fic-1 Protein adenylyltransferase fic-1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: fic-1
Gene description: Protein adenylyltransferase fic-1
Locus tag: CELE_ZK593.8
See related: AllianceGenome:WB:WBGene00014004
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein adenylyltransferase activity. Involved in defense response to Gram-negative bacterium and protein adenylylation. Located in endoplasmic reticulum and nuclear envelope. Is expressed widely. Orthologous to human FICD (FIC domain protein adenylyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See fic-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (10937454..10939934)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We identify a link between FIC-1-mediated AMPylation and susceptibility to the pathogen Pseudomonas aeruginosa, establishing a connection between AMPylation and innate immunity in C. elegans
Title: The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK593.8 (e-PCR)
- UniSTS:306255

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables AMPylase activity	IDA Inferred from Direct Assay more info	PubMed
enables AMPylase activity	IEA Inferred from Electronic Annotation more info
enables AMPylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein adenylylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein adenylyltransferase fic-1

NP_502036.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10937454..10939934

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069635.6 → NP_502036.1 Protein adenylyltransferase fic-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502036.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23544

Conserved Domains (4) summary

COG3177
Location:265 → 478

COG3177; Fic family protein [Transcription]

sd00006
Location:180 → 210

TPR; TPR repeat [structural motif]

pfam02661
Location:326 → 422

Fic; Fic/DOC family

pfam13414
Location:146 → 212

TPR_11; TPR repeat