|
| Status |
Public on Nov 14, 2018 |
| Title |
Foxo signaling declines with age |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We performed RNA-seq for WT and foxo mutant flies, by combining with Dr. Baihua's foxo chip-seq data, we found 101 foxo-repressed and 300 foxo-activated genes.
By analyzing expression change of these genes during age, we found foxo-repressed genes became activated, while foxo-activated genes became repressed, suggesting foxo signaling declines with age.
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| Overall design |
Find potential foxo-regulated genes by comparing transcriptome differences between WT and foxo mutant flies, analyze their changes with age using RNA-sequencing data performed at 3d, 15d, 30d and 45d age of WT flies.
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| Contributor(s) |
Wu X, Liu N |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 13, 2018 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Xiaofen Wu |
| E-mail(s) |
xiaofenwu@sioc.ac.cn
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| Organization name |
Chinese Academy of Sciences
|
| Department |
Shanghai Institute of Organic Chemistry
|
| Street address |
345 Lingling Rd
|
| City |
Shanghai |
| ZIP/Postal code |
200032 |
| Country |
China |
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| Platforms (2) |
| GPL16479 |
Illumina MiSeq (Drosophila melanogaster) |
| GPL17275 |
Illumina HiSeq 2500 (Drosophila melanogaster) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA505319 |
| SRA |
SRP168430 |
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