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    ZBTB2 zinc finger and BTB domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 57621, updated on 7-Apr-2024

    Summary

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    Official Symbol
    ZBTB2provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:20868
    See related
    Ensembl:ENSG00000181472 MIM:616595; AllianceGenome:HGNC:20868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF437
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 17.1), lymph node (RPKM 6.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZBTB2 in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (151364115..151391559, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (152564691..152592145, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (151685250..151712694, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 12 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:151645454-151645654 Neighboring gene RN7SK pseudogene 268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:151662497-151663014 Neighboring gene uncharacterized LOC124901550 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:151675923-151676424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25281 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17687 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:151712707-151713579 Neighboring gene uncharacterized LOC124901433 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 15 Neighboring gene required for meiotic nuclear division 1 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness. Koyasu S, et al. EMBO Rep, 2023 Jan 9. PMID 36341521, Free PMC Article
    2. DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation. Lafaye C, et al. Biochem Biophys Res Commun, 2014 Mar 28. PMID 24607898
    3. MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma. Yang Y, et al. J Cell Biochem, 2019 Nov. PMID 31243806
    4. OIP5-AS1 promotes the progression of gastric cancer cells via the miR-153-3p/ZBTB2 axis. Zhi XH, et al. Eur Rev Med Pharmacol Sci, 2020 Mar. PMID 32196594
    5. MiR-4282 inhibits tumor progression through down-regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma. Zhang Y, et al. J Cell Physiol, 2020 Nov. PMID 31970774

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZBTB2 is Recruited to a Specific Subset of HIF-1 Target Loci to Facilitate Full Gene Expression Under Hypoxia.
      Title: ZBTB2 is Recruited to a Specific Subset of HIF-1 Target Loci to Facilitate Full Gene Expression Under Hypoxia.
    2. ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness.
      Title: ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness.
    3. ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.
      Title: ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.
    4. OIP5-AS1 promotes the progression of gastric cancer cells via the miR-153-3p/ZBTB2 axis.
      Title: OIP5-AS1 promotes the progression of gastric cancer cells via the miR-153-3p/ZBTB2 axis.
    5. MiR-4282 inhibits tumor progression through down-regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma.
      Title: MiR-4282 inhibits tumor progression through down-regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma.
    6. MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma.
      Title: MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma.
    7. long noncoding RNA CALML3-AS1 promotes tumorigenesis of bladder cancer via regulating ZBTB2 by suppression of microRNA-4316
      Title: LncRNA CALML3-AS1 promotes tumorigenesis of bladder cancer via regulating ZBTB2 by suppression of microRNA-4316.
    8. ZBTB2 may increase cell proliferation by reprogramming glucose metabolic pathways to favor glycolysis by upregulating PDK4 expression via repression of RelA/p65 expression
      Title: ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65.
    9. ZBTB2 being considered as a multifunctional cell proliferation activator, notably through p21 repression, this work points out new epigenetic processes potentially involved in carcinogenesis.
      Title: DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation.
    10. ZBTB2 is a potential proto-oncogenic master control gene of the p53 pathway and, in particular, is a potent transcription repressor of the cell cycle arrest gene p21 by inhibiting p53 and Sp1
      Title: ZBTB2, a novel master regulator of the p53 pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger and BTB domain containing 2 (ZBTB2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020861.3 → NP_065912.1  zinc finger and BTB domain-containing protein 2

      See identical proteins and their annotated locations for NP_065912.1

      Status: VALIDATED

      Source sequence(s)
      AK291942, BC020172
      Consensus CDS
      CCDS5231.1
      UniProtKB/Swiss-Prot
      A8K7C7, Q5SZ81, Q8N680, Q9P245
      UniProtKB/TrEMBL
      Q658W5
      Related
      ENSP00000323183.4, ENST00000325144.5
      Conserved Domains (4) summary
      sd00017
      Location:365 → 385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:363 → 385
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 84
      BTB; BTB/POZ domain
      pfam13465
      Location:377 → 399
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      151364115..151391559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005267076.4 → XP_005267133.1  zinc finger and BTB domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005267133.1

      UniProtKB/Swiss-Prot
      A8K7C7, Q5SZ81, Q8N680, Q9P245
      UniProtKB/TrEMBL
      Q658W5
      Conserved Domains (4) summary
      sd00017
      Location:365 → 385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:363 → 385
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 84
      BTB; BTB/POZ domain
      pfam13465
      Location:377 → 399
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011536004.3 → XP_011534306.1  zinc finger and BTB domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011534306.1

      UniProtKB/Swiss-Prot
      A8K7C7, Q5SZ81, Q8N680, Q9P245
      UniProtKB/TrEMBL
      Q658W5
      Conserved Domains (4) summary
      sd00017
      Location:365 → 385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:363 → 385
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 84
      BTB; BTB/POZ domain
      pfam13465
      Location:377 → 399
      zf-H2C2_2; Zinc-finger double domain

    3. XM_047419188.1 → XP_047275144.1  zinc finger and BTB domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K7C7, Q5SZ81, Q8N680, Q9P245

    4. XM_047419189.1 → XP_047275145.1  zinc finger and BTB domain-containing protein 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      152564691..152592145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356106.1 → XP_054212081.1  zinc finger and BTB domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K7C7, Q5SZ81, Q8N680, Q9P245

    2. XM_054356107.1 → XP_054212082.1  zinc finger and BTB domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K7C7, Q5SZ81, Q8N680, Q9P245

    3. XM_054356108.1 → XP_054212083.1  zinc finger and BTB domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K7C7, Q5SZ81, Q8N680, Q9P245

    4. XM_054356109.1 → XP_054212084.1  zinc finger and BTB domain-containing protein 2 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N680.1 GenPept UniProtKB/Swiss-Prot:Q8N680

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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