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| Status |
Public on Nov 01, 2018 |
| Title |
Expression data from mouse Malignant Mesothelioma (MM) tumors and normal tissues |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
With the goal of designing a universal vaccine that can be used to target MM in mice, we analyzed expression of all the mRNA produced by different MM tumors and normal tissues.
Our hypothesis was that antigens highly expressed in MM tumors can be used as target for vaccination, as long the expression of those antigens is extremely low in all normal mouse tissues.
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| Overall design |
mRNA was analyzed in two tumors originated from two different MM cell lines injected in BALB/c mice, CRH5 and EOH6. These cells were previously generated by injecting asbestos or erionite in the same strain of mice. For the normal tissues, we have analyzed antigen expression in lungs and kidneys isolated from naïve BALB/c mice.
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| Contributor(s) |
Bertino P, Menor M, Khadka VS, Deng Y |
| Citation(s) |
31428586 |
| Submission date |
Oct 31, 2018 |
| Last update date |
Aug 27, 2019 |
| Contact name |
Pietro Bertino |
| E-mail(s) |
pbertino@hawaii.edu
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| Phone |
808 450 9618
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| Organization name |
University of Hawaii
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| Department |
Cell and Molecular Biology
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| Street address |
651 Ilalo St., BSB222
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| City |
Honolulu |
| State/province |
HI |
| ZIP/Postal code |
96813 |
| Country |
USA |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA503108 |
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