Golga2 golgin A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Golga2provided by RGD
Official Full Name: golgin A2provided by RGD
Primary source: RGD:620282
See related: Ensembl:ENSRNOG00000011884 AllianceGenome:RGD:620282
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gm130
Summary: Enables importin-alpha family protein binding activity and protein kinase binding activity. Involved in several processes, including Golgi disassembly; mitotic spindle assembly; and protein homotetramerization. Located in Golgi apparatus and neuronal cell body. Part of protein-containing complex. Orthologous to several human genes including GOLGA2 (golgin A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 140.0), Lung (RPKM 129.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (35981783..36002023)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (15583862..15604279)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (11317328..11337569)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serine 25 phosphorylation of GM130 independent pathways ensure Golgi vesiculation and mitotic progression.
Title: Mitotic Golgi vesiculation involves mechanisms independent of Ser25 phosphorylation of GM130.
depletion of GM130 by RNA interference slows the rate of ER to Golgi trafficking in vivo; interactions of GM130 with syntaxin 5 and Rab1 are regulated by mitotic phosphorylation
Title: Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner.
GM130 and BB-CK co-localize specifically in a transient fashion during early prophase of mitosis, when GM130 plays an important role in Golgi fragmentation that starts also at early prophase.
Title: Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables importin-alpha family protein binding	IDA Inferred from Direct Assay more info	PubMed
enables importin-alpha family protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi disassembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Golgi localization	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in Golgi ribbon formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in asymmetric cell division	ISO Inferred from Sequence Orthology more info
involved_in asymmetric cell division	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
involved_in meiotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in meiotic spindle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in microtubule nucleation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in spindle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in COPII-coated ER to Golgi transport vesicle	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi cis cisterna	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cis cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi cis cisterna	ISO Inferred from Sequence Orthology more info
is_active_in Golgi cisterna membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cisterna membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	TAS Traceable Author Statement more info
is_active_in cis-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in cis-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in cis-Golgi network	IEA Inferred from Electronic Annotation more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: golgin subfamily A member 2

Names: 130 kDa cis-Golgi matrix protein; cis-Golgi matrix protein GM130; golgi autoantigen, golgin subfamily a, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022596.2 → NP_072118.2 golgin subfamily A member 2

Status: VALIDATED

Source sequence(s)

AA899518, FN805702, FN805927, FQ147221, JAXUCZ010000003, U35022

UniProtKB/TrEMBL

A0A140TAB6

Related

ENSRNOP00000078482.1, ENSRNOT00000106907.1

Conserved Domains (2) summary

pfam15070
Location:381 → 997

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

cl11423
Location:206 → 306

VirB9_CagX_TrbG; VirB9/CagX/TrbG, a component of the type IV secretion system

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

35981783..36002023

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233992.5 → XP_006234054.1 golgin subfamily A member 2 isoform X1

UniProtKB/TrEMBL

A6JU51

Conserved Domains (2) summary

pfam15070
Location:408 → 1037

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

cl11423
Location:233 → 333

VirB9_CagX_TrbG; VirB9/CagX/TrbG, a component of the type IV secretion system
XM_006233993.5 → XP_006234055.1 golgin subfamily A member 2 isoform X2

UniProtKB/TrEMBL

A0A0G2K977, A0A140TAB6

Related

ENSRNOP00000074890.1

Conserved Domains (2) summary

pfam15070
Location:408 → 1026

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

cl11423
Location:233 → 333

VirB9_CagX_TrbG; VirB9/CagX/TrbG, a component of the type IV secretion system
XM_006233994.5 → XP_006234056.1 golgin subfamily A member 2 isoform X3

UniProtKB/TrEMBL

A0A140TAB6

Related

ENSRNOP00000079188.1

Conserved Domains (2) summary

pfam15070
Location:408 → 1025

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

cl11423
Location:233 → 333

VirB9_CagX_TrbG; VirB9/CagX/TrbG, a component of the type IV secretion system
XM_006233996.5 → XP_006234058.1 golgin subfamily A member 2 isoform X5

