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    Ciao1 cytosolic iron-sulfur assembly component 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29231, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ciao1provided by RGD
    Official Full Name
    cytosolic iron-sulfur assembly component 1provided by RGD
    Primary source
    RGD:1307285
    See related
    Ensembl:ENSRNOG00000012638 AllianceGenome:RGD:1307285
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr39
    Summary
    Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytoplasm. Predicted to be part of CIA complex and MMXD complex. Orthologous to human CIAO1 (cytosolic iron-sulfur assembly component 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 162.7), Muscle (RPKM 159.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ciao1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (134913639..134919244, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (114458671..114465928, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (119671778..119677324, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ITPRIP like 1 Neighboring gene small nuclear ribonucleoprotein U5 subunit 200 Neighboring gene transmembrane protein 127 Neighboring gene StAR-related lipid transfer domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis. Srinivasan V, et al. Structure, 2007 Oct. PMID 17937914
    2. Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. Paul VD, et al. Biochim Biophys Acta, 2015 Jun. PMID 25583461
    3. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. Ito S, et al. Mol Cell, 2010 Aug 27. PMID 20797633
    4. IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway. Seki M, et al. J Biol Chem, 2013 Jun 7. PMID 23585563, Free PMC Article
    5. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Gari K, et al. Science, 2012 Jul 13. PMID 22678361

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95143

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of CIA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CIA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CIA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CIA complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of MMXD complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MMXD complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MMXD complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    probable cytosolic iron-sulfur protein assembly protein CIAO1
    Names
    WD repeat domain 39
    WD repeat-containing protein 39
    WD40 protein Ciao1
    cytosolic iron-sulfur protein assembly 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008766.1 → NP_001008766.1  probable cytosolic iron-sulfur protein assembly protein CIAO1

      See identical proteins and their annotated locations for NP_001008766.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088474
      UniProtKB/Swiss-Prot
      Q5M7T1
      UniProtKB/TrEMBL
      A0A8L2UJ40, A6HQ07
      Related
      ENSRNOP00000017603.4, ENSRNOT00000017603.6
      Conserved Domains (3) summary
      COG2319
      Location:22 → 335
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:17 → 332
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:19 → 58
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      134913639..134919244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104428.2 → XP_038960356.1  probable cytosolic iron-sulfur protein assembly protein CIAO1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7Q2
      Related
      ENSRNOP00000089224.1
      Conserved Domains (2) summary
      cd00200
      Location:17 → 221
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:19 → 58
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_010064575.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M7T1.1 GenPept UniProtKB/Swiss-Prot:Q5M7T1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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