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Rtn4 reticulon 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83765, updated on 2-May-2024

Summary

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Official Symbol: Rtn4provided by RGD
Official Full Name: reticulon 4provided by RGD
Primary source: RGD:620989
See related: Ensembl:ENSRNOG00000004621 AllianceGenome:RGD:620989
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nogo; Vp20; rat N; NI-250; Nogo-A; rat NogoA
Summary: Predicted to enable cadherin binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of neuron projection regeneration; nervous system development; and positive regulation of dopamine secretion. Located in several cellular components, including endoplasmic reticulum; myelin sheath; and neuronal cell body. Is integral component of endoplasmic reticulum membrane. Part of protein-containing complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Biomarker of visual epilepsy. Orthologous to human RTN4 (reticulon 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 663.4), Brain (RPKM 396.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Rtn4 in Genome Data Viewer

Location:: 14q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (107651001..107698610)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (103450074..103497687)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (114126931..114174459)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel Function of Nogo-A as Negative Regulator of Endothelial Progenitor Cell Angiogenic Activity: Impact in Oxygen-Induced Retinopathy.
Title: Novel Function of Nogo-A as Negative Regulator of Endothelial Progenitor Cell Angiogenic Activity: Impact in Oxygen-Induced Retinopathy.
RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary neural repair through enhancing vascular autophagy in the thalamus after cerebral cortical infarction.
Title: RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary neural repair through enhancing vascular autophagy in the thalamus after cerebral cortical infarction.
The Effect of Mild Hypothermia on Nogo-A and Neurological Function in the Brain after Cardiopulmonary Resuscitation in Rats.
Title: The Effect of Mild Hypothermia on Nogo-A and Neurological Function in the Brain after Cardiopulmonary Resuscitation in Rats.
Nogo-A-Delta20/EphA4 interaction antagonizes apoptosis of neural stem cells by integrating p38 and JNK MAPK signaling.
Title: Nogo-A-Δ20/EphA4 interaction antagonizes apoptosis of neural stem cells by integrating p38 and JNK MAPK signaling.
Nogo-A Induced Polymerization of Microtubule Is Involved in the Inflammatory Heat Hyperalgesia in Rat Dorsal Root Ganglion Neurons.
Title: Nogo-A Induced Polymerization of Microtubule Is Involved in the Inflammatory Heat Hyperalgesia in Rat Dorsal Root Ganglion Neurons.
Nogo66 promotes betaamyloid protein secretion via NgR/ROCKdependent BACE1 activation.
Title: Nogo‑66 promotes β‑amyloid protein secretion via NgR/ROCK‑dependent BACE1 activation.
Expression of Nogo-A in dorsal root ganglion in rats with cauda equina injury.
Title: Expression of Nogo-A in dorsal root ganglion in rats with cauda equina injury.
Cyclic-AMP induces Nogo-A receptor NgR1 internalization and inhibits Nogo-A-mediated collapse of growth cone.
Title: Cyclic-AMP induces Nogo-A receptor NgR1 internalization and inhibits Nogo-A-mediated collapse of growth cone.
Nogo-A maintains TRPV-1 function in the rat dorsal root ganglion neuron and promotes inflammatory heat hyperalgesia.
Title: Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron.
the results indicate that Nogo-A influences NGF-mediated mechanisms involving the activation of TrkA and its interaction with p75(NTR).
Title: Nogo-A interacts with TrkA to alter nerve growth factor signaling in Nogo-A-overexpressing PC12 cells.

Submit: New GeneRIF Correction See all GeneRIFs (72)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143221 (e-PCR)
- UniSTS:232468

RH140746 (e-PCR)
- UniSTS:222812

Rtn4 (e-PCR), detects polymorphism
- UniSTS:547532

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axonal fasciculation	IDA Inferred from Direct Assay more info	PubMed
involved_in axonal fasciculation	IEA Inferred from Electronic Annotation more info
involved_in axonal fasciculation	ISO Inferred from Sequence Orthology more info
involved_in blastocyst formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blastocyst formation	ISO Inferred from Sequence Orthology more info
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration involved in vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell migration involved in vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in central nervous system vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in central nervous system vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebral cortex radial glia-guided migration	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex radial glia-guided migration	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex radial glia-guided migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum organization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum tubular network formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum tubular network formation	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum tubular network formation	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum tubular network formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum tubular network membrane organization	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum tubular network membrane organization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum tubular network membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum tubular network organization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum tubular network organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular sphingolipid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular sphingolipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of axon extension	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of axon extension	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axon extension	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron projection regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear pore complex assembly	IEA Inferred from Electronic Annotation more info
involved_in nuclear pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in nuclear pore complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in olfactory nerve development	IEP Inferred from Expression Pattern more info	PubMed
involved_in oligodendrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of ERBB3 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERBB3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rac protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of artery morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macrophage migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mammary gland epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 9 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of toll-like receptor 9 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 9 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to lysosome	IEA Inferred from Electronic Annotation more info
involved_in protein localization to lysosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to lysosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of branching morphogenesis of a nerve	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of branching morphogenesis of a nerve	IEA Inferred from Electronic Annotation more info
involved_in regulation of branching morphogenesis of a nerve	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of nervous system development	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum tubular network membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum tubular network membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum tubular network membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: reticulon-4

Names: GLUT4 vesicle 20kDa protein; NI-220/250; foocen; glut4 vesicle 20 kDa protein; neurite outgrowth inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.