UniProtKB/TrEMBL

A6JU51

Conserved Domains (2) summary

pfam15070
Location:381 → 1010

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

cl11423
Location:206 → 306

VirB9_CagX_TrbG; VirB9/CagX/TrbG, a component of the type IV secretion system
XM_039105792.2 → XP_038961720.1 golgin subfamily A member 2 isoform X9

UniProtKB/TrEMBL

A0A8I6G694, A6JU51

Related

ENSRNOP00000080186.1

Conserved Domains (3) summary

TIGR02168
Location:148 → 445

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15070
Location:381 → 905

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

pfam19046
Location:950 → 995

GM130_C; GM130 C-terminal binding motif
XM_063284520.1 → XP_063140590.1 golgin subfamily A member 2 isoform X8

UniProtKB/TrEMBL

A6JU51
XM_006233995.5 → XP_006234057.1 golgin subfamily A member 2 isoform X4

UniProtKB/TrEMBL

A0A140TAB6

Conserved Domains (2) summary

pfam15070
Location:381 → 1010

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

cl11423
Location:206 → 306

VirB9_CagX_TrbG; VirB9/CagX/TrbG, a component of the type IV secretion system
XM_006233997.5 → XP_006234059.1 golgin subfamily A member 2 isoform X6

UniProtKB/TrEMBL

A0A140TAB6

Conserved Domains (2) summary

pfam15070
Location:381 → 999

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

cl11423
Location:206 → 306

VirB9_CagX_TrbG; VirB9/CagX/TrbG, a component of the type IV secretion system
XM_006233998.5 → XP_006234060.1 golgin subfamily A member 2 isoform X7

See identical proteins and their annotated locations for XP_006234060.1

UniProtKB/Swiss-Prot

F1LSS0, Q62839

UniProtKB/TrEMBL

A0A140TAB6, A6JU52

Related

ENSRNOP00000016341.7

Conserved Domains (2) summary

pfam15070
Location:381 → 998

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

cl11423
Location:206 → 306

VirB9_CagX_TrbG; VirB9/CagX/TrbG, a component of the type IV secretion system
XM_063284521.1 → XP_063140591.1 golgin subfamily A member 2 isoform X10

UniProtKB/TrEMBL

A0A140TAB6
XM_039105794.2 → XP_038961722.1 golgin subfamily A member 2 isoform X12

UniProtKB/TrEMBL

A0A140TAB6

Conserved Domains (3) summary

TIGR02168
Location:121 → 418

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15070
Location:354 → 878

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

pfam19046
Location:923 → 968

GM130_C; GM130 C-terminal binding motif
XM_039105793.2 → XP_038961721.1 golgin subfamily A member 2 isoform X11

UniProtKB/TrEMBL

A6JU53

Conserved Domains (3) summary

TIGR02168
Location:119 → 413

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15070
Location:349 → 884

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

pfam19046
Location:929 → 974

GM130_C; GM130 C-terminal binding motif
XM_039105795.2 → XP_038961723.1 golgin subfamily A member 2 isoform X13

UniProtKB/TrEMBL

A6JU53

Related

ENSRNOP00000087352.1

Conserved Domains (3) summary

TIGR02168
Location:119 → 413

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15070
Location:349 → 873

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

pfam19046
Location:918 → 963

GM130_C; GM130 C-terminal binding motif
XM_063284522.1 → XP_063140592.1 golgin subfamily A member 2 isoform X14

UniProtKB/TrEMBL

A6JU53
XM_039105796.2 → XP_038961724.1 golgin subfamily A member 2 isoform X15

UniProtKB/TrEMBL

A6JU53

Conserved Domains (3) summary

TIGR02168
Location:89 → 386

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15070
Location:322 → 846

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

pfam19046
Location:891 → 936

GM130_C; GM130 C-terminal binding motif
XM_039105797.2 → XP_038961725.1 golgin subfamily A member 2 isoform X16

UniProtKB/TrEMBL

A0A140TAB6

Conserved Domains (3) summary

TIGR02168
Location:65 → 359

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15070
Location:295 → 830

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

pfam19046
Location:875 → 920

GM130_C; GM130 C-terminal binding motif