DEFB1 defensin beta 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: DEFB1provided by VGNC
Official Full Name: defensin beta 1provided by VGNC
Primary source: VGNC:VGNC:87240
See related: Ensembl:ENSSSCG00000029990
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: PBD-2
Expression: Biased expression in kidney (RPKM 390.0), mixtures (RPKM 90.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: chromosome: Un

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	Unplaced Scaffold	NW_018085039.1 (558..11154)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	15	NC_010457.4 (43346359..43356953)

NW_018085039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptome Analysis Reveals the Multiple Functions of pBD2 in IPEC-J2 Cells against E. coli.
Title: Transcriptome Analysis Reveals the Multiple Functions of pBD2 in IPEC-J2 Cells against E. coli.
Porcine beta-defensin 2 inhibits proliferation of pseudorabies virus in vitro and in transgenic mice.
Title: Porcine β-defensin 2 inhibits proliferation of pseudorabies virus in vitro and in transgenic mice.
The results demonstrate that transgenic overexpression of PBD-2 in pigs confers enhanced resistance against Actinobacillus pleuropneumoniae infection.
Title: Overexpression of Porcine Beta-Defensin 2 Enhances Resistance to Actinobacillus pleuropneumoniae Infection in Pigs.
Zinc sulfate and L-isoleucine induce beta defensin expression in a porcine cell line.
Title: Zn(2+) and L-isoleucine induce the expressions of porcine β-defensins in IPEC-J2 cells.
pBD-2 may be an important defense molecule for intestinal health.
Title: Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CCR6 chemokine receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response in mucosa	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-defensin 1

Names: beta-defensin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.