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| Status |
Public on Apr 25, 2016 |
| Title |
Expression data from murine fibrotic liver tissues and normal liver tissues |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Long noncoding RNAs (lncRNAs) play important roles in various biological processes; however, few have been identified that regulate hepatic stellate cells (HSCs) activation and the progression of liver fibrosis. To identify the possible roles of lncRNAs in regulating liver fiboris and the potential of lncRNAs as molecular markers for liver fiboris, we systematically analyzed the regulation of lncRNAs and mRNAs in a mouse model of carbon tetrachloride (CCl4)-induced liver fibrogenesis by microarray analysis, which revealed a panel of lncRNAs and mRNAs that were specifically regulated in livers of mice undergoing hepatic fibrosis.
To identify the possible roles of lncRNAs in regulating liver fiboris and the potential of lncRNAs as molecular markers for liver fiboris,we determined the lncRNA and mRNA expression profiles in the livers of fibrotic mice and normal mice by lncRNA and mRNA microarrays.
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| Overall design |
The lncRNA expression profile along with mRNA expression profile of five liver tissues from Balb/c mice treated with CCl4 for 6 weeks and five liver tissues from Balb/c mice treated with oil for 6 weeks were analyzed by Affymetrix GeneChip Mouse Exon 1.0 ST Array.
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| Contributor(s) |
Hong W, Han T, Zhang K |
| Citation(s) |
28747678, 31281502, 31695787, 33311456 |
| Submission date |
Apr 25, 2016 |
| Last update date |
Dec 22, 2020 |
| Contact name |
Kun Zhang |
| E-mail(s) |
zhangkun@tmu.edu.cn
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| Phone |
022-83336819
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| Organization name |
Tianjin medical university
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| Department |
Department of Histology and Embryology
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| Street address |
Qixiangtai Road NO.22
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| City |
Tianjin |
| ZIP/Postal code |
300070 |
| Country |
China |
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| Platforms (1) |
| GPL6096 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version] |
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| Samples (10)
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| GSM2131445 |
mouse fibrotic liver tissue, biological rep1 |
| GSM2131446 |
mouse fibrotic liver tissue, biological rep2 |
| GSM2131447 |
mouse fibrotic liver tissue, biological rep3 |
| GSM2131448 |
mouse fibrotic liver tissue, biological rep4 |
| GSM2131449 |
mouse fibrotic liver tissue, biological rep5 |
| GSM2131450 |
mouse normal liver tissue, biological rep1 |
| GSM2131451 |
mouse normal liver tissue, biological rep2 |
| GSM2131452 |
mouse normal liver tissue, biological rep3 |
| GSM2131453 |
mouse normal liver tissue, biological rep4 |
| GSM2131454 |
mouse normal liver tissue, biological rep5 |
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| Relations |
| BioProject |
PRJNA319475 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE80601_RAW.tar |
192.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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