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    ZNF888 zinc finger protein 888 [ Homo sapiens (human) ]

    Gene ID: 388559, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF888provided by HGNC
    Official Full Name
    zinc finger protein 888provided by HGNC
    Primary source
    HGNC:HGNC:38695
    See related
    Ensembl:ENSG00000213793 AllianceGenome:HGNC:38695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 7.4), prostate (RPKM 5.4) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF888 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52904415..52923428, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55988936..56011678, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53407668..53426681, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15057 Neighboring gene zinc finger protein 320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53379555-53380056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15059 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53425609-53426342 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53426343-53427074 Neighboring gene ZNF816-ZNF321P readthrough Neighboring gene ZNF888 antisense RNA 1 Neighboring gene zinc finger protein 321, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53445795-53446619 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53447445-53448268 Neighboring gene uncharacterized LOC124904761

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
    2. SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk. Lukinović V, et al. Cancer Discov, 2022 Sep 2. PMID 35819319, Free PMC Article
    3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 888
    Names
    CTD-2331H12.6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310127.2 → NP_001297056.1  zinc finger protein 888 isoform b

      See identical proteins and their annotated locations for NP_001297056.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.
      Source sequence(s)
      AC010487
      Consensus CDS
      CCDS86801.1
      UniProtKB/Swiss-Prot
      A0A1W2PQ69, P0CJ79
      Conserved Domains (4) summary
      COG5048
      Location:324 → 708
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:284 → 308
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001384652.1 → NP_001371581.1  zinc finger protein 888 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC010487
      Conserved Domains (4) summary
      COG5048
      Location:343 → 727
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319 → 339
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:26 → 67
      KRAB; KRAB box
      pfam13465
      Location:303 → 327
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001384653.1 → NP_001371582.1  zinc finger protein 888 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.
      Source sequence(s)
      AC010487
      Consensus CDS
      CCDS86801.1
      UniProtKB/Swiss-Prot
      A0A1W2PQ69, P0CJ79
      Conserved Domains (4) summary
      COG5048
      Location:324 → 708
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:284 → 308
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001384654.1 → NP_001371583.1  zinc finger protein 888 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform c.
      Source sequence(s)
      AC010487
      Conserved Domains (3) summary
      COG5048
      Location:288 → 672
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:264 → 284
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:248 → 272
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001384655.1 → NP_001371584.1  zinc finger protein 888 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform c.
      Source sequence(s)
      AC010487
      Conserved Domains (3) summary
      COG5048
      Location:288 → 672
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:264 → 284
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:248 → 272
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001384656.1 → NP_001371585.1  zinc finger protein 888 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform c.
      Source sequence(s)
      AC010487
      Conserved Domains (3) summary
      COG5048
      Location:288 → 672
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:264 → 284
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:248 → 272
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001393938.1 → NP_001380867.1  zinc finger protein 888 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC010487
      Consensus CDS
      CCDS86801.1
      UniProtKB/Swiss-Prot
      A0A1W2PQ69, P0CJ79
      Related
      ENSP00000491567.1, ENST00000638862.2
      Conserved Domains (4) summary
      COG5048
      Location:324 → 708
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:284 → 308
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      52904415..52923428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438803.1 → XP_047294759.1  zinc finger protein 888 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      55988936..56011678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320968.1 → XP_054176943.1  zinc finger protein 888 isoform X2

    2. XM_054320969.1 → XP_054176944.1  zinc finger protein 888 isoform X3

      UniProtKB/Swiss-Prot
      A0A1W2PQ69, P0CJ79
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CJ79.2 GenPept UniProtKB/Swiss-Prot:P0CJ79

    Gene LinkOut

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