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    NKX2-8 NK2 homeobox 8 [ Canis lupus familiaris (dog) ]

    Gene ID: 609776, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NKX2-8provided by VGNC
    Official Full Name
    NK2 homeobox 8provided by VGNC
    Primary source
    VGNC:VGNC:43835
    See related
    Ensembl:ENSCAFG00845002657
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See NKX2-8 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (15261532..15263403, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (14949217..14951088, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (15316460..15318331, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (14959436..14961305, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (15026476..15028341, complement)

    Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119872840 Neighboring gene uncharacterized LOC111096999 Neighboring gene NK2 homeobox 1 Neighboring gene uncharacterized LOC119872844 Neighboring gene uncharacterized LOC119872843 Neighboring gene solute carrier family 25 member 21 Neighboring gene paired box 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans. Safra N, et al. PLoS Genet, 2013. PMID 23874236, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This is the first documentation of a potential role for NKX2-8 in the etiology of NTDs, made possible by investigating the molecular basis of naturally occurring mutations in dogs.
      Title: Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein Nkx-2.8
    Names
    NK2 transcription factor related, locus 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051812.1 Reference ROS_Cfam_1.0

      Range
      15261532..15263403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038672956.1 → XP_038528884.1  homeobox protein Nkx-2.8

      UniProtKB/TrEMBL
      A0A8C0TJ26, A0A8I3MFX0
      Related
      ENSCAFP00845003765.1, ENSCAFT00845004712.1
      Conserved Domains (1) summary
      pfam00046
      Location:87 → 141
      Homeobox; Homeobox domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049268.1 Alternate UMICH_Zoey_3.1

      Range
      14959436..14961305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038484461.1 → XP_038340389.1  homeobox protein Nkx-2.8

      Conserved Domains (1) summary
      pfam00046
      Location:87 → 141
      Homeobox; Homeobox domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

      Range
      15026476..15028341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038608157.1 → XP_038464085.1  homeobox protein Nkx-2.8

      Conserved Domains (1) summary
      pfam00046
      Location:87 → 141
      Homeobox; Homeobox domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

      Range
      15316460..15318331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038544032.1 → XP_038399960.1  homeobox protein Nkx-2.8

      UniProtKB/TrEMBL
      A0A8C0TJ26, A0A8I3MFX0
      Conserved Domains (1) summary
      pfam00046
      Location:87 → 141
      Homeobox; Homeobox domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      14949217..14951088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_847109.5 → XP_852202.2  homeobox protein Nkx-2.8

      UniProtKB/TrEMBL
      A0A8C0TJ26, A0A8I3MFX0
      Conserved Domains (1) summary
      pfam00046
      Location:87 → 141
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version

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