Ccdc88a coiled coil domain containing 88A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccdc88aprovided by RGD
Official Full Name: coiled coil domain containing 88Aprovided by RGD
Primary source: RGD:1306694
See related: Ensembl:ENSRNOG00000004057 AllianceGenome:RGD:1306694
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ape; GIV; Hkrp1; RGD1306694
Summary: Enables G-protein gamma-subunit binding activity. Predicted to be involved in several processes, including activation of protein kinase B activity; intracellular signal transduction; and regulation of plasma membrane bounded cell projection organization. Located in COPI-coated Golgi to ER transport vesicle. Orthologous to human CCDC88A (coiled-coil domain containing 88A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 225.9), Testes (RPKM 170.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (107304654..107456104)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (103104091..103256112)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (113771093..113936376)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin.
Title: GIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin.
Girdin is upregulated and phosphorylated in the neointima of rat carotid arteries after vascular injury.
Title: The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury.
A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.
Title: A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.
The present data provide further in vivo evidence for the crucial role of particle surface properties in quartz dust-induced ROS/RNS generation by recruited inflammatory phagocytes.
Title: The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species formation and APE/Ref-1 induction in rat lung.
HkRP1 is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains [HkRP1]
Title: A novel hook-related protein family and the characterization of hook-related protein 1.
GIV is a novel Galpha-interacting protein associated with COPI transport vesicles that may play a role in Galpha-mediated effects on vesicle trafficking within the Golgi and/or between the ER and the Golgi
Title: Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles.

Submit: New GeneRIF Correction

General gene information

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Markers

BE106537 (e-PCR)
- UniSTS:246304

Ccdc88a (e-PCR), detects polymorphism
- UniSTS:506689

RH128278 (e-PCR)
- UniSTS:211586

RH133705 (e-PCR)
- UniSTS:216988

RH143665 (e-PCR)
- UniSTS:232911

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables G-protein gamma-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase B binding	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor 2 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton-dependent intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in maintenance of protein location in plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in membrane organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in COPI-coated Golgi to ER transport vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: girdin

Names: Akt-phosphorylation enhancer; Galpha-interacting vesicle-associated protein; Hook-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427796.1 → NP_001414725.1 girdin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

107304654..107456104

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008770470.4 → XP_008768692.2 girdin isoform X1

UniProtKB/TrEMBL

A0A8I6A5W7, A6JQB3

Related

ENSRNOP00000086390.1

Conserved Domains (3) summary

COG1196
Location:474 → 1331

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK03918
Location:249 → 685

PRK03918; DNA double-strand break repair ATPase Rad50

cd22229
Location:10 → 165

HkD_Girdin; Hook domain found in Girdin and similar proteins
XM_039092893.2 → XP_038948821.1 girdin isoform X2

UniProtKB/TrEMBL

A0A8I5ZW24, A6JQB3

Related

ENSRNOP00000083554.1

Conserved Domains (3) summary

COG1196
Location:474 → 1331

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK03918
Location:249 → 685

PRK03918; DNA double-strand break repair ATPase Rad50

cd22229
Location:10 → 165

HkD_Girdin; Hook domain found in Girdin and similar proteins
XM_063273284.1 → XP_063129354.1 girdin isoform X3
XM_063273285.1 → XP_063129355.1 girdin isoform X4
XM_063273287.1 → XP_063129357.1 girdin isoform X5