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    MZF1 myeloid zinc finger 1 [ Homo sapiens (human) ]

    Gene ID: 7593, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MZF1provided by HGNC
    Official Full Name
    myeloid zinc finger 1provided by HGNC
    Primary source
    HGNC:HGNC:13108
    See related
    Ensembl:ENSG00000099326 MIM:194550; AllianceGenome:HGNC:13108
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen (RPKM 4.6), prostate (RPKM 4.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19q13.43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58561932..58573573, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61659609..61672553, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59073299..59084940, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59067095-59067778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15211 Neighboring gene ubiquitin conjugating enzyme E2 M Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59070738-59071334 Neighboring gene MZF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11096 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59083407-59084268 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59084269-59085128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15214 Neighboring gene CENPB DNA-binding domains containing 2, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59093108-59093611 Neighboring gene uncharacterized LOC107987272

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MZF1 mediates oncogene-induced senescence by promoting the transcription of p16(INK4A). Wu D, et al. Oncogene, 2022 Jan. PMID 34773072, Free PMC Article
    2. Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer. Eguchi T, et al. J Cell Biochem, 2015 Oct. PMID 25903835, Free PMC Article
    3. Expression of myeloid zinc finger 1 and the correlation to clinical aspects of oral squamous cell carcinoma. Ko CP, et al. Tumour Biol, 2015 Sep. PMID 25877752
    4. Haplotype of single nucleotide polymorphisms in exon 6 of the MZF-1 gene and Alzheimer's disease. Porcellini E, et al. J Alzheimers Dis, 2013. PMID 23241556
    5. Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein. Peterson MJ, et al. Gene, 2000 Aug 22. PMID 10974541

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant Progression of Hepatocellular Carcinoma.
      Title: LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant Progression of Hepatocellular Carcinoma.
    2. MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription.
      Title: MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription.
    3. MZF1 mediates oncogene-induced senescence by promoting the transcription of p16(INK4A).
      Title: MZF1 mediates oncogene-induced senescence by promoting the transcription of p16(INK4A).
    4. Cigarette smoke modulates binding of the transcription factor MZF1 to the VEGF promoter and regulates VEGF expression in dependence of genetic variation SNP 405.
      Title: Cigarette smoke modulates binding of the transcription factor MZF1 to the VEGF promoter and regulates VEGF expression in dependence of genetic variation SNP 405.
    5. Metallothionein 2A (MT2A)/myeloid zinc-finger 1 (MZF1) may serve as a prognostic marker and a therapeutic target for human gastric cancer.
      Title: Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human Gastric Carcinogenesis by Interacting with Metallothionein 2A.
    6. Exogenous expression of the acidic domain of MZF1 repressed the binding of endogenous MZF1 to IGF1R promoter via blocking the interaction with ETS-like gene 1 (ELK1). This blockage not only caused MZF1 protein degradation, but also restrained ELK1 nuclear localization in high-level MZF1-expressing TNBC cells. MZF1, but not ELK1, was necessary for the retention of mesenchymal phenotype by repressing IGF1R promoter activity
      Title: Myeloid Zinc Finger 1 (MZF1) Maintains the Mesenchymal Phenotype by Down-regulating IGF1R/p38 MAPK/ERα Signaling Pathway in High-level MZF1-expressing TNBC cells.
    7. Mechanistically, FTO enhanced MZF1 expression by reducing m(6)A levels and mRNA stability in MZF1 mRNA transcript, leading to oncogenic functions.
      Title: m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression.
    8. MZF1 gene expression was not significantly correlated with PYROXD2 protein expression in the samples of resected tumor tissues, which revealed that the PYROXD2 promoter transcription activity was determined by the aggregated effect of numerous transcription factors. This finding may be helpful in understanding the underlying mechanism which regulates the PYROXD2 expression.
      Title: Myeloid zinc finger 1 protein is a key transcription stimulating factor of PYROXD2 promoter.
    9. PAX2 is involved in the carcinogenesis of endometrial cancer by stimulating cell growth and promoting cell motility; the overexpression of PAX2 in endometrial cancer is regulated by promoter hypermethylation and the transcription factor MZF1
      Title: DNA methylation promotes paired box 2 expression via myeloid zinc finger 1 in endometrial cancer.
    10. miR-337-3p directly binds to the MMP-14 promoter to repress MZF1-facilitatd MMP-14 expression, thus suppressing the progression of gastric cancer
      Title: miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    myeloid zinc finger 1
    Names
    zinc finger and SCAN domain-containing protein 6
    zinc finger protein 42 (myeloid-specific retinoic acid-responsive)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267033.2 → NP_001253962.1  myeloid zinc finger 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF055078, BC007777, BC053316
      Consensus CDS
      CCDS59427.1
      UniProtKB/TrEMBL
      M0R1U5
      Related
      ENSP00000469378.1, ENST00000594234.5
      Conserved Domains (2) summary
      smart00431
      Location:40 → 152
      SCAN; leucine rich region
      pfam02023
      Location:40 → 128
      SCAN; SCAN domain

