STK35 serine/threonine kinase 35 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STK35provided by HGNC
Official Full Name: serine/threonine kinase 35provided by HGNC
Primary source: HGNC:HGNC:16254
See related: Ensembl:ENSG00000125834 MIM:609370; AllianceGenome:HGNC:16254
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CLIK1; STK35L1
Summary: The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 8.0), esophagus (RPKM 4.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20p13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (2101827..2148555)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (2131852..2178591)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (2082473..2129201)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.
Title: SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.
STK35 knockdown enhanced apoptosis. Expression of the active forms and the activity of two major executioner caspases, caspase 3 and caspase 7, were also increased in osteosarcoma cells with STK35 silenced.
Title: Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells.
constitutive overexpression of STK35 proteins enhances caspase-independent cell death under oxidative stress conditions.
Title: Nuclear retention of importin α coordinates cell fate through changes in gene expression.
by regulating CDKN2A and inhibiting G1- to S-phase transition STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells
Title: STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells.
analysis of the STK35L proteins in human and in sea squirts
Title: Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates.
results establish the CLP-36 PDZ-LIM protein as an adapter, recruiting the Clik1 kinase to actin stress fibers in nonmuscle cells, and suggest that Clik1 represents a novel regulator of actin stress fibers
Title: Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489985

G65619 (e-PCR)
- UniSTS:225555

RH119388 (e-PCR)
- UniSTS:132929

NoName (e-PCR)
- UniSTS:480674

A006Y25 (e-PCR)
- UniSTS:5564

D10S409E (e-PCR)
- UniSTS:473026

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of translational initiation by eIF2 alpha phosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase 35

Names: CLIK-1; CLP-36 interacting kinase; CLP-36-interacting kinase 1; PDLIM1-interacting kinase 1; serine threonine kinase 35 long form; serine/threonine-protein kinase 35 L1

NP_543026.2

EC 2.7.11.1

XP_011527476.2

EC 2.7.11.1

XP_054179044.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080836.4 → NP_543026.2 serine/threonine-protein kinase 35

See identical proteins and their annotated locations for NP_543026.2

Status: REVIEWED

Source sequence(s)

AL359916, BC140884, GQ281297

Consensus CDS

CCDS13024.2

UniProtKB/Swiss-Prot

B2RBM3, C7ENV8, Q2NKW6, Q5T3R1, Q5T3R2, Q8TDR2, Q96AB4, Q9BZ06

Related

ENSP00000370891.3, ENST00000381482.8

Conserved Domains (2) summary

smart00220
Location:202 → 523

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13977
Location:201 → 529

STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like