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| Status |
Public on Sep 01, 2006 |
| Title |
Androgen-starved LNCaP cells treated with gedunin and androgen, androgen alone, or vehicle alone for 24h |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Gedunin is a natural product that affects LNCaP androgen-signalling by 24h
We used microarrays to detail the androgen-responsive program of gene expression affected by gedunin treatment at 24h
Keywords: drug treatment
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| Overall design |
LNCaP cells were grown to 50% confluency and deprived of androgen, and subsequently treated with gedunin plus androgen, androgen alone, or vehicle alone for 24h prior to direct Trizol lysis and RNA isolation
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| Contributor(s) |
Hieronymus H, Golub TR |
| Citation(s) |
17010675 |
| Submission date |
Aug 11, 2006 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Haley Hieronymus |
| E-mail(s) |
haley@broad.mit.edu
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| URL |
http://www.broad.mit.edu/cgi-bin/cancer/publications/pub_menu.cgi
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| Organization name |
Broad Institute of Harvard and MIT
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| Street address |
7 Cambridge Center
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| City |
CAMBRIDGE |
| State/province |
MA |
| ZIP/Postal code |
02142 |
| Country |
USA |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (9)
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| GSM127036 |
LNCaP cells treated with 1nM R1881 and 20uM gedunin for 24h, biol repl 1 |
| GSM127037 |
LNCaP cells treated with 1nM R1881 and 20uM gedunin for 24h, biol repl 2 |
| GSM127038 |
LNCaP cells treated with 1nM R1881 and 20uM gedunin for 24h, biol repl 3 |
| GSM127039 |
Androgen-starved LNCaP cells, treated with ethanol and DMSO for 24h, biol repl 1 (gedunin control) |
| GSM127040 |
Androgen-starved LNCaP cells, treated with ethanol and DMSO for 24h, biol repl 2 (gedunin control) |
| GSM127041 |
Androgen-starved LNCaP cells, treated with ethanol and DMSO for 24h, biol repl 3 (gedunin control) |
| GSM127042 |
Androgen-starved LNCaP cells, treated with 1nM R1881 and DMSO for 6h, biol repl 1 (gedunin) |
| GSM127043 |
Androgen-starved LNCaP cells, treated with 1nM R1881 and DMSO for 6h, biol repl 2 (gedunin) |
| GSM127044 |
Androgen-starved LNCaP cells, treated with 1nM R1881 and DMSO for 6h, biol repl 3 (gedunin) |
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| Relations |
| BioProject |
PRJNA96161 |
| Supplementary data files not provided |
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