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    Dna2 DNA replication helicase/nuclease 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31934, updated on 10-May-2024

    Summary

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    Official Symbol
    Dna2provided by FlyBase
    Official Full Name
    DNA replication helicase/nuclease 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0288690
    Locus tag
    Dmel_CG2990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2990; DmDNA2; Dmel\CG2990; DNA2; l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107; mus109
    Orthologs
    all
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    Genomic context

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    See Dna2 in Genome Data Viewer
    Location:
    9A4-9A4; 1-30 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10010481..10014279)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9904514..9908312)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chitinase 6 Neighboring gene antisense RNA:CR45185 Neighboring gene Yolk protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Mutagen-Sensitivity Gene mus109 Encodes DmDNA2. Mitchell C, et al. Genes (Basel), 2022 Feb 7. PMID 35205357, Free PMC Article
    2. Isolation of two X-linked mutants in Drosophila melanogaster which are sensitive to gamma-rays. Nguyen TD, et al. Mutat Res, 1978 Jan. PMID 414131
    3. The maxillary palp of Drosophila: ultrastructure and physiology depends on the lozenge gene. Riesgo-Escovar JR, et al. J Comp Physiol A, 1997 Feb. PMID 9011067
    4. Mutagen sensitivity of Drosophila melanogaster. III. X-linked loci governing sensitivity to methyl methanesulfonate. Smith PD. Mol Gen Genet, 1976 Nov 24. PMID 189178
    5. Identification of a new locus, mus115, in Drosophila melanogaster. Leonhardt EA, et al. Mutat Res, 1993 Feb. PMID 7678169

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 5'-flap endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication helicase/nuclease 2
    Names
    CG2990-PB
    CG2990-PC
    DNA helicase
    Dna2-PB
    Dna2-PC
    mutagen-sensitive 109
    NP_001096933.1
    NP_727386.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10010481..10014279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167214.2 → NP_727386.1  DNA replication helicase/nuclease 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727386.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH96, Q8IRL9
      Related
      FBpp0071350
      Conserved Domains (5) summary
      TIGR00376
      Location:480 → 1069
      TIGR00376; DNA helicase, putative
      pfam08696
      Location:99 → 297
      Dna2; DNA replication factor Dna2
      pfam13087
      Location:815 → 1055
      AAA_12; AAA domain
      cl00641
      Location:283 → 415
      Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
      cl21455
      Location:636 → 859
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001103463.2 → NP_001096933.1  DNA replication helicase/nuclease 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH96, Q9W2Z4
      Conserved Domains (5) summary
      TIGR00376
      Location:479 → 1068
      TIGR00376; DNA helicase, putative
      pfam08696
      Location:99 → 296
      Dna2; DNA replication factor Dna2
      pfam13087
      Location:814 → 1054
      AAA_12; AAA domain
      cl00641
      Location:282 → 414
      Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
      cl21455
      Location:635 → 858
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86D36 Q86D36
    Q8IRL9 Q8IRL9
    Q9W2Z4 Q9W2Z4

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