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| Status |
Public on Jun 19, 2020 |
| Title |
Gene expression profiles in BV2 cells with or without PGC-1α overexpression after LPS stimulation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
PGC-1α overexpression in microglia protects against ischemia-induced brain damage in mice. To investigate the underlying mechanism of PGC-1α in vitro, we have employed whole mRNA microarray expression profiling as a discovery platform to identify genes with the potential to change the BV2 cells function. Indeed, PGC-1α overexpression alters the gene expression profiles of BV2 cells, this revealed that PGC-1α could inhibit the production of IL-1β and pro-inflammatory cytokines.
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| Overall design |
BV2 cells with or without PGC-1α overexpression were treated with LPS, then the samples were processed to perform microarray analysis.
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| Contributor(s) |
Han B, Hao J |
| Citation(s) |
33771213 |
| Submission date |
Jun 18, 2020 |
| Last update date |
Apr 05, 2021 |
| Contact name |
Bin Han |
| E-mail(s) |
hanbin1128@163.com
|
| Organization name |
Tianjin Medical University General Hospital
|
| Street address |
154 Anshan Road, Heping District
|
| City |
Tianjin |
| ZIP/Postal code |
300052 |
| Country |
China |
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| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA640374 |
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