 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Jan 28, 2010 |
| Title |
Gene expression analyses of ovarian clear cell cancer cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
A variety of human cancers demonstrate alterations in microRNA expression. We hypothesized that regulatory defects in microRNAs play a central early role in organizing the molecular changes involved in ovarian cancer (OvCa). Using both gene arrays and deep sequencing, we comprehensively profiled mRNA and microRNA expression, respectively, in human clear cell epithelial OvCa cell lines and short-term primary cultures of normal ovarian surface epithelium. We expected that over-expression of a specific microRNA would lead to lower expression of its mRNA targets, and under-expression of a specific microRNA would lead to higher expression of its target genes. Using our expression data in conjunction with established in silico algorithms, we found putative microRNA:mRNA functional pairs.
Keywords: two group comparison; gene expression profiling
|
| |
|
| Overall design |
We generated gene expression profiles of a panel of ten OvCa clear cell cell lines, along with six independent normal ovarian surface epithelium (NOSE) cultures.
|
| |
|
| Contributor(s) |
Creighton C, Matzuk M, Gunaratne P, Anderson M, Nagaraja A |
| Citation(s) |
20081105 |
| Submission date |
Jun 12, 2009 |
| Last update date |
Aug 16, 2018 |
| Contact name |
Chad Creighton |
| E-mail(s) |
creighto@bcm.tmc.edu
|
| Organization name |
Baylor College of Medicine
|
| Department |
Biostatistics, Ducan Cancer Center
|
| Street address |
One Baylor Plaza, Mail Stop: BCM305
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
|
| Samples (16)
|
| GSM416672 |
NOSE cell culture, biological rep4 |
| GSM416673 |
NOSE cell culture, biological rep5 |
| GSM416674 |
NOSE cell culture, biological rep6 |
| GSM416675 |
ES2 clear cell culture, subconfluent |
| GSM416676 |
KK clear cell culture, confluent |
| GSM416677 |
OVAS clear cell culture, confluent |
| GSM416678 |
OVISE clear cell culture, subconfluent |
| GSM416679 |
OVMANA clear cell culture, confluent |
| GSM416680 |
OVSAYO clear cell culture, confluent |
| GSM416681 |
OVTOKO clear cell culture, confluent |
| GSM416682 |
RMG1 clear cell culture, confluent |
| GSM416683 |
SMOV2 clear cell culture, subconfluent |
| GSM416684 |
TOV21G clear cell culture, confluent |
|
| This SubSeries is part of SuperSeries: |
| GSE16574 |
Gene expression analyses of putative miRNA targets in ovarian clear cell cancer cell lines |
|
| Relations |
| BioProject |
PRJNA122757 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE16570_RAW.tar |
16.7 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...