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Series GSE71270 Query DataSets for GSE71270
Status Public on Dec 06, 2016
Title Creb overexpression induces leukemia in zebrafish by blocking myeloid differentiation process
Organism Danio rerio
Experiment type Expression profiling by array
Summary To examine the role of CREB overexpression in hematopoiesis, we created a model of leukemia in zebrafish by overexpressing the human CREB in the myeloid hematopoietic lineage. Whole transcriptome analysis of kidney-marrow revealed 171 genes differently expressed between CREB- and control-zebrafish (five per group). Interestingly, the integration of this signature with human deposited data revealed that this tumor resembled a human AML at transcriptome level.
Overall design Gene expression analysis of kidney marrow from CREB-zebrafish and zebrafish controls (five animals per group).
Contributor(s) Borga C, Tregnago C, Pigazzi M, Basso G
Citation(s) 27118402
Submission date Jul 23, 2015
Last update date Jan 25, 2018
Contact name Chiara Borga
Organization name University of Padua
Street address Corso Stati Uniti,4
City Padova
ZIP/Postal code 35127
Country Italy
Platforms (1)
GPL1319 [Zebrafish] Affymetrix Zebrafish Genome Array
Samples (10)
GSM1831675 Kidney marrow_CREB-zebrafish_1
GSM1831676 Kidney marrow_CREB-zebrafish_2
GSM1831677 Kidney marrow_CREB-zebrafish_3
BioProject PRJNA290733

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71270_RAW.tar 18.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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