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Sample GSM225441 Query DataSets for GSM225441
Status Public on Jan 03, 2008
Title Methyl mercury 24h
Sample type RNA
 
Channel 1
Source name mRNA from zebrafish embryos that were exposed to Methyl mercury 24h
Organism Danio rerio
Characteristics whole body mRNA
Strains: 200-800 zebrafish from AB*,AB2O2,AB2O2 Golden and AB2O2 Leo
whole body mRNA
Strains: 200-800 zebrafish from AB*,AB2O2,AB2O2 Golden and AB2O2 Leo
Biomaterial provider Fish Facility at the Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe
Treatment protocol Acrylamide (CH2=CHCONH2), Aroclor 1254 (PCB), Arsenic(III) Oxide (As2O3), tBHQ (tert-Butylhydroquinone (CH3)3CC6H3-1,4-(OH)2), Cadmiumchloride (CdCl2.2H2O), 4-Chloroaniline (ClC6H4NH2), DDT (1,1-Bis-(4-Chlorphenyl)-2,2,2-Trichlorethan (ClC6H4)2CHCCl3), Lead (II)chloride (PbCl2), Methylmercurychloride (CH3ClHg), TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) and Valproic acid (CH3(CH2)4CO2H) were purchased from Sigma-Aldrich. Zebrafish wild type strains AB, ABO and Tuebingen were kept and bred. Embryos were grown in embryo medium (60 ug/ml Instant Ocean, Red Sea Fish Pharm Ltd.) Different numbers of embryos were exposed to the chemicals: between 4 to 24 hpf (600 embryos), 24 to 48 hpf (400 embryos) and 96 to 120 hpf (200 embryos). Embryo medium alone (Cd, Hg, Pb, As, VA, AA) or 0.2 % ethanol in embryo medium (tBHQ , 4CA, PCB, DDT) or 0.5% DMSO, 28mg/l toluene in embryo medium (TCDD) were used as vehicle controls. The toxin concentrations were adjusted in such a way that embryo death was minimal. The few dead embryos were discarded before preparation of RNA.
Growth protocol as described in Westerfield 1993
Extracted molecule polyA RNA
Extraction protocol 1) Total RNA was isolated using the Nucleospin RNA L Kit (Macherey-Nagel, Dueren, Germany). 2) mRNA was extracted with the Ambion Purist Kit (Austin, TX).
Label Cy5
Label protocol Labeled cDNA was synthesized from 1-2 ug mRNA using the Amersham direct cDNA labeling kit (Amersham Europe, Freiburg, Germany).
 
Channel 2
Source name mRNA from zebrafish embryos that were not exposed to a toxic environment
Organism Danio rerio
Characteristics Strains: 200-800 zebrafish from AB*,AB2O2,AB2O2 Golden and AB2O2 Leo
whole body mRNA
Biomaterial provider Fish Facility at the Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe
Treatment protocol Acrylamide (CH2=CHCONH2), Aroclor 1254 (PCB), Arsenic(III) Oxide (As2O3), tBHQ (tert-Butylhydroquinone (CH3)3CC6H3-1,4-(OH)2), Cadmiumchloride (CdCl2.2H2O), 4-Chloroaniline (ClC6H4NH2), DDT (1,1-Bis-(4-Chlorphenyl)-2,2,2-Trichlorethan (ClC6H4)2CHCCl3), Lead (II)chloride (PbCl2), Methylmercurychloride (CH3ClHg), TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) and Valproic acid (CH3(CH2)4CO2H) were purchased from Sigma-Aldrich. Zebrafish wild type strains AB, ABO and Tuebingen were kept and bred. Embryos were grown in embryo medium (60 ug/ml Instant Ocean, Red Sea Fish Pharm Ltd.) Different numbers of embryos were exposed to the chemicals: between 4 to 24 hpf (600 embryos), 24 to 48 hpf (400 embryos) and 96 to 120 hpf (200 embryos). Embryo medium alone (Cd, Hg, Pb, As, VA, AA) or 0.2 % ethanol in embryo medium (tBHQ , 4CA, PCB, DDT) or 0.5% DMSO, 28mg/l toluene in embryo medium (TCDD) were used as vehicle controls. The toxin concentrations were adjusted in such a way that embryo death was minimal. The few dead embryos were discarded before preparation of RNA.
