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| Status |
Public on Jul 05, 2011 |
| Title |
GAS M49: wild type vs Δralp3 mutant |
| Platform organism |
Streptococcus pyogenes NZ131 |
| Sample organism |
Streptococcus pyogenes M49 591 |
| Experiment type |
Expression profiling by array
|
| Summary |
GAS is a highly virulent Gram-positive bacterium. For the successful infection GAS express many virulence factors, which are clustered together with transcriptional regulators in distinct genomic regions. Ralp3 is a central regulator of the ERES region. In this study, we investigated the role of Ralp3 in GAS pathogenesis.
To characterize the Ralp3 regulatory function on the whole genome level, GAS M49 wild type and Äralp3 mutant strains were comprehensively compared by two colour microarray analysis. Samples were taken from cultures in the transition phase.
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| Overall design |
One condition experiment, wild type vs Δralp3. Biological replicates: 4 wild type and 4 mutant replicates per array.
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| Contributor(s) |
Siemens N, Fiedler T, Normann J, Klein J, Münch R, Patenge N, Kreikemeyer B |
| Citation(s) |
22544273 |
| Submission date |
Jul 05, 2011 |
| Last update date |
Aug 02, 2012 |
| Contact name |
Nikolai Siemens |
| E-mail(s) |
nikolai.siemens@uni-rostock.de
|
| Phone |
00493814945939
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| Organization name |
University of Rostock
|
| Department |
IMIKRO
|
| Lab |
Kreikemeyer
|
| Street address |
Schillingallee 70
|
| City |
Rostock |
| State/province |
MV |
| ZIP/Postal code |
18057 |
| Country |
Germany |
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| Platforms (1) |
| GPL13816 |
Agilent-025553 Spym49N131_01 Custom Array GE 8x15K (Probe Name version) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA143401 |
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