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    CAPN2 calpain 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 480118, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CAPN2provided by VGNC
    Official Full Name
    calpain 2provided by VGNC
    Primary source
    VGNC:VGNC:53334
    See related
    Ensembl:ENSCAFG00845013136
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (40166074..40204194, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (39815620..39853714, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (40285433..40323542, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (40007852..40045930, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (40016382..40054477, complement)

    Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119872560 Neighboring gene tumor protein p53 binding protein 2 Neighboring gene calpain 8 Neighboring gene uncharacterized LOC119872561 Neighboring gene uncharacterized LOC111096723

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calpain-2 catalytic subunit
    XP_038337464.1
    XP_038398823.1
    XP_038425753.1
    XP_038462941.1
    XP_038527666.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051811.1 Reference ROS_Cfam_1.0

      Range
      40166074..40204194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038671738.1 → XP_038527666.1  calpain-2 catalytic subunit

      UniProtKB/TrEMBL
      A0A8I3NDL3, A0A8I3NF92
      Related
      ENSCAFP00845018497.1, ENSCAFT00845023560.1
      Conserved Domains (3) summary
      cd00214
      Location:354 → 510
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16199
      Location:533 → 700
      EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
      pfam00648
      Location:46 → 342
      Peptidase_C2; Calpain family cysteine protease

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049267.1 Alternate UMICH_Zoey_3.1

      Range
      40007852..40045930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038481536.1 → XP_038337464.1  calpain-2 catalytic subunit

      Conserved Domains (3) summary
      cd00214
      Location:354 → 510
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16199
      Location:533 → 700
      EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
      pfam00648
      Location:46 → 342
      Peptidase_C2; Calpain family cysteine protease

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

      Range
      40016382..40054477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038607013.1 → XP_038462941.1  calpain-2 catalytic subunit

      Conserved Domains (3) summary
      cd00214
      Location:354 → 510
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16199
      Location:533 → 700
      EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
      pfam00648
      Location:46 → 342
      Peptidase_C2; Calpain family cysteine protease

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

      Range
      40285433..40323542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038542895.1 → XP_038398823.1  calpain-2 catalytic subunit

      UniProtKB/TrEMBL
      A0A8I3NDL3, A0A8I3NF92
      Conserved Domains (3) summary
      cd00214
      Location:354 → 510
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16199
      Location:533 → 700
      EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
      pfam00648
      Location:46 → 342
      Peptidase_C2; Calpain family cysteine protease

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      39815620..39853714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038569825.1 → XP_038425753.1  calpain-2 catalytic subunit

      UniProtKB/TrEMBL
      A0A8C0JS73, A0A8C0M6B8, A0A8C0SUD0, A0A8P0SIE2, A0A8P0SKP8
      Conserved Domains (3) summary
      cd00214
      Location:354 → 510
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16199
      Location:533 → 700
      EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
      pfam00648
      Location:46 → 342
      Peptidase_C2; Calpain family cysteine protease
    Nucleotide Protein
    Heading Accession and Version

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