Growth protocol as described in Westerfield 1993
Extracted molecule polyA RNA
Extraction protocol 1) Total RNA was isolated using the Nucleospin RNA L Kit (Macherey-Nagel, Dueren, Germany).
2) mRNA was extracted with the Ambion Purist Kit (Austin, TX).
Label Cy3
Label protocol Labeled cDNA was synthesized from 1-2 ug mRNA using the Amersham direct cDNA labeling kit (Amersham Europe, Freiburg, Germany).
 
 
Hybridization protocol 1) Removal of unincorporated nucleotides over Microcon 30 spin columns (Millipore, Bedford, MA).
2) The concentrated probes were hybridized to the microarray in 1xDIG Easy-Hyb buffer (Hoffmann-La Roche, Basel, CH) overnight at 42 C.
3) Cover slips were removed from the slides by flushing with 4xSSC.
4) Slides were washed in pre-warmed wash buffer 1 (2xSSC, 0.1% SDS) for 5 minutes at 42 C.
5) Washing in buffer 2 (0.1xSSC, 0.1% SDS) for 10 minutes at room temperature.
6) Washing in 0.1xSSC four times for 1 min at room temperature.
7) The slides were briefly dipped into 0.01xSSC at room temperature.
8) Centrifugation for 7 min at 800 rpm in an Eppendorf 5810R centrifuge.
Scan protocol 1) Scanned on an GenePix 4000B dual-laser scanner from Molecular Devices
2) Both channels (532 nm for Cy3 and 635 nm for Cy5) were scanned in parallel
3) Data was stored as 16-bit TIFF files
4) The channels for Cy3 and Cy5 were balanced in each scan for approximately the same intensity profile.
5) Each array was scanned three times (low, medium and high scan) with different signal amplification factors (voltage settings of the photomultiplier tubes), but with the same laser power.
6) Raw data was retrieved with GenePix Pro 6.0 software from Axon Instruments .
7) Data processing was performed
8) The absolute intensity values span the range from 0 to 65536.
9) The scans were performed with a resolution of 10 um.
Description This file contains all technological and biological replicates (i.e. from the same and different biological source, repspectively) that were performed with this particular toxin at this particular concentration. The Dye-Swap Designe was utilised.
Data processing 1) Raw data are retrieved with GenePix 2) Quality control on spot level 3) Local background correction. 4) Averaging of the two spots for each gene. 5) Consensus signals are calculated from low, medium and high scan based on a Least Squares Algorithm. 6) Log transformation. 7) locally weighted regression smoother (LOESS). 8) Scaling to a common MAD. 9) t-test 10) adjustment of p-values for multiplicity 11) Quality control on array level.
 
Submission date Aug 29, 2007
Last update date Jan 02, 2008
Contact name Jessica Legradi
Organization name Karlsruhe Institute of Technology
Department Institute of Toxicology and Genomics ITG
Lab Straehle
Street address Hermann-von-Helmholtz-Platz 1
City Eggenstein-Leopoldshafen
State/province Baden-Wuerttemberg
ZIP/Postal code 76344
Country Germany
 
Platform ID GPL4603
Series (1)
GSE9357 biosensor-series

Data table header descriptions
ID_REF spot/gene id (numbered from 1-34992)
VALUE normalized log naturalis ratios (M or M.bar value) (test/reference)
res_A.bar averaged log naturalis average
res_M.var variance of VALUE
res_M.se standard error of VALUE
res_par.state1 Check for reliability of p-value and fold change: A.bar + 0.5 * M.bar
res_par.state2 Check for reliability of p-value and fold change: A.bar - 0.5 * M.bar
res_t test statistic of t-test for this gene
res_t.reg test statistic of regularized t-test for this gene
res_fc fold change
res_p.value p-value for t-test
res_p.adj adjusted p-value for t-test
res_wilcox.stat test statistic for wilcoxon test
res_p.value.adj.wil adjusted p-value for wilcoxon test
res_good.arrays numnber of good flags (after quality control) for this gene
res_comment1 Comment if FC is not reliable
res_comment2 Comment if t and regularized t-values are not reliable
NA.
