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    CASC11 cancer susceptibility 11 [ Homo sapiens (human) ]

    Gene ID: 100270680, updated on 10-Oct-2023

    Summary

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    Official Symbol
    CASC11provided by HGNC
    Official Full Name
    cancer susceptibility 11provided by HGNC
    Primary source
    HGNC:HGNC:48939
    See related
    Ensembl:ENSG00000249375 MIM:617704; AllianceGenome:HGNC:48939
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYMLR; CARLO7; CARLo-7; LINC00990; TCONS_00014535
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    8q24.21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (127700608..127733967, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (128828063..128861419, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (128712853..128746213, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene cancer susceptibility 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27941 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:128444461-128445375 Neighboring gene POU class 5 homeobox 1B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19528 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:128620950-128621545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27946 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128658093-128658594 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128658595-128659094 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:128672691-128673890 Neighboring gene uncharacterized LOC105375754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128681305-128681805 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128717643-128718143 Neighboring gene NANOG hESC enhancer GRCh37_chr8:128744882-128745383 Neighboring gene origin of replication upstream of MYC Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19530 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:128754894-128756093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128805180-128805750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19533 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128806893-128807462 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128807463-128808034 Neighboring gene MYC proto-oncogene, bHLH transcription factor Neighboring gene microRNA 1204 Neighboring gene Pvt1 oncogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Role of LncRNA CASC11 in the malignant transformation of 16HBE cells induced by glycidyl methacrylate]. Wang M, et al. Wei Sheng Yan Jiu, 2021 Nov. PMID 34949331
    2. CASC11 promotes aggressiveness of prostate cancer cells through miR-145/IGF1R axis. Capik O, et al. Prostate Cancer Prostatic Dis, 2021 Sep. PMID 33753875
    3. LncRNA CASC11 promotes the development of esophageal carcinoma by regulating KLF6. Chen SG, et al. Eur Rev Med Pharmacol Sci, 2019 Oct. PMID 31696474
    4. Silencing CASC11 curbs neonatal neuroblastoma progression through modulating microRNA-676-3p/nucleolar protein 4 like (NOL4L) axis. Yu Z, et al. Pediatr Res, 2020 Mar. PMID 31645055
    5. LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α. Yu H, et al. Clin Interv Aging, 2019. PMID 31571846, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low-density lipoprotein-induced injury of cardiac microvascular endothelial cells.
      Title: LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low-density lipoprotein-induced injury of cardiac microvascular endothelial cells.
    2. Correlation between plasma lncRNA CASC11 and malignancy in lung adenocarcinoma patients and the prognostic value of lncRNA CASC11.
      Title: Correlation between plasma lncRNA CASC11 and malignancy in lung adenocarcinoma patients and the prognostic value of lncRNA CASC11.
    3. LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p.
      Title: LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p.
    4. Long noncoding RNA CASC11 interacts with YBX1 to promote prostate cancer progression by suppressing the p53 pathway.
      Title: Long non‑coding RNA CASC11 interacts with YBX1 to promote prostate cancer progression by suppressing the p53 pathway.
    5. CASC11 promotes aggressiveness of prostate cancer cells through miR-145/IGF1R axis.
      Title: CASC11 promotes aggressiveness of prostate cancer cells through miR-145/IGF1R axis.
    6. [Role of LncRNA CASC11 in the malignant transformation of 16HBE cells induced by glycidyl methacrylate].
      Title: [Role of LncRNA CASC11 in the malignant transformation of 16HBE cells induced by glycidyl methacrylate].
    7. Contribution of lncRNA CASC8, CASC11, and PVT1 Genetic Variants to the Susceptibility of Coronary Heart Disease.
      Title: Contribution of lncRNA CASC8, CASC11, and PVT1 Genetic Variants to the Susceptibility of Coronary Heart Disease.
    8. Silencing CASC11 curbs neonatal neuroblastoma progression through modulating microRNA-676-3p/nucleolar protein 4 like (NOL4L) axis.
      Title: Silencing CASC11 curbs neonatal neuroblastoma progression through modulating microRNA-676-3p/nucleolar protein 4 like (NOL4L) axis.
    9. LncRNA CASC11 was downregulated in coronary artery disease and inhibits transforming growth factor-beta1.
      Title: LncRNA CASC11 was downregulated in coronary artery disease and inhibits transforming growth factor-β1.
    10. LncRNA CASC11 promotes the development of esophageal carcinoma by regulating KLF6.
      Title: LncRNA CASC11 promotes the development of esophageal carcinoma by regulating KLF6.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Other Names

    • MYC-modulating lncRNA
    • cancer susceptibility 11 (non-protein coding)
    • cancer susceptibility candidate 11 (non-protein coding)
    • long intergenic non-protein coding RNA 990

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_117101.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC103819
      Related
      ENST00000518376.2

    2. NR_117102.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and contains three alternate 3' exons, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC103819, AC108925
      Related
      ENST00000519071.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      127700608..127733967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      128828063..128861419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases