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    Rasgrp3 RAS, guanyl releasing protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 240168, updated on 14-May-2024

    Summary

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    Official Symbol
    Rasgrp3provided by MGI
    Official Full Name
    RAS, guanyl releasing protein 3provided by MGI
    Primary source
    MGI:MGI:3028579
    See related
    Ensembl:ENSMUSG00000071042 AllianceGenome:MGI:3028579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm327
    Summary
    Enables guanyl-nucleotide exchange factor activity; kinase binding activity; and small GTPase binding activity. Acts upstream of or within Ras protein signal transduction and regulation of GTPase activity. Located in perinuclear region of cytoplasm. Part of guanyl-nucleotide exchange factor complex. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RASGRP3 (RAS guanyl releasing protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 6.2), heart adult (RPKM 3.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E2; 17 46.55 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (75742849..75836049)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (75435870..75529054)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31818 Neighboring gene STARR-seq mESC enhancer starr_43233 Neighboring gene latent transforming growth factor beta binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_43235 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43238 Neighboring gene STARR-positive B cell enhancer ABC_E9966 Neighboring gene STARR-seq mESC enhancer starr_43240 Neighboring gene STARR-positive B cell enhancer ABC_E10971 Neighboring gene STARR-seq mESC enhancer starr_43241 Neighboring gene STARR-positive B cell enhancer ABC_E4226 Neighboring gene STARR-seq mESC enhancer starr_43242 Neighboring gene STARR-positive B cell enhancer ABC_E8697 Neighboring gene STARR-positive B cell enhancer ABC_E9443 Neighboring gene STARR-positive B cell enhancer ABC_E5628 Neighboring gene STARR-positive B cell enhancer ABC_E7558 Neighboring gene STARR-positive B cell enhancer ABC_E143 Neighboring gene predicted gene, 53979 Neighboring gene family with sequence similarity 98, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase. Tang S, et al. Nat Commun, 2014 Aug 14. PMID 25118589, Free PMC Article
    2. The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration. Randhawa PK, et al. Circ Res, 2011 May 13. PMID 21474816, Free PMC Article
    3. RasGRP1 and RasGRP3 Are Required for Efficient Generation of Early Thymic Progenitors. Golec DP, et al. J Immunol, 2016 Sep 1. PMID 27465532
    4. RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. Coughlin JJ, et al. J Immunol, 2005 Dec 1. PMID 16301621
    5. RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4. Golec DP, et al. PLoS One, 2013. PMID 23308188, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RasGRP3 is specifically required for GNAQ/GNA11-driven Ras activation and tumorigenesis.
      Title: GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.
    2. RasGRP1/3-deficient progenitors show impaired migration toward the CCR9 ligand, CCL25, suggesting that RasGRP1 and RasGRP3 may regulate progenitor entry into the thymus through a CCR9-dependent mechanism.
      Title: RasGRP1 and RasGRP3 Are Required for Efficient Generation of Early Thymic Progenitors.
    3. RasGRP3 limits inflammatory response by activating Rap1 on low-intensity pathogen infection, setting a threshold for preventing excessive inflammatory response.
      Title: RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase.
    4. RasGRP1, but not RasGRP3, is required for thymocyte positive selection and invariant natural killer T cell selection.
      Title: RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4.
    5. Expressed in developing blood vessels, Rasgrp3 contributes to the incidence of cardiovascular defects found in embryos from diabetic mothers.
      Title: The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC74365, MGC79207

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras guanyl-releasing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166493.2 → NP_001159965.1  ras guanyl-releasing protein 3

      See identical proteins and their annotated locations for NP_001159965.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC118018, CT010501
      Consensus CDS
      CCDS37695.1
      UniProtKB/TrEMBL
      Q69ZX7, Q6NZH9
      Related
      ENSMUSP00000129393.2, ENSMUST00000164192.9
      Conserved Domains (4) summary
      cd06224
      Location:11 → 126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148 → 384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:495 → 544
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13499
      Location:428 → 478
      EF-hand_7; EF-hand domain pair

    2. NM_001360103.1 → NP_001347032.1  ras guanyl-releasing protein 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      CT010501
      Consensus CDS
      CCDS37695.1
      UniProtKB/TrEMBL
      Q69ZX7, Q6NZH9
      Conserved Domains (4) summary
      cd06224
      Location:11 → 126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148 → 384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:495 → 544
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13499
      Location:428 → 478
      EF-hand_7; EF-hand domain pair

    3. NM_001411230.1 → NP_001398159.1  ras guanyl-releasing protein 3

      Status: VALIDATED

      Source sequence(s)
      AC118018, CT010501
      UniProtKB/TrEMBL
      Q6NZH9

    4. NM_207246.4 → NP_997129.1  ras guanyl-releasing protein 3

      See identical proteins and their annotated locations for NP_997129.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC066069, BY123705, CJ131259
      Consensus CDS
      CCDS37695.1
      UniProtKB/TrEMBL
      Q69ZX7, Q6NZH9
      Related
      ENSMUSP00000092828.5, ENSMUST00000095204.6
      Conserved Domains (4) summary
      cd06224
      Location:11 → 126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148 → 384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:495 → 544
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13499
      Location:428 → 478
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      75742849..75836049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524273.4 → XP_006524336.1  ras guanyl-releasing protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006524336.1

      UniProtKB/TrEMBL
      Q69ZX7
      Conserved Domains (4) summary
      cd06224
      Location:11 → 126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148 → 384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:494 → 543
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13499
      Location:427 → 477
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein Strain
    Heading Accession and Version

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