norm_flag_Array1 flag if spot is good (1) or bad (0)
norm_flag_Array2
norm_flag_Array3
norm_flag_Array4
norm_flag_Array5
norm_flag_Array6
norm_flag_Array7
norm_flag_Array8
norm_R_Array1 Red signal after normalization
norm_R_Array2
norm_R_Array3
norm_R_Array4
norm_R_Array5
norm_R_Array6
norm_R_Array7
norm_R_Array8
norm_G_Array1 Green signal after normalization
norm_G_Array2
norm_G_Array3
norm_G_Array4
norm_G_Array5
norm_G_Array6
norm_G_Array7
norm_G_Array8
norm_M_Array1 M value after normalization
norm_M_Array2
norm_M_Array3
norm_M_Array4
norm_M_Array5
norm_M_Array6
norm_M_Array7
norm_M_Array8
norm_A_Array1 A value after normalization
norm_A_Array2
norm_A_Array3
norm_A_Array4
norm_A_Array5
norm_A_Array6
norm_A_Array7
norm_A_Array8
norm_C_Array1 Normalization constant that will be added to signal
norm_C_Array2
norm_C_Array3
norm_C_Array4
norm_C_Array5
norm_C_Array6
norm_C_Array7
norm_C_Array8
avg_R_Array1 Red channel value after averaging of scans
avg_R_Array2
avg_R_Array3
avg_R_Array4
avg_R_Array5
avg_R_Array6
avg_R_Array7
avg_R_Array8
avg_G_Array1 Green channel value after averaging of scans
avg_G_Array2
avg_G_Array3
avg_G_Array4
avg_G_Array5
avg_G_Array6
avg_G_Array7
avg_G_Array8
avg_flag_Array1 Flag (good/bad spot) value after averaging of scans
avg_flag_Array2
avg_flag_Array3
avg_flag_Array4
avg_flag_Array5
avg_flag_Array6
avg_flag_Array7
avg_flag_Array8

Data table
ID_REF VALUE res_A.bar res_M.var res_M.se res_par.state1 res_par.state2 res_t res_t.reg res_fc res_p.value res_p.adj res_wilcox.stat res_p.value.adj.wil res_good.arrays res_comment1 res_comment2 NA. norm_flag_Array1 norm_flag_Array2 norm_flag_Array3 norm_flag_Array4 norm_flag_Array5 norm_flag_Array6 norm_flag_Array7 norm_flag_Array8 norm_R_Array1 norm_R_Array2 norm_R_Array3 norm_R_Array4 norm_R_Array5 norm_R_Array6 norm_R_Array7 norm_R_Array8 norm_G_Array1 norm_G_Array2 norm_G_Array3 norm_G_Array4 norm_G_Array5 norm_G_Array6 norm_G_Array7 norm_G_Array8 norm_M_Array1 norm_M_Array2 norm_M_Array3 norm_M_Array4 norm_M_Array5 norm_M_Array6 norm_M_Array7 norm_M_Array8 norm_A_Array1 norm_A_Array2 norm_A_Array3 norm_A_Array4 norm_A_Array5 norm_A_Array6 norm_A_Array7 norm_A_Array8 norm_C_Array1 norm_C_Array2 norm_C_Array3 norm_C_Array4 norm_C_Array5 norm_C_Array6 norm_C_Array7 norm_C_Array8 avg_R_Array1 avg_R_Array2 avg_R_Array3 avg_R_Array4 avg_R_Array5 avg_R_Array6 avg_R_Array7 avg_R_Array8 avg_G_Array1 avg_G_Array2 avg_G_Array3 avg_G_Array4 avg_G_Array5 avg_G_Array6 avg_G_Array7 avg_G_Array8 avg_flag_Array1 avg_flag_Array2 avg_flag_Array3 avg_flag_Array4 avg_flag_Array5 avg_flag_Array6 avg_flag_Array7 avg_flag_Array8
1 0.095273452220412 6.30245077098412 0.0218029988373221 0.0940256940839972 6.35008749709433 6.25481404487391 1.82498281718043 1.01327039538044 1.09995960039959 0.344666769064016 0.462871491521648 29 0.231859878582269 8 FALSE TRUE TRUE TRUE TRUE FALSE FALSE TRUE 6.8868843457806 5.84784975458652 5.16412261635643 6.14195902372615 6.06809151578394 6.75086156394872 5.77492874089745 5.93339345963417 6.3894291013179 6.20607940395313 0.136022781831887 0.0729210136890648 -0.769270843277737 -0.247470077591753 -0.137987888169187 6.81887295486466 5.81138924774198 5.5487580379953 6.26569406252203 6.13708545986853 -0.315822258174605 -0.481573457435114 -0.320352620821939 -0.383297375986547 -0.052869385644223 836.288138260682 272.343197337355 149 383.872449916056 420.589299943079 1001.01793179513 409.818947053418 443 721.31633748688 509.033635945704 FALSE TRUE TRUE TRUE TRUE FALSE FALSE TRUE
2 0.0421324891298586 7.26383721152495 0.0422172644415164 0.082873701042998 7.28490345608988 7.24277096696002 0.579985407079457 0.50839396092614 1.04303266008635 0.626803399570197 0.722815204249945 20 0.926346009036145 8 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 7.99254705991764 7.68090921362773 6.68285360858616 6.54873844985682 7.22138753583585 6.10758272924587 6.4982354298215 7.5596404498848 8.0374757146899 7.82367833865905 6.70653596411635 6.89980551190407 7.3444775717706 7.00607859093794 6.96523185874061 7.45244379138274 -0.0449286547722665 -0.142769125031312 -0.0236823555301842 -0.351067062047246 -0.123090035934755 -0.898495861692066 -0.466996428919110 0.107196658502063 8.01501138730377 7.75229377614339 6.69469478635125 6.72427198088044 7.28293255380322 6.5568306600919 6.73173364428105 7.50604212063377 -0.5761697578878 -0.208109020407879 -0.226949914341705 -0.167665306686048 -0.305887931944804 -0.306739632177113 -0.504477580188987 -0.134637462171659 2218.2240582909 1952.47817451067 712.926729468757 642.203862753671 1174.31886585928 385.373468889283 515.943178239476 1794.21291770122 4128.05071886969 2773.13256157292 915.99501387114 1078.83622021928 1803.38645052455 1286.20127761619 1363.03709746471 1844.12930277434 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
3 0.126459125551486 7.02551389421348 0.0234782055529692 0.0758461746968376 7.08874345698923 6.96228433143774 2.33433250546818 1.66731052761661 1.13480306577860 0.139389412201266 0.223985778460080 31 0.132180156657963 8 FALSE TRUE TRUE TRUE TRUE FALSE TRUE TRUE 7.40500547525916 6.7010676094815 6.52123989811057 7.04926907778293 5.87928622863709 6.666388909912 7.61782104459108 6.7246102948647 6.91024461833997 7.02676532084464 6.26871672585835 6.81667248479261 -0.212815569331928 -0.0235426853831993 -0.389004720229398 0.0225037569382864 -0.389430497221257 -0.150283574880614 7.51141325992512 6.7128389521731 6.71574225822527 7.03801719931379 6.07400147724772 6.7415306973523 -0.226890615915051 -0.224738294230232 -0.167042198118535 -0.31669030845587 -0.533349789748521 -0.106988670658270 1467.85901730091 726.834251870753 624.979468659051 983.30950046324 273.858440880773 744.635304664151 2278.48574083770 931.67071482184 1089.81770421752 1319.63501699827 689.103598744182 963.109218408669 FALSE TRUE TRUE TRUE TRUE FALSE TRUE TRUE
4 0.0331577585419516 8.61678222025446 0.00643317279493199 0.0456298625530488 8.63336109952544 8.60020334098349 1.16927738425258 0.726667946970096 1.03371360352946 0.491009196141819 0.603406398517754 26 0.428722653493296 8 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 9.26873216399606 8.5541705383598 7.71759556541724 8.35361866097245 8.86861091776539 8.3824009595454 8.33705581912272 8.88680184750772 9.30169069338826 8.73467968995742 7.80600378203307 8.43711469504753 8.92813455954062 8.7163709788394 8.5490968404285 9.02453092738164 -0.0329585293921999 -0.180509151597619 -0.08840821661583 -0.0834960340750801 -0.0595236417752377 -0.333970019294002 -0.212041021305785 -0.137729079873916 9.28521142869216 8.6444251141586 7.76179967372516 8.39536667801 8.898372738653 8.54938596919239 8.44307632977561 8.95566638744468 -0.543065228929683 -0.148592798658434 -0.151659740294839 -0.133892961939465 -0.258964831473415 -0.309112749122526 -0.491941211489462 -0.126698194575866 8080.42338706216 4816.84360611142 2083.41925428733 3970.59874624252 6242.45305579465 3743.75570218621 3265.22911853296 6791.67414279368 14374.6757351035 6694.0616353916 2648.72494982487 4934.76916657745 8583.67116155778 7121.8824136379 6601.60081395292 8847.40986611005 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
5 0.0506570856203615 6.17988759674229 0.0839652553923784 0.150406364724199 6.20521613955247 6.15455905393211 0.428219084935493 0.336801475876714 1.05196209849547 0.749943207810241 0.821037880223263 13 0.793489016425886 6 t and regul. t values unreliable FALSE TRUE TRUE TRUE TRUE FALSE TRUE FALSE 5.99272435086181 5.86044438352668 5.72429437165766 6.01152815533113 5.73942775433318 6.58200107245384 6.0823484043684 6.27896655685033 6.47082594249933 5.56133119066141 -0.589276721592029 -0.221904020841721 -0.554672185192674 -0.459297787168205 0.178096563671772 6.28736271165782 5.97139639394754 6.00163046425399 6.24117704891523 5.6503794724973 -0.475405177637374 -0.420524867228549 -0.202947213649903 -0.387631407385271 -0.794187004736743 315.772419302438 284.343197337355 276.668700923959 336.202094755754 209 915.713608464265 540.562810237529 590.187429562302 784.18239987442 387 FALSE TRUE TRUE TRUE TRUE FALSE TRUE FALSE
6 0.0915488316111882 6.84315191184613 0.21009781874813 0.156763800967289 6.88892632765172 6.79737749604053 0.564920100529168 0.583992165578399 1.09587028849784 0.577551332823953 0.681332217590714 25 0.509950319780722 8 t and regul. t values unreliable FALSE TRUE TRUE TRUE TRUE FALSE TRUE TRUE 7.34750724892265 6.03527285732872 6.14064211774378 6.32688744843293 5.7212521390581 6.41741070796501 7.82233743915006 6.43950153381822 6.69171551760838 6.45274033193711 6.4384833312637 7.11852145914526 -0.474830190227415 -0.404228676489497 -0.551073399864602 -0.125852883504183 -0.717231192205598 -0.701110751180247 7.58492234403635 6.23738719557347 6.41617881767608 6.38981389018502 6.0798677351609 6.76796608355514 -0.221222147252682 -0.325638497964816 -0.149193731751298 -0.361394007180256 -0.531862047400808 -0.106606488248295 1389.77365577915 355.119235718850 430.972917571364 466.935178909316 234 580.626366951233 2787.63407363412 736.803166669704 868.104746858668 760.090371080171 816 1302.21859876089 FALSE TRUE TRUE TRUE TRUE FALSE TRUE TRUE
