FOLH1B folate hydrolase 1B [Canis lupus familiaris (dog)] - Gene

Summary

Gene symbol: FOLH1B
Gene description: folate hydrolase 1B
See related: Ensembl:ENSCAFG00845025397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: PSMA; FOLH1
Orthologs: human all
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Genomic context

Location:: chromosome: 21

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	21	NC_051825.1 (10582575..10647371, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	21	NC_006603.4 (10252624..10317104, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	21	NC_049242.1 (10486267..10550766, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	21	NC_049281.1 (10371141..10435721, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	21	NC_049762.1 (10429798..10494435, complement)

Chromosome 21 - NC_051825.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

characterized the differential quantitative expressions of PSMA between canine hemangiosarcoma (cHSA) and non-malignant tissues, and determined the potential diagnostic utility of PCR-generated PSMA amplicons as a surrogate of rare cHSA cells dwelling within peritoneal and pericardial cavities
Title: Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions.
Canine PSMA reveals similar characteristics to human PSMA rendering this protein useful as a translational model for investigations of prostate cancer as well as a suitable antigen for targeted therapy studies in dogs.
Title: Cloning and characterization of canine prostate-specific membrane antigen.
Immunohistochemically, 50% or more of the canine prostate cancer cases showed expression of PSA, PSMA, UPIII, CK7, CK5, CK14, and CK18.
Title: Histopathological and immunohistochemical characterization of canine prostate cancer.
acquisition of folding determinants in the Golgi is an essential prerequisite for protein trafficking and sorting of PSMA
Title: Apical transport and folding of prostate-specific membrane antigen occurs independent of glycan processing.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: Putative N-acetylated-alpha-linked acidic dipeptidase

Names: folate hydrolase (prostate-specific membrane antigen) 1; folate hydrolase 1; prostate-specific membrane antigen

NP_001258707.1

EC 3.4.17.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271778.1 → NP_001258707.1 Putative N-acetylated-alpha-linked acidic dipeptidase

Status: VALIDATED

Source sequence(s)

HE820284

UniProtKB/TrEMBL

A0A8C0KTI3, A0A8C0N3B8, A0A8I3PUM6

Related

ENSCAFP00845035166.1, ENSCAFT00845044871.1

Conserved Domains (4) summary

cd08022
Location:355 → 596

M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen

cd02121
Location:121 → 347

PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...

pfam04253
Location:633 → 744

TFR_dimer; Transferrin receptor-like dimerisation domain

cl14876
Location:69 → 115

Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42