kcnb2.S potassium channel, voltage gated Shab related subfamily B, member 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: kcnb2.S
Official Full Name: potassium channel, voltage gated Shab related subfamily B, member 2 S homeolog
Primary source: Xenbase:XB-GENE-989395
Locus tag: XELAEV_18033794mg
See related: EnsemblRapid:ENSXLAG00005029997
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: kcnb2; kv2.2; XShab12; kcnb2-a; kcnb2-b
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Genomic context

Location:: chromosome: 6S

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6S	NC_054382.1 (106545062..106688962)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6S	NC_030735.1 (97881502..98026378)

Chromosome 6S - NC_054382.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mono-allelic KCNB2 variants lead to a neurodevelopmental syndrome caused by altered channel inactivation.
Title: Mono-allelic KCNB2 variants lead to a neurodevelopmental syndrome caused by altered channel inactivation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein homooligomerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: potassium channel, voltage gated Shab related subfamily B, member 2 S homeolog

Names: potassium voltage-gated channel, Shab-related subfamily, member 2, potassium channel alpha subunit Kv2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085787.1 → NP_001079256.1 potassium channel, voltage gated Shab related subfamily B, member 2 S homeolog

See identical proteins and their annotated locations for NP_001079256.1

Status: PROVISIONAL

Source sequence(s)

U20342

UniProtKB/TrEMBL

Q91592

Conserved Domains (5) summary

smart00225
Location:37 → 143

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:230 → 428

Ion_trans; Ion transport protein

pfam02214
Location:37 → 136

BTB_2; BTB/POZ domain

pfam03521
Location:471 → 755

Kv2channel; Kv2 voltage-gated K+ channel

pfam07885
Location:341 → 422

Ion_trans_2; Ion channel