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    NR1I2 nuclear receptor subfamily 1 group I member 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 403482, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NR1I2provided by VGNC
    Official Full Name
    nuclear receptor subfamily 1 group I member 2provided by VGNC
    Primary source
    VGNC:VGNC:53079
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    PXR
    Orthologs
    human mouse all
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    Genomic context

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    See NR1I2 in Genome Data Viewer
    Location:
    chromosome: 33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 33 NC_051837.1 (23682177..23694192)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 33 NC_006615.4 (23474457..23486487)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 33 NC_049293.1 (23486165..23498350)

    Chromosome 33 - NC_051837.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 91 Neighboring gene methylsterol monooxygenase 1-like Neighboring gene uncharacterized LOC106558176 Neighboring gene 60S ribosomal protein L27a-like Neighboring gene glycogen synthase kinase 3 beta Neighboring gene small nucleolar RNA U3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation. Pinne M, et al. PLoS One, 2016. PMID 27732639, Free PMC Article
    2. Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Moore LB, et al. Mol Endocrinol, 2002 May. PMID 11981033

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    nuclear receptor subfamily 1 group I member 2
    Names
    pregnane X receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051837.1 Reference ROS_Cfam_1.0

      Range
      23682177..23694192
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038445374.1 → XP_038301302.1  nuclear receptor subfamily 1 group I member 2 isoform X1

      Conserved Domains (2) summary
      cd06934
      Location:524 → 809
      NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
      cl02596
      Location:411 → 508
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049293.1 Alternate UMICH_Zoey_3.1

      Range
      23486165..23498350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038519634.1 → XP_038375562.1  nuclear receptor subfamily 1 group I member 2 isoform X2

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006615.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      23474457..23486487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038462516.1 → XP_038318444.1  nuclear receptor subfamily 1 group I member 2 isoform X3

      Conserved Domains (2) summary
      cd06934
      Location:552 → 837
      NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
      cl02596
      Location:439 → 536
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version

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