|
| Status |
Public on Oct 26, 2020 |
| Title |
Disrupted mitochondrial function in aged human dermal fibroblasts |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Skin undergoes changes in structure and function with age, including a shift in metabolic programs. This is particularly evident relative to mitochondrial function in skin cells. Dermal fibroblasts have been known to accumulate damage caused by both external and internal stressors, leading to altered bioenergetics that limits efficient synthesis of ATP and NAD+. To better understand the changes in mitochondrial function with age, metabolic profiles and transcriptomic profiles of primary dermal fibroblasts from varying aged donors were analysed.
|
| |
|
| Overall design |
Primary dermal fibroblasts from 5 “young” (median age 24 ± 4.8 SD) and 5 “old” (median age 70.4 ± 15.8) Caucasian male donors were subjected to microarray profiling on the GeneTitan U219 array platform.
|
| |
|
| Contributor(s) |
Oblong JE, Birch-Machin MA |
| Citation(s) |
32990346 |
| Submission date |
May 29, 2019 |
| Last update date |
Oct 26, 2020 |
| Contact name |
Joe Sherrill |
| E-mail(s) |
sherrill.jd@pg.com
|
| Phone |
5136222038
|
| Organization name |
Procter and Gamble
|
| Street address |
8700 Mason-Montgomery Rd
|
| City |
Mason |
| State/province |
Ohio |
| ZIP/Postal code |
45040 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13667 |
[HG-U219] Affymetrix Human Genome U219 Array |
|
| Samples (10)
|
|
| Relations |
| BioProject |
PRJNA545351 |
Less...
More...