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| Status |
Public on May 22, 2018 |
| Title |
MicroRNA (miRNA) expression profiling of blood leukocytes of Parkinson's disease (PD) patients pre- and post-deep brain stimulation treatment and of healthy control volunteers |
| Platform organism |
synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Parkinson's disease (PD) is a prevalent, multifaceted neurodegenerative disease caused by mostly unknown factors. MicroRNAs (miRNAs) are small (~21 nucleotides long) RNAs that regulate up to hundreds of target genes. To study the role of miRNAs in PD and following surgical brain electrical stimulation treatment response, the expression profiling of miRNAs in peripheral blood leukocyte cells of PD patients pre- deep brain stimulation (DBS) and post-DBS both on electrical stimulation, and following a short one-hour electrical stimulation cessation, as well as of healthy control volunteers, were examined.
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| Overall design |
Total RNA was extracted from the blood leukocytes of 3 PD patients in three states: pre-DBS, post-DBS on electrical stimulation and following one hour off electrical stimulation, and of 3 healthy control volunteers. miRNA expression was examined.
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| Contributor(s) |
Soreq L, Bergman H, Israel Z, Soreq H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 31, 2012 |
| Last update date |
May 22, 2018 |
| Contact name |
Lilach Soreq |
| E-mail(s) |
l.soreq@ucl.ac.uk
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| Phone |
+44 07938689793
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| Organization name |
UCL
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| Department |
Molecular Neuroscience
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| Lab |
Prof. John Hardy
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| Street address |
Queen Square
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| City |
London |
| ZIP/Postal code |
WC1N 3BG |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL8786 |
[miRNA-1] Affymetrix Multispecies miRNA-1 Array |
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| Samples (13)
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| Relations |
| BioProject |
PRJNA167759 |
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