Genome

Macaca mulatta (Rhesus monkey) Rhesus macaque is an important animal model for many human diseases including AIDS Lineage: Eukaryota[15557]; Metazoa[7782]; Chordata[3579]; Craniata[3544]; Vertebrata[3544]; Euteleostomi[3500]; Mammalia[873]; Eutheria[699]; Euarchontoglires[338]; Primates[190]; Haplorrhini[138]; Catarrhini[64]; Cercopithecidae[45]; Cercopithecinae[30]; Macaca[10]; Macaca mulatta[1]

Primates are the closest evolutionary relatives to humans and represent important animal models to study human biology and disease. The rhesus macaque, Macaca mulatta, is the most widely used primate organism for research. Their similarity to humans makes them invaluable models to study neuroscience, behavior, reproduction, AIDS, pharmacology, More...and more. The genome sequence of the rhesus macaque will lead to new and more informative studies of macaque models of human disease.

Alternate naming systems have been devised for the rhesus macaque chromosomes. NCBI follows the conventional system of naming the rhesus macaque autosomes in order of decreasing size. A table displays an alternate system of naming rhesus macaque chromosomes and the homologies between human, great ape, and rhesus macaque chromosomes. Less...

Summary Sequence data:  genome assemblies: 15; sequence reads: 11  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 3067.26  median protein count: 17802  median GC%: 41.072 NCBI Annotation Release:  103 Publications (limited to 20 most recent records) Structurally divergent and recurrently mutated regions of primate genomes. Mao Y, et al. bioRxiv 2023 Mar 7 Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance. Cirelli KM, et al. Cell 2019 May 16 A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct 2014 Oct 14 Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes. Hughes JF, et al. Nature 2012 Feb 22 Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol 2011 Oct 16 Evolutionary and biomedical insights from the rhesus macaque genome. Rhesus Macaque Genome Sequencing and Analysis Consortium, et al. Science 2007 Apr 13 Unparalleled complexity of the MHC class I region in rhesus macaques. Otting N, et al. Proc Natl Acad Sci U S A 2005 Feb 1 Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys. Gokey NG, et al. Aging Cell 2004 Oct More...  Representative (genome information for reference and representative genomes) Reference genome:   Macaca mulatta Mmul_10 Submitter: The Genome Institute at Washington University School of Medicine Loc Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr 1 NC_041754.1 CM014336.1 223.62 41.9 6,799 16 99 1,693 3,932 705 Chr 2 NC_041755.1 CM014337.1 196.2 39.8 4,105 - 6 1,092 2,200 407 Chr 3 NC_041756.1 CM014338.1 185.29 40.8 3,836 - 17 1,282 2,435 431 Chr 4 NC_041757.1 CM014339.1 169.96 39.7 3,315 - 142 1,057 2,320 450 Chr 5 NC_041758.1 CM014340.1 187.32 38.3 2,681 - 2 924 1,714 329 Chr 6 NC_041759.1 CM014341.1 179.09 39.7 2,802 - 17 1,078 1,946 373 Chr 7 NC_041760.1 CM014342.1 169.87 41.6 4,319 - 29 1,661 2,804 480 Chr 8 NC_041761.1 CM014343.1 145.68 40.3 2,485 - 6 789 1,504 266 Chr 9 NC_041762.1 CM014344.1 134.12 41.8 3,156 - 2 857 1,587 288 Chr 10 NC_041763.1 CM014345.1 99.52 45.7 3,374 - - 902 1,834 229 Chr 11 NC_041764.1 CM014346.1 133.07 41.1 3,621 - 9 921 2,014 345 Chr 12 NC_041765.1 CM014347.1 130.04 39.8 2,469 - 4 756 1,404 280 Chr 13 NC_041766.1 CM014348.1 108.74 41.2 2,300 - 4 707 1,332 211 Chr 14 NC_041767.1 CM014349.1 128.06 41.8 4,203 - 12 884 2,202 314 Chr 15 NC_041768.1 CM014350.1 113.28 41.8 2,697 - 4 729 1,466 242 Chr 16 NC_041769.1 CM014351.1 79.63 45.8 3,537 1 31 789 1,880 223 Chr 17 NC_041770.1 CM014352.1 95.43 38.7 1,208 - 4 531 845 152 Chr 18 NC_041771.1 CM014353.1 74.47 40.1 1,159 1 - 459 715 119 Chr 19 NC_041772.1 CM014354.1 58.32 48.4 4,137 - 7 685 1,963 201 Chr 20 NC_041773.1 CM014355.1 77.14 44.8 2,578 3 27 556 1,363 150 Chr X NC_041774.1 CM014356.1 153.39 39.5 2,511 1 6 719 1,743 480 Chr Y NC_027914.1 CM003438.1 11.75 40.1 118 - - 47 102 39 MT NC_005943.1 - 0.02 43.2 13 2 22 - 37 - Un - . - 117.34 41.9 554 37 6 505 965 283 Chromosomes Click on chromosome name to open Genome Data Viewer External Resources BAC Mapping at the Bioinformatics Research Lab Baylor College of Medicine CHORI BAC Library IPBIR Macaque-Human Synteny Blocks National Primate Research Centers Primate Cytogenetics Primate Info Net UC Davis SNP browser Washington University Genome Sequencing Center White Paper