unc-2 EF-hand domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: unc-2
Gene description: EF-hand domain-containing protein
Primary source: WormBase:WBGene00006742
Locus tag: CELE_T02C5.5
See related: AllianceGenome:WB:WBGene00006742
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable voltage-gated calcium channel activity. Involved in several processes, including determination of left/right asymmetry in nervous system; negative regulation of transforming growth factor beta receptor signaling pathway; and response to heat. Located in presynaptic active zone membrane. Is expressed in several structures, including body wall musculature; excretory canal; head; neurons; and pharyngeal muscle cell. Used to study migraine. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; brain disease (multiple); and episodic ataxia type 2. Orthologous to several human genes including CACNA1A (calcium voltage-gated channel subunit alpha1 A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See unc-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 40

Sequence:: Chromosome: X; NC_003284.9 (2710920..2763526, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These studies reveal mechanisms through which UNC2 gain-of-function mutations disrupt excitation-inhibition balance in the nervous system.
Title: Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans.
SLO-1 and SLO-2 localize close to UNC-2 and EGL-19 in AWC, suggesting a role of possible functional coupling between SLO BK channels and voltage-activated calcium channels in AWC asymmetry.
Title: SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification.
UNC-2 calcium channels that provide calcium ions for neurotransmitter release influence the localization specificity of the SLO-1 channel clusters at presynaptic terminals
Title: Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels.
identified UNC-2/UNC-36 voltage-gated calcium channels and UNC-43/CaMKII as regulators of C. elegans synaptogenesis
Title: The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology.
UNC-2 plays a pivotal role in mediating a number of physiological processes in the nematode; mutational analysis revealed critical residues important for calcium channel function in vivo
Title: Critical residues of the Caenorhabditis elegans unc-2 voltage-gated calcium channel that affect behavioral and physiological properties.
Transgenic expression of the migraine-associated Ca2+ channel, CACNA1A, in unc-2 animals can functionally substitute for UNC-2 in stress-activated regulation of tryptophan hydroxylase expression
Title: The voltage-gated calcium channel UNC-2 is involved in stress-mediated regulation of tryptophan hydroxylase.

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General gene information

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Markers

STS6-120 (e-PCR)
- UniSTS:242500

T02C5.5 (e-PCR)
- UniSTS:310610

F25H10.1 (e-PCR)
- UniSTS:316627

T02C5.4 (e-PCR)
- UniSTS:314850

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of left/right asymmetry in nervous system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of left/right asymmetry in nervous system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: EF-hand domain-containing protein

NP_001335515.1

Confirmed by transcript evidence

NP_001335516.1

Confirmed by transcript evidence

NP_001335560.1

Confirmed by transcript evidence

NP_001335561.1

Confirmed by transcript evidence

NP_001335562.1

Confirmed by transcript evidence

NP_001335563.1

Confirmed by transcript evidence

NP_001335570.1

Partially confirmed by transcript evidence

NP_001335571.1

Partially confirmed by transcript evidence

NP_001335572.1

Partially confirmed by transcript evidence

NP_001335573.1

Partially confirmed by transcript evidence

NP_001355462.1

Partially confirmed by transcript evidence

NP_001355463.1

Partially confirmed by transcript evidence

NP_001355464.1

Partially confirmed by transcript evidence

NP_001355494.1

Partially confirmed by transcript evidence

NP_741732.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

2710920..2763526 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171638.3 → NP_741732.2 EF-hand domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741732.2

Status: REVIEWED

UniProtKB/TrEMBL

Q86G45, Q8MPY6

Conserved Domains (3) summary

pfam00520
Location:1179 → 1433

Ion_trans; Ion transport protein

pfam08763
Location:1506 → 1582

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1442 → 1495

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001348592.5 → NP_001335571.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1N7SYU4

Conserved Domains (4) summary

pfam05539
Location:1885 → 2042

Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G

pfam00520
Location:1201 → 1455

Ion_trans; Ion transport protein

pfam08763
Location:1528 → 1604

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1464 → 1517

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001348596.5 → NP_001335516.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8MPY5

Conserved Domains (3) summary

pfam00520
Location:1045 → 1299

Ion_trans; Ion transport protein

pfam08763
Location:1372 → 1448

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1308 → 1361

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001348594.5 → NP_001335570.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1N7SYU0

Conserved Domains (4) summary

pfam05539
Location:1903 → 2060

Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G

pfam00520
Location:1201 → 1455

Ion_trans; Ion transport protein

pfam08763
Location:1528 → 1604

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1464 → 1517

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001368494.4 → NP_001355464.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E663

Conserved Domains (3) summary

pfam00520
Location:1323 → 1577

Ion_trans; Ion transport protein

pfam08763
Location:1650 → 1726

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1586 → 1639

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001368495.4 → NP_001355463.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1DR32

Conserved Domains (3) summary

pfam00520
Location:1271 → 1525

Ion_trans; Ion transport protein

pfam08763
Location:1598 → 1674

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1534 → 1587

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001368496.4 → NP_001355462.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E4Z9

Conserved Domains (3) summary

pfam00520
Location:1279 → 1533

Ion_trans; Ion transport protein

pfam08763
Location:1606 → 1682

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1542 → 1595

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001348588.4 → NP_001335561.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1N7SYT0

Conserved Domains (4) summary

pfam05539
Location:1820 → 1977

Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G

pfam00520
Location:1136 → 1390

Ion_trans; Ion transport protein

pfam08763
Location:1463 → 1539

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1399 → 1452

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001348589.4 → NP_001335563.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1N7SYU6

Conserved Domains (3) summary

pfam00520
Location:1136 → 1390

Ion_trans; Ion transport protein

pfam08763
Location:1463 → 1539

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1399 → 1452

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001348590.4 → NP_001335560.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1N7SYV5

Conserved Domains (4) summary

pfam05539
Location:1838 → 1995

Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G

pfam00520
Location:1136 → 1390

Ion_trans; Ion transport protein

pfam08763
Location:1463 → 1539

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1399 → 1452

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001348591.4 → NP_001335562.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1N7SYT1

Conserved Domains (3) summary

pfam00520
Location:1136 → 1390

Ion_trans; Ion transport protein

pfam08763
Location:1463 → 1539

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1399 → 1452

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001348593.4 → NP_001335573.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1N7SYT8

Conserved Domains (3) summary

pfam00520
Location:1201 → 1455

Ion_trans; Ion transport protein

pfam08763
Location:1528 → 1604

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1464 → 1517

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001348595.4 → NP_001335572.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1N7SYV7

Conserved Domains (3) summary

pfam00520
Location:1201 → 1455

Ion_trans; Ion transport protein

pfam08763
Location:1528 → 1604

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1464 → 1517

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001368497.5 → NP_001355494.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E695

Conserved Domains (3) summary

pfam00520
Location:1137 → 1391

Ion_trans; Ion transport protein

pfam08763
Location:1464 → 1540

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1400 → 1453

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001348597.2 → NP_001335515.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EFB0

Conserved Domains (3) summary

pfam00520
Location:1045 → 1299

Ion_trans; Ion transport protein

pfam08763
Location:1372 → 1448

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1308 → 1361

GPHH; Voltage-dependent L-type calcium channel, IQ-associated