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    WIT1 WPP domain-interacting protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831010, updated on 15-Feb-2024

    Summary

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    Gene symbol
    WIT1
    Gene description
    WPP domain-interacting protein 1
    Primary source
    Araport:AT5G11390
    Locus tag
    AT5G11390
    See related
    TAIR:AT5G11390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2I11.280; F2I11_280; WPP domain-interacting protein 1
    Summary
    Encodes one of the WPP domain-interacting proteins (WIT1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WIT1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells.
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    Genomic context

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    See WIT1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (3633649..3636934)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene FBD / Leucine Rich Repeat domains containing protein Neighboring gene 1-deoxy-D-xylulose 5-phosphate synthase 3 Neighboring gene Protein kinase superfamily protein Neighboring gene Protein kinase superfamily protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myosin XI-i links the nuclear membrane to the cytoskeleton to control nuclear movement and shape in Arabidopsis. Tamura K, et al. Curr Biol, 2013 Sep 23. PMID 23973298
    2. Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP. Zhao Q, et al. Plant Cell, 2008 Jun. PMID 18591351, Free PMC Article
    3. Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1. Zhou X, et al. Nucleus, 2015. PMID 25759303, Free PMC Article
    4. WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1. Brkljacic J, et al. Plant Physiol, 2009 Sep. PMID 19617588, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HSC70-1 and the WPP-domain proteins play a role in facilitating WIT1 nuclear envelope targeting. [WIT1]
      Title: WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121177.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WPP domain-interacting protein 1
    NP_196700.2
    • WPP domain-interacting protein 1 (WIT1); BEST Arabidopsis thaliana protein match is: WPP domain-interacting protein 2 (TAIR:AT1G68910.1); Has 69833 Blast hits to 39390 proteins in 2372 species: Archae - 1132; Bacteria - 10633; Metazoa - 34082; Fungi - 6202; Plants - 3742; Viruses - 161; Other Eukaryotes - 13881 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3633649..3636934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121177.4 → NP_196700.2  WPP domain-interacting protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196700.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L7E5, Q9LFL8
      UniProtKB/TrEMBL
      A0A178UMG7, A0A5S9Y3K5, A0A654G052
      Conserved Domains (2) summary
      COG1196
      Location:245 → 585
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:81 → 397
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L7E5.2

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