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    LIPJ lipase family member J [ Homo sapiens (human) ]

    Gene ID: 142910, updated on 5-Mar-2024

    Summary

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    Official Symbol
    LIPJprovided by HGNC
    Official Full Name
    lipase family member Jprovided by HGNC
    Primary source
    HGNC:HGNC:21773
    See related
    Ensembl:ENSG00000204022 MIM:613921; AllianceGenome:HGNC:21773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIPL1; bA425M17.2
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in lipid catabolic process. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 1.7), thyroid (RPKM 0.3) and 20 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    10q23.31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88582907..88623184)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89466981..89507284)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90342664..90366733)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378416 Neighboring gene uncharacterized LOC101929727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3720 Neighboring gene renalase, FAD dependent amine oxidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3722 Neighboring gene vomeronasal 1 receptor 55 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:90107282-90107945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3724 Neighboring gene ribosomal protein L7 pseudogene 34 Neighboring gene lipase F, gastric type Neighboring gene N-ethylmaleimide-sensitive factor attachment protein, gamma pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Homology

    Clone Names

    • FLJ11218

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lipase member J
    Names
    lipase J
    lipase-like abhydrolase domain-containing protein 1
    lipase-like, ab-hydrolase domain containing 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010939.3 → NP_001010939.2  lipase member J isoform 1

      See identical proteins and their annotated locations for NP_001010939.2

      Status: VALIDATED

      Source sequence(s)
      AL139406
      Consensus CDS
      CCDS31240.1
      UniProtKB/Swiss-Prot
      A8MT98, Q0P671, Q5W064
      Related
      ENSP00000361007.3, ENST00000371939.7
      Conserved Domains (3) summary
      pfam00561
      Location:48 → 347
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:3 → 66
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:47 → 209
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_001394640.1 → NP_001381569.1  lipase member J isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL139406
      Conserved Domains (1) summary
      PLN02872
      Location:4 → 310
      PLN02872; triacylglycerol lipase

    RNA

    1. NR_172141.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139406

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      88582907..88623184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717635.4 → XP_006717698.1  lipase member J isoform X1

      See identical proteins and their annotated locations for XP_006717698.1

      UniProtKB/Swiss-Prot
      A8MT98, Q0P671, Q5W064
      Conserved Domains (3) summary
      pfam00561
      Location:48 → 347
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:3 → 66
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:47 → 209
      Abhydrolase_5; Alpha/beta hydrolase family

    2. XM_047424642.1 → XP_047280598.1  lipase member J isoform X2

    3. XM_047424643.1 → XP_047280599.1  lipase member J isoform X3

    4. XM_011539315.2 → XP_011537617.1  lipase member J isoform X1

      See identical proteins and their annotated locations for XP_011537617.1

      UniProtKB/Swiss-Prot
      A8MT98, Q0P671, Q5W064
      Conserved Domains (3) summary
      pfam00561
      Location:48 → 347
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:3 → 66
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:47 → 209
      Abhydrolase_5; Alpha/beta hydrolase family

    5. XM_005269542.3 → XP_005269599.1  lipase member J isoform X4

      Conserved Domains (1) summary
      PLN02872
      Location:1 → 246
      PLN02872; triacylglycerol lipase

    6. XM_011539319.1 → XP_011537621.1  lipase member J isoform X6

      See identical proteins and their annotated locations for XP_011537621.1

      Conserved Domains (1) summary
      PLN02872
      Location:57 → 177
      PLN02872; triacylglycerol lipase

    7. XM_011539318.2 → XP_011537620.1  lipase member J isoform X5

      Conserved Domains (1) summary
      PLN02872
      Location:98 → 218
      PLN02872; triacylglycerol lipase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      89466981..89507284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364875.1 → XP_054220850.1  lipase member J isoform X1

    2. XM_054364877.1 → XP_054220852.1  lipase member J isoform X2

    3. XM_054364878.1 → XP_054220853.1  lipase member J isoform X3

    4. XM_054364876.1 → XP_054220851.1  lipase member J isoform X1

    5. XM_054364879.1 → XP_054220854.1  lipase member J isoform X4

    6. XM_054364881.1 → XP_054220856.1  lipase member J isoform X6

    7. XM_054364880.1 → XP_054220855.1  lipase member J isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5W064.3 GenPept UniProtKB/Swiss-Prot:Q5W064

    Gene LinkOut

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