    2. NM_003422.3 → NP_003413.2  myeloid zinc finger 1 isoform 1

      See identical proteins and their annotated locations for NP_003413.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AF055077, BC007777
      Consensus CDS
      CCDS12988.1
      UniProtKB/Swiss-Prot
      M0QXU0, P28698, Q7Z729, Q96I71, Q9NRY0, Q9UBW2
      Related
      ENSP00000469493.1, ENST00000599369.5
      Conserved Domains (4) summary
      smart00431
      Location:40 → 152
      SCAN; leucine rich region
      COG5048
      Location:358 → 716
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:543 → 563
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_198055.2 → NP_932172.1  myeloid zinc finger 1 isoform 1

      See identical proteins and their annotated locations for NP_932172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AF055078, BC007777
      Consensus CDS
      CCDS12988.1
      UniProtKB/Swiss-Prot
      M0QXU0, P28698, Q7Z729, Q96I71, Q9NRY0, Q9UBW2
      Related
      ENSP00000215057.1, ENST00000215057.7
      Conserved Domains (4) summary
      smart00431
      Location:40 → 152
      SCAN; leucine rich region
      COG5048
      Location:358 → 716
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:543 → 563
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58561932..58573573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439312.1 → XP_047295268.1  myeloid zinc finger 1 isoform X1

    2. XM_011527264.4 → XP_011525566.1  myeloid zinc finger 1 isoform X2

      Conserved Domains (7) summary
      smart00431
      Location:70 → 182
      SCAN; leucine rich region
      COG5048
      Location:388 → 746
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:573 → 593
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:472 → 492
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:388 → 408
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:70 → 158
      SCAN; SCAN domain
      pfam13465
      Location:697 → 722
      zf-H2C2_2; Zinc-finger double domain

    3. XM_047439313.1 → XP_047295269.1  myeloid zinc finger 1 isoform X1

    4. XM_005259204.4 → XP_005259261.1  myeloid zinc finger 1 isoform X1

      See identical proteins and their annotated locations for XP_005259261.1

      Conserved Domains (4) summary
      smart00431
      Location:81 → 193
      SCAN; leucine rich region
      COG5048
      Location:399 → 757
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:584 → 604
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:483 → 503
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_017027206.2 → XP_016882695.1  myeloid zinc finger 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61659609..61672553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321951.1 → XP_054177926.1  myeloid zinc finger 1 isoform X2

    2. XM_054321948.1 → XP_054177923.1  myeloid zinc finger 1 isoform X1

    3. XM_054321950.1 → XP_054177925.1  myeloid zinc finger 1 isoform X1

    4. XM_054321949.1 → XP_054177924.1  myeloid zinc finger 1 isoform X1

    5. XM_054321952.1 → XP_054177927.1  myeloid zinc finger 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28698.3 GenPept UniProtKB/Swiss-Prot:P28698

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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