SMO smoothened, frizzled class receptor [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: SMOprovided by VGNC
Official Full Name: smoothened, frizzled class receptorprovided by VGNC
Primary source: VGNC:VGNC:46565
See related: Ensembl:ENSCAFG00845020728
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	14	NC_051818.1 (7284734..7307875, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	14	NC_006596.4 (7206323..7229356, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	14	NC_049235.1 (7376821..7399952, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	14	NC_049274.1 (7489837..7512985, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	14	NC_049755.1 (7231685..7254904, complement)

Chromosome 14 - NC_051818.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables patched binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in commissural neuron axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cilium	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: smoothened homolog

Names: smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051818.1 Reference ROS_Cfam_1.0

Range

7284734..7307875 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038686174.1 → XP_038542102.1 smoothened homolog isoform X1

UniProtKB/TrEMBL

A0A8C0LA53, A0A8C0PCZ4, A0A8I3P5L7

Related

ENSCAFP00845028597.1, ENSCAFT00845036542.1

Conserved Domains (2) summary

cd07451
Location:65 → 195

CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein

cd15030
Location:219 → 549

7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
XM_038686175.1 → XP_038542103.1 smoothened homolog isoform X2

Conserved Domains (2) summary

cd15030
Location:90 → 420

7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

cl02447
Location:1 → 66

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

Alternate UMICH_Zoey_3.1

Genomic

NC_049274.1 Alternate UMICH_Zoey_3.1

Range

7489837..7512985 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038494259.1 → XP_038350187.1 smoothened homolog isoform X1

Conserved Domains (2) summary

cd07451
Location:65 → 195

CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein

cd15030
Location:219 → 549

7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
XM_038494260.1 → XP_038350188.1 smoothened homolog isoform X2

Conserved Domains (2) summary

cd15030
Location:90 → 420

7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

cl02447
Location:1 → 66

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049755.1 Alternate UNSW_CanFamBas_1.0

Range

7231685..7254904 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038620488.1 → XP_038476416.1 smoothened homolog isoform X1

Conserved Domains (2) summary

cd07451
Location:65 → 195

CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein

cd15030
Location:219 → 549

7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
XM_038620489.1 → XP_038476417.1 smoothened homolog isoform X2

Conserved Domains (2) summary

cd15030
Location:90 → 420

7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

cl02447
Location:1 → 66

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049235.1 Alternate UU_Cfam_GSD_1.0

Range

7376821..7399952 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038556554.1 → XP_038412482.1 smoothened homolog isoform X1

UniProtKB/TrEMBL

A0A8C0LA53, A0A8C0PCZ4, A0A8I3P5L7

Conserved Domains (2) summary

cd07451
Location:65 → 195

CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein

cd15030
Location:219 → 549

7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
XM_038556555.1 → XP_038412483.1 smoothened homolog isoform X2

Conserved Domains (2) summary

cd15030
Location:90 → 420

7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

cl02447
Location:1 → 66

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006596.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

7206323..7229356 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038443356.1 → XP_038299284.1 smoothened homolog isoform X1

UniProtKB/TrEMBL

A0A8C0LA53, A0A8C0PCZ4, A0A8I3P5L7

Conserved Domains (2) summary

cd07451
Location:65 → 195

CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein

cd15030
Location:219 → 549

7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
XM_038443362.1 → XP_038299290.1 smoothened homolog isoform X2

Conserved Domains (2) summary

cd15030
Location:90 → 420

7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

cl02447
Location:1 → 66

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain