-stranded-interacting protein 2
    Names
    suppressor of CDC2 with RNA-binding motif 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414459.1 → NP_001401388.1  RNA-binding motif, single-stranded-interacting protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC090681, AC097104

    2. NM_001414460.1 → NP_001401389.1  RNA-binding motif, single-stranded-interacting protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC090681, AC097104

    3. NM_001414461.1 → NP_001401390.1  RNA-binding motif, single-stranded-interacting protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC090681, AC097104
      UniProtKB/Swiss-Prot
      Q15434

    4. NM_002898.4 → NP_002889.1  RNA-binding motif, single-stranded-interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_002889.1

      Status: REVIEWED

      Source sequence(s)
      AC090681, AC097104, BC027863, CF890834, DC382164
      Consensus CDS
      CCDS8923.1
      UniProtKB/Swiss-Prot
      Q15434
      UniProtKB/TrEMBL
      F8W1T6
      Related
      ENSP00000262031.5, ENST00000262031.10
      Conserved Domains (2) summary
      cd12474
      Location:135 → 220
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
      cl17169
      Location:49 → 134
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      56520405..56596193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449115.2 → XP_024304883.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X5

      Conserved Domains (2) summary
      cd12470
      Location:19 → 104
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:105 → 190
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    2. XM_005269059.6 → XP_005269116.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X3

      Conserved Domains (2) summary
      cd12470
      Location:49 → 134
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:135 → 220
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    3. XM_011538639.3 → XP_011536941.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X8

      Conserved Domains (2) summary
      cd12474
      Location:135 → 220
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
      cl17169
      Location:49 → 134
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_005269060.6 → XP_005269117.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X7

      Conserved Domains (2) summary
      cd12470
      Location:49 → 134
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:135 → 220
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    5. XM_047429297.1 → XP_047285253.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

    6. XM_006719541.5 → XP_006719604.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

      Conserved Domains (2) summary
      cd12470
      Location:49 → 134
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:135 → 220
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    7. XM_006719542.5 → XP_006719605.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X4

      Conserved Domains (2) summary
      cd12470
      Location:49 → 134
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:135 → 220
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    8. XM_005269066.5 → XP_005269123.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X10

      Conserved Domains (1) summary
      cl17169
      Location:49 → 134
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. XM_024449116.2 → XP_024304884.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X5

      Conserved Domains (2) summary
      cd12470
      Location:19 → 104
      RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
      cd12474
      Location:105 → 190
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    10. XM_047429298.1 → XP_047285254.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X6

    11. XM_011538642.4 → XP_011536944.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X9

      See identical proteins and their annotated locations for XP_011536944.1

      Conserved Domains (1) summary
      cd12474
      Location:10 → 95
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      56488069..56564187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372813.1 → XP_054228788.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X5

    2. XM_054372811.1 → XP_054228786.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X3

    3. XM_054372817.1 → XP_054228792.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X8

    4. XM_054372816.1 → XP_054228791.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X7

    5. XM_054372810.1 → XP_054228785.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

    6. XM_054372809.1 → XP_054228784.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

    7. XM_054372812.1 → XP_054228787.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X4

    8. XM_054372819.1 → XP_054228794.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X10

    9. XM_054372814.1 → XP_054228789.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X5

    10. XM_054372815.1 → XP_054228790.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X6

    11. XM_054372818.1 → XP_054228793.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15434.1 GenPept UniProtKB/Swiss-Prot:Q15434

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