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    NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 485139, updated on 22-Jan-2024

    Summary

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    Official Symbol
    NAALAD2provided by VGNC
    Official Full Name
    N-acetylated alpha-linked acidic dipeptidase 2provided by VGNC
    Primary source
    VGNC:VGNC:52270
    See related
    Ensembl:ENSCAFG00845024559
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
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    Genomic context

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    See NAALAD2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (10339550..10404777, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (10054329..10119513, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (10243380..10308589, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (10138437..10197311, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (10193157..10258556, complement)

    Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111091492 Neighboring gene uncharacterized LOC119864952 Neighboring gene cysteine and histidine rich domain containing 1 Neighboring gene uncharacterized LOC119864954 Neighboring gene tripartite motif-containing protein 43-like Neighboring gene tripartite motif-containing protein 77-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetylated-alpha-linked acidic dipeptidase 2; LOW QUALITY PROTEIN: N-acetylated-alpha-linked acidic dipeptidase 2
    XP_005633427.2
    XP_005633428.2
    XP_005633429.2
    XP_005633432.1
    XP_022263243.2
    XP_022263246.1
    XP_022263247.1
    XP_038285722.1
    XP_038285723.1
    XP_038285724.1
    XP_038285725.1
    XP_038285726.1
    XP_038285727.1
    XP_038285728.1
    XP_038285729.1
    XP_038285730.1
    XP_038312331.1
    XP_038361131.1
    XP_038424265.1
    XP_038424266.1
    XP_038424267.1
    XP_038424268.1
    XP_038424269.1
    XP_038424270.1
    XP_038424271.1
    XP_038424272.1
    XP_038424273.1
    XP_038488409.1
    XP_038488410.1
    XP_038488411.1
    XP_038488412.1
    XP_038488413.1
    XP_038488414.1
    XP_038488415.1
    XP_038488416.1
    XP_038488417.1
    XP_542257.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051825.1 Reference ROS_Cfam_1.0

      Range
      10339550..10404777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038429796.1 → XP_038285724.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I3PHW8
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:97 → 142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. XM_038429795.1 → XP_038285723.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I3PHW8
      Related
      ENSCAFP00845033968.1, ENSCAFT00845043348.1
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:97 → 142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    3. XM_038429797.1 → XP_038285725.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8P0PDH7
      Conserved Domains (3) summary
      cd02121
      Location:165 → 340
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:348 → 589
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:621 → 740
      TFR_dimer; Transferrin receptor-like dimerization domain

    4. XM_038429794.1 → XP_038285722.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I3PHW8
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:97 → 142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    5. XM_038429798.1 → XP_038285726.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I3PR91
      Related
      ENSCAFP00845034125.1, ENSCAFT00845043561.1
      Conserved Domains (4) summary
      cd02121
      Location:56 → 282
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:290 → 531
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:563 → 682
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:5 → 50
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    6. XM_038429799.1 → XP_038285727.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X4

      Conserved Domains (2) summary
      cd08022
      Location:42 → 336
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:368 → 487
      TFR_dimer; Transferrin receptor-like dimerization domain

    7. XM_038429802.1 → XP_038285730.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X6

      Conserved Domains (2) summary
      cd08022
      Location:46 → 287
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:319 → 438
      TFR_dimer; Transferrin receptor-like dimerization domain

    8. XM_038429800.1 → XP_038285728.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X5

      Conserved Domains (2) summary
      cd08022
      Location:37 → 331
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:363 → 482
      TFR_dimer; Transferrin receptor-like dimerization domain

    9. XM_038429801.1 → XP_038285729.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X6

      Conserved Domains (2) summary
      cd08022
      Location:46 → 287
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:319 → 438
      TFR_dimer; Transferrin receptor-like dimerization domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049281.1 Alternate UMICH_Zoey_3.1

      Range
      10138437..10197311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038505203.1 → XP_038361131.1  LOW QUALITY PROTEIN: N-acetylated-alpha-linked acidic dipeptidase 2 isoform X7

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

      Range
      10193157..10258556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038632483.1 → XP_038488411.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

