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    ankrd2 ankyrin repeat domain 2 (stretch responsive muscle) [ Danio rerio (zebrafish) ]

    Gene ID: 101886079, updated on 27-Mar-2024

    Summary

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    Official Symbol
    ankrd2provided by ZNC
    Official Full Name
    ankyrin repeat domain 2 (stretch responsive muscle)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090313-383
    See related
    Ensembl:ENSDARG00000002722 AllianceGenome:ZFIN:ZDB-GENE-090313-383
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkeyp-34h12.6
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in heart and skeletal muscle. Orthologous to human ANKRD2 (ankyrin repeat domain 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ankrd2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (40728869..40741033)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (40603729..40615143)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 7 Neighboring gene MORN repeat containing 4 Neighboring gene NK1 transcription factor related 2-like,a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Interaction of infectious spleen and kidney necrosis virus ORF119L with PINCH leads to dominant-negative inhibition of integrin-linked kinase and cardiovascular defects in zebrafish. Yuan JM, et al. J Virol, 2015 Jan. PMID 25355883, Free PMC Article
    2. Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise. Boskovic S, et al. PLoS One, 2018. PMID 30252882, Free PMC Article
    3. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. zebrafish (Danio rerio) muscle ankyrin repeat proteins
      Title: Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      40728869..40741033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480948.1 → XP_021336623.1  ankyrin repeat domain-containing protein 2-like

      UniProtKB/TrEMBL
      A0A8M9QAS9
      Related
      ENSDARP00000069315.4, ENSDART00000074829.5
      Conserved Domains (2) summary
      cd00204
      Location:135 → 260
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:174 → 204
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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