 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Jun 29, 2020 |
| Title |
Expression data from Patient-derived tumor models (PDX) establish from bone metastases and match human breast primary tumor. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
A significant proportion of patients with oestrogen receptor (ER) positive breast cancers (BC) develop resistance to endocrine treatments (ET) and relapse with metastatic disease. Bone is the most common metastatic site in ER+ patients, however bone metastases are technically challenging to biopsy and analyse. Difficulties concern both tumour tissue acquisition and techniques for analysis and RNA extractions. Patient-derived xenografts (PDX) of BC bone metastases have not been reported yet. For the first time we established PDX models from bone metastatic biopsies of patients progressing on ET and treated by vertebroplasty. PDX models were analysed at transcriptomic level and compared to patient’s early primary tumours to identify new therapeutic targets associated with endocrine resistance in the metastatic setting.
Identification of activated signalling pathways in bone metastasis by comparative transcriptomic analyses of the bone metastasis derived PDX compared to the patients' primary breast tumor.
|
| |
|
| Overall design |
Microarrays of 8 PDX of bone metastasis samples and 4 matched patients’ breast tumor samples. No replicate.
|
| |
|
| Contributor(s) |
Montaudon E, Marangoni E, Tariq Z |
| Citation(s) |
32792481, 37452026 |
| Submission date |
Mar 09, 2020 |
| Last update date |
Sep 12, 2023 |
| Contact name |
Elisabetta Marangoni |
| Organization name |
Institut Curie
|
| Street address |
26 rue d'Ulm
|
| City |
Paris |
| ZIP/Postal code |
75005 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL11532 |
[HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version] |
|
| Samples (11)
|
|
| Relations |
| BioProject |
PRJNA611590 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE146661_RAW.tar |
42.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...