ulk3 unc-51 like kinase 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ulk3provided by ZNC
Official Full Name: unc-51 like kinase 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-070410-33
See related: AllianceGenome:ZFIN:ZDB-GENE-070410-33
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:162196
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in autophagosome organization; peptidyl-serine phosphorylation; and protein autophosphorylation. Predicted to act upstream of or within autophagy and protein phosphorylation. Predicted to be active in autophagosome. Orthologous to human ULK3 (unc-51 like kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (5616274..5642061)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (5680829..5771988)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G47876 (e-PCR)
- UniSTS:108644

G38972 (e-PCR)
- UniSTS:32364

G39108 (e-PCR)
- UniSTS:61344

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase ULK3

NP_001082941.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089472.1 → NP_001082941.1 serine/threonine-protein kinase ULK3

See identical proteins and their annotated locations for NP_001082941.1

Status: PROVISIONAL

Source sequence(s)

BC134920

UniProtKB/TrEMBL

A4IG43

Conserved Domains (3) summary

smart00220
Location:14 → 237

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14121
Location:18 → 266

STKc_ULK3; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3

cl00299
Location:276 → 350

MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...