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    PATR-E major histocompatibility complex, class I, E [ Pan troglodytes (chimpanzee) ]

    Gene ID: 462540, updated on 3-Apr-2024

    Summary

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    Gene symbol
    PATR-E
    Gene description
    major histocompatibility complex, class I, E
    Locus tag
    CK820_G0006754
    See related
    Ensembl:ENSPTRG00000038986
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 5 NC_072403.2 (36368369..36373229)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 6 NC_072404.1 (36368376..36373236)

    Chromosome 5 - NC_072403.2Genomic Context describing neighboring genes Neighboring gene succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial-like Neighboring gene GTP-binding nuclear protein Ran-like Neighboring gene G protein nucleolar 1 (putative) Neighboring gene proline rich 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic analysis of common chimpanzee major histocompatibility complex class I genes. Adams EJ, et al. Immunogenetics, 2001 Apr. PMID 11398964
    2. Primate Mhc-E and -G alleles. Arnaiz-Villena A, et al. Immunogenetics, 1997. PMID 9218527
    3. Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence. Anzai T, et al. Proc Natl Acad Sci U S A, 2003 Jun 24. PMID 12799463, Free PMC Article
    4. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. Shiina T, et al. Genetics, 2006 Jul. PMID 16702430, Free PMC Article
    5. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables peptide antigen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    patr class I histocompatibility antigen, alpha chain E
    Names
    HLA class I histocompatibility antigen, alpha chain E
    MHC class I antigen E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045498.1 → NP_001038963.1  patr class I histocompatibility antigen, alpha chain E precursor

      See identical proteins and their annotated locations for NP_001038963.1

      Status: PROVISIONAL

      Source sequence(s)
      AF338354
      UniProtKB/Swiss-Prot
      Q95IT3
      UniProtKB/TrEMBL
      A0A2J8NX52, A0A663DHM6, G2HF20, Q1XHX0
      Related
      ENSPTRP00000054601.4, ENSPTRT00000062050.4
      Conserved Domains (2) summary
      cd07698
      Location:204 → 295
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:22 → 200
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072403.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      36368369..36373229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016954642.2 → XP_016810131.2  patr class I histocompatibility antigen, alpha chain E isoform X2

    2. XM_024356941.1 → XP_024212709.1  patr class I histocompatibility antigen, alpha chain E isoform X3

      UniProtKB/TrEMBL
      Q1XHX0
      Conserved Domains (2) summary
      cd07698
      Location:239 → 330
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:57 → 235
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    3. XM_009450819.2 → XP_009449094.1  patr class I histocompatibility antigen, alpha chain E isoform X4

      UniProtKB/TrEMBL
      Q1XHX0
      Conserved Domains (2) summary
      cd07698
      Location:239 → 331
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:57 → 235
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    4. XM_054685456.1 → XP_054541431.1  patr class I histocompatibility antigen, alpha chain E isoform X4

    5. XM_063811890.1 → XP_063667960.1  patr class I histocompatibility antigen, alpha chain E isoform X1

    Nucleotide Protein
    Heading Accession and Version

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