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    a2ml3 alpha-2-macroglobulin-like 3 [ Danio rerio (zebrafish) ]

    Gene ID: 100006947, updated on 20-Apr-2024

    Summary

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    Official Symbol
    a2ml3provided by ZNC
    Official Full Name
    alpha-2-macroglobulin-like 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9800
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-9800
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb37; im:7000403; wu:fb66f01
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. Is expressed in yolk syncytial layer. [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    not in current annotation release
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    Genomic context

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    See a2ml3 in Genome Data Viewer
    Location:
    chromosome: 15
    Annotation release Status Assembly Chr Location
    105 latest, but not current GRCz10 (GCF_000002035.5) 15 NC_007126.6 (21201314..21219932, complement)

    Bibliography

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    Related articles in PubMed

    1. Dynamic evolutionary pattern of alpha2-macroglobulin in a model organism, the zebrafish (Danio rerio). Padhi A, et al. Mol Immunol, 2008 Jun. PMID 18485482
    2. Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. Lam SH, et al. BMC Med Genomics, 2011 May 16. PMID 21575170, Free PMC Article
    3. High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Niksirat H, et al. J Proteome Res, 2021 Aug 6. PMID 34185526
    4. Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. Zheng W, et al. PLoS One, 2013. PMID 23349717, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    General protein information

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    Preferred Names
    alpha-2-macroglobulin
    Names
    a2m

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386282.1 → NP_001373211.1  alpha-2-macroglobulin precursor

      Status: VALIDATED

      Source sequence(s)
      CR626907
      UniProtKB/TrEMBL
      A0A8M9QPQ0
      Conserved Domains (5) summary
      COG2373
      Location:128 → 1430
      YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
      cd02897
      Location:948 → 1234
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:729 → 817
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1341 → 1431
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:459 → 609
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein
    Heading Accession and Version

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