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    PTGER4 prostaglandin E receptor 4 [ Canis lupus familiaris (dog) ]

    Gene ID: 403589, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PTGER4provided by VGNC
    Official Full Name
    prostaglandin E receptor 4provided by VGNC
    Primary source
    VGNC:VGNC:45144
    See related
    Ensembl:ENSCAFG00845002906
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PTGER4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (69169559..69182795, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (68339460..68352693, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (69581192..69594491, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (68929030..68942269, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (69042114..69055368, complement)

    Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene protein kinase AMP-activated catalytic subunit alpha 1 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene uncharacterized LOC111095729 Neighboring gene uncharacterized LOC119871644

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of gene expression of prostaglandin EP4 receptor in canine osteosarcoma. Musser ML, et al. Can J Vet Res, 2021 Jan. PMID 33390656, Free PMC Article
    2. Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor. Dutton LC, et al. Sci Rep, 2018 Sep 6. PMID 30190508, Free PMC Article
    3. Cardiohemodynamic and electrophysiological effects of a selective EP4 receptor agonist ONO--AE1--329 in the halothane-anesthetized dogs. Nomura H, et al. Eur J Pharmacol, 2015 Aug 15. PMID 26073024
    4. Molecular cloning and functional characterization of the canine prostaglandin E2 receptor EP4 subtype. Castleberry TA, et al. Prostaglandins Other Lipid Mediat, 2001 Jul. PMID 11444589
    5. Canine prostaglandin E2 synthase (PGES) and its receptors (EP2 and EP4): expression in the corpus luteum during dioestrus. Kowalewski MP, et al. Anim Reprod Sci, 2008 Dec. PMID 18280063

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of gene expression of prostaglandin EP4 receptor in canine osteosarcoma.
      Title: Analysis of gene expression of prostaglandin EP4 receptor in canine osteosarcoma.
    2. Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor.
      Title: Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor.
    3. Suggest that EP4 receptor stimulation can become an alternative strategy for the treatment of congestive heart failure.
      Title: Cardiohemodynamic and electrophysiological effects of a selective EP4 receptor agonist ONO--AE1--329 in the halothane-anesthetized dogs.
    4. In situ hybridization co-localizes EP2 and EP4 in the cytoplasm of the luteal cells during diestrys.
      Title: Canine prostaglandin E2 synthase (PGES) and its receptors (EP2 and EP4): expression in the corpus luteum during dioestrus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables prostaglandin E receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to prostaglandin E stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prostaglandin E2 receptor EP4 subtype
    Names
    prostaglandin E receptor 4 (subtype EP4)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003054.1 → NP_001003054.1  prostaglandin E2 receptor EP4 subtype

      See identical proteins and their annotated locations for NP_001003054.1

      Status: PROVISIONAL

      Source sequence(s)
      AF177934
      UniProtKB/TrEMBL
      A0A8C0KGL8, A0A8C0M453, Q9TU16
      Related
      ENSCAFP00845004095.1, ENSCAFT00845005156.1
      Conserved Domains (1) summary
      cd15142
      Location:18 → 347
      7tmA_PGE2_EP4; prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051808.1 Reference ROS_Cfam_1.0

      Range
      69169559..69182795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038662198.1 → XP_038518126.1  prostaglandin E2 receptor EP4 subtype isoform X1

      UniProtKB/TrEMBL
      A0A8C0KGL8, A0A8C0M453, Q9TU16
      Conserved Domains (1) summary
      cd15142
      Location:18 → 347
      7tmA_PGE2_EP4; prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049264.1 Alternate UMICH_Zoey_3.1

      Range
      68929030..68942269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

      Range
      69042114..69055368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

      Range
      69581192..69594491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      68339460..68352693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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