    2. XM_038632482.1 → XP_038488410.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

    3. XM_038632484.1 → XP_038488412.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X2

    4. XM_038632481.1 → XP_038488409.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

    5. XM_038632485.1 → XP_038488413.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X3

    6. XM_038632486.1 → XP_038488414.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X4

    7. XM_038632489.1 → XP_038488417.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X6

      Conserved Domains (2) summary
      cd08022
      Location:46 → 287
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:319 → 438
      TFR_dimer; Transferrin receptor-like dimerization domain

    8. XM_038632487.1 → XP_038488415.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X5

    9. XM_038632488.1 → XP_038488416.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X6

      Conserved Domains (2) summary
      cd08022
      Location:46 → 287
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:319 → 438
      TFR_dimer; Transferrin receptor-like dimerization domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

      Range
      10243380..10308589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038568339.1 → XP_038424267.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8P0NY96, A0A8P0PPA6
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:97 → 142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. XM_038568338.1 → XP_038424266.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8P0NY96, A0A8P0PPA6
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:97 → 142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    3. XM_038568340.1 → XP_038424268.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8P0PDH7
      Conserved Domains (3) summary
      cd02121
      Location:165 → 340
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:348 → 589
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:621 → 740
      TFR_dimer; Transferrin receptor-like dimerization domain

    4. XM_038568337.1 → XP_038424265.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8P0NY96, A0A8P0PPA6
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:97 → 142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    5. XM_038568341.1 → XP_038424269.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8P0P638
      Conserved Domains (4) summary
      cd02121
      Location:56 → 282
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:290 → 531
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:563 → 682
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:5 → 50
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    6. XM_038568342.1 → XP_038424270.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X4

      Conserved Domains (2) summary
      cd08022
      Location:42 → 336
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:368 → 487
      TFR_dimer; Transferrin receptor-like dimerization domain

    7. XM_038568345.1 → XP_038424273.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X6

      Conserved Domains (2) summary
      cd08022
      Location:46 → 287
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:319 → 438
      TFR_dimer; Transferrin receptor-like dimerization domain

    8. XM_038568343.1 → XP_038424271.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X5

      Conserved Domains (2) summary
      cd08022
      Location:37 → 331
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:363 → 482
      TFR_dimer; Transferrin receptor-like dimerization domain

    9. XM_038568344.1 → XP_038424272.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X6

      Conserved Domains (2) summary
      cd08022
      Location:46 → 287
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:319 → 438
      TFR_dimer; Transferrin receptor-like dimerization domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      10054329..10119513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_542257.6 → XP_542257.4  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8P0NY96, A0A8P0PPA6
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:97 → 142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. XM_005633370.4 → XP_005633427.2  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8P0NY96, A0A8P0PPA6
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:97 → 142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    3. XM_022407535.2 → XP_022263243.2  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8P0PDH7
      Conserved Domains (3) summary
      cd02121
      Location:165 → 340
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:348 → 589
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:621 → 740
      TFR_dimer; Transferrin receptor-like dimerization domain

    4. XM_005633371.4 → XP_005633428.2  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8P0NY96, A0A8P0PPA6
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:97 → 142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    5. XM_005633372.3 → XP_005633429.2  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8P0P638
      Conserved Domains (4) summary
      cd02121
      Location:56 → 282
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:290 → 531
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:563 → 682
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:5 → 50
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    6. XM_022407538.2 → XP_022263246.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X4

      Conserved Domains (2) summary
      cd08022
      Location:42 → 336
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:368 → 487
      TFR_dimer; Transferrin receptor-like dimerization domain

    7. XM_005633375.4 → XP_005633432.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X6

      See identical proteins and their annotated locations for XP_005633432.1

      Conserved Domains (2) summary
      cd08022
      Location:46 → 287
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:319 → 438
      TFR_dimer; Transferrin receptor-like dimerization domain

    8. XM_022407539.2 → XP_022263247.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X5

      Conserved Domains (2) summary
      cd08022
      Location:37 → 331
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:363 → 482
      TFR_dimer; Transferrin receptor-like dimerization domain

    9. XM_038456403.1 → XP_038312331.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X6

      Conserved Domains (2) summary
      cd08022
      Location:46 → 287
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:319 → 438
      TFR_dimer; Transferrin receptor-like dimerization domain
    Nucleotide Protein
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