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    GSK3B glycogen synthase kinase 3 beta [ Canis lupus familiaris (dog) ]

    Gene ID: 478575, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GSK3Bprovided by VGNC
    Official Full Name
    glycogen synthase kinase 3 betaprovided by VGNC
    Primary source
    VGNC:VGNC:41530
    See related
    Ensembl:ENSCAFG00845017754
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See GSK3B in Genome Data Viewer
    Location:
    chromosome: 33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 33 NC_051837.1 (23696164..23823688, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 33 NC_006615.4 (23488457..23689804, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 33 NC_049254.1 (24104403..24306119, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 33 NC_049293.1 (23500322..23702303, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 33 NC_049774.1 (23541326..23742436, complement)

    Chromosome 33 - NC_051837.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 91 Neighboring gene uncharacterized LOC106558176 Neighboring gene 60S ribosomal protein L27a-like Neighboring gene nuclear receptor subfamily 1 group I member 2 Neighboring gene small nucleolar RNA U3 Neighboring gene serine/arginine repetitive matrix protein 3-like Neighboring gene microRNA mir-6529

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β. Kirk JA, et al. J Clin Invest, 2014 Jan. PMID 24292707, Free PMC Article
    2. AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane. Zhang L, et al. J Biol Chem, 2011 May 13. PMID 21383016, Free PMC Article
    3. Helicobacter pylori suppresses glycogen synthase kinase 3beta to promote beta-catenin activity. Sokolova O, et al. J Biol Chem, 2008 Oct 24. PMID 18772141, Free PMC Article
    4. Oral administration of a GSK3 inhibitor increases brain insulin-like growth factor I levels. Bolós M, et al. J Biol Chem, 2010 Jun 4. PMID 20351102, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cardiac resynchronization therapy improves calcium responsiveness of myofilaments following heart failure through GSK-3beta reactivation.
      Title: Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β.
    2. AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3beta (GSK-3beta) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane
      Title: AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane.
    3. inhibiting GSK3 increases brain insulin-like growth factor I levels
      Title: Oral administration of a GSK3 inhibitor increases brain insulin-like growth factor I levels.
    4. glycogen synthase kinase 3beta activity exerts an important role in beta-catenin regulation and LEF/TCF transactivation in H. pylori-infected Madin-Darby canine kidney cells
      Title: Helicobacter pylori suppresses glycogen synthase kinase 3beta to promote beta-catenin activity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of beta-catenin destruction complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycogen synthase kinase-3 beta
    XP_005639593.1
    XP_038301303.1
    XP_038375261.1
    XP_038375262.1
    XP_038375263.1
    XP_038438882.1
    XP_038438884.1
    XP_038438885.1
    XP_038503270.1
    XP_038503271.1
    XP_038503272.1
    XP_535751.2
    XP_856611.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051837.1 Reference ROS_Cfam_1.0

      Range
      23696164..23823688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038445375.1 → XP_038301303.1  glycogen synthase kinase-3 beta isoform X1

      UniProtKB/TrEMBL
      A0A8I3P4F2
      Related
      ENSCAFP00845024619.1, ENSCAFT00845031438.1
      Conserved Domains (1) summary
      cd14137
      Location:17 → 279
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049293.1 Alternate UMICH_Zoey_3.1

      Range
      23500322..23702303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038519335.1 → XP_038375263.1  glycogen synthase kinase-3 beta isoform X4

      Conserved Domains (1) summary
      cd14137
      Location:51 → 356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    2. XM_038519333.1 → XP_038375261.1  glycogen synthase kinase-3 beta isoform X2

      Conserved Domains (1) summary
      cd14137
      Location:51 → 356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    3. XM_038519334.1 → XP_038375262.1  glycogen synthase kinase-3 beta isoform X3

      Conserved Domains (1) summary
      cd14137
      Location:51 → 343
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049774.1 Alternate UNSW_CanFamBas_1.0

      Range
      23541326..23742436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038647343.1 → XP_038503271.1  glycogen synthase kinase-3 beta isoform X6

      Conserved Domains (1) summary
      cd14137
      Location:51 → 343
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    2. XM_038647342.1 → XP_038503270.1  glycogen synthase kinase-3 beta isoform X5

      Conserved Domains (1) summary
      cd14137
      Location:51 → 356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    3. XM_038647344.1 → XP_038503272.1  glycogen synthase kinase-3 beta isoform X7

      Conserved Domains (1) summary
      cd14137
      Location:51 → 356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049254.1 Alternate UU_Cfam_GSD_1.0

      Range
      24104403..24306119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038582957.1 → XP_038438885.1  glycogen synthase kinase-3 beta isoform X10

      UniProtKB/TrEMBL
      A0A8P0ND25, A0A8P0NMG8
      Conserved Domains (1) summary
      cd14137
      Location:51 → 356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    2. XM_038582954.1 → XP_038438882.1  glycogen synthase kinase-3 beta isoform X8

      UniProtKB/TrEMBL
      A0A8C0MPF2, A0A8C0QWC0, A0A8P0ND25, A0A8P0PIC9
      Conserved Domains (1) summary
      cd14137
      Location:51 → 356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    3. XM_038582956.1 → XP_038438884.1  glycogen synthase kinase-3 beta isoform X9

      UniProtKB/TrEMBL
      A0A8C0JYA2, A0A8C0JZY6, A0A8C0T8A0
      Conserved Domains (1) summary
      cd14137
      Location:51 → 343
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006615.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      23488457..23689804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005639536.4 → XP_005639593.1  glycogen synthase kinase-3 beta isoform X13

      See identical proteins and their annotated locations for XP_005639593.1

      UniProtKB/TrEMBL
      A0A8P0ND25, A0A8P0NMG8
      Conserved Domains (1) summary
      cd14137
      Location:51 → 356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    2. XM_535751.7 → XP_535751.2  glycogen synthase kinase-3 beta isoform X11

      See identical proteins and their annotated locations for XP_535751.2

      UniProtKB/TrEMBL
      A0A8C0MPF2, A0A8C0QWC0, A0A8P0ND25, A0A8P0PIC9
      Conserved Domains (1) summary
      cd14137
      Location:51 → 356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    3. XM_851518.6 → XP_856611.1  glycogen synthase kinase-3 beta isoform X12

      See identical proteins and their annotated locations for XP_856611.1

      UniProtKB/TrEMBL
      A0A8C0JYA2, A0A8C0JZY6, A0A8C0T8A0
      Conserved Domains (1) summary
      cd14137
      Location:51 → 343
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
    Nucleotide Protein
    Heading Accession and Version

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