7 0.0183062442498499 6.35252337047653 0.0509384258417745 0.106777888115730 6.36167649260145 6.3433702483516 0.229414828823144 0.17144227679432 1.01847483069608 0.868726804120231 0.909426444377884 20 0.926346009036145 8 t and regul. t values unreliable FALSE TRUE TRUE TRUE TRUE FALSE TRUE TRUE 6.53022350994613 5.96897492192828 5.96581922075218 6.13104000635194 5.53960065160537 6.20890528181436 6.94471459211372 6.0532659831145 6.2628022777422 6.4060042826152 5.40828936556871 6.40712625380634 -0.414491082167588 -0.0842910611862168 -0.296983056990012 -0.274964276263264 0.131311286036664 -0.198220971991976 6.73746905102993 6.01112045252139 6.11431074924719 6.26852214448357 5.47394500858704 6.30801576781035 -0.339947070224079 -0.40448687981319 -0.176166877945089 -0.382774857376003 -0.966709692514128 -0.0771192382576878 578.390921498798 319.491759627476 357 379.80295458422 157 478.351425753642 1229.8999790639 520.874652721541 573 733.180347084963 362 629.978614099239 FALSE TRUE TRUE TRUE TRUE FALSE TRUE TRUE
8 0.115144869707799 8.56161334474436 0.122820669755097 0.115846827753431 8.61918577959826 8.50404090989046 0.92929554578574 0.99394063644862 1.12203597482210 0.353359845584007 0.47175763894222 24 0.595874279592138 8 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 9.23137104132619 8.85617797800778 7.90699546362152 7.96979496571013 8.41355111448974 7.64350268662975 7.4623413095973 8.25099738388877 9.41267393358884 9.29168619152284 8.33238680038372 8.50567891587965 8.74855851023047 8.58868061349529 7.69935322455283 8.55135863331584 -0.181302892262650 -0.435508213515058 -0.4253913367622 -0.535883950169516 -0.335007395740728 -0.945177926865538 -0.237011914955534 -0.300361249427071 9.32202248745752 9.07393208476531 8.11969113200262 8.23773694079489 8.5810548123601 8.11609165006252 7.58084726707506 8.4011780086023 -0.542577026311579 -0.131760623749183 -0.139116864887398 -0.139748032809639 -0.26565338955969 -0.3277447147397 -0.500211832557652 -0.138111610616586 7786 6570.18760675881 2533.70270397311 2697.06911465414 3947.05266930511 1771.58575145206 1355.91989641948 3575.79060374950 16058 11586.1593287652 4455.72574707772 5300.48143540926 7196.7528125026 6326.81969394063 2834.04171843371 5543.68343418875 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
9 -0.169924354252004 9.8101037198433 0.0550352849263926 0.081762520698491 9.7251415427173 9.8950658969693 -2.04870775824392 -2.07826706907216 -1.18521519143952 0.0762800504451031 0.132559848668440 5 0.132180156657963 8 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 10.1190144375302 9.64376708177936 9.10100180485279 9.67951248627104 10.1107924947729 9.74333335063497 9.18836588384908 9.84353039435086 10.5459972397624 9.60909451704303 9.5284310223424 9.94218315238894 10.4911687878594 10.0844087993753 9.75770535406724 9.79434892274095 -0.426982802232138 0.0346725647363319 -0.427429217489622 -0.262670666117894 -0.380376293086445 -0.341075448740333 -0.569339470218158 0.0491814716099138 10.3325058386463 9.6264307994112 9.3147164135976 9.81084781933 10.3009806413161 9.91387107500513 9.47303561895816 9.8189396585459 -0.53906140689843 -0.097697017701061 -0.0827130234278791 -0.0804143156653077 -0.216249022065111 -0.286901353161318 -0.468504934993637 -0.102298468467862 18948.5697756348 14689.9457023481 8601.09924396252 15356.672182422 22085.3105108725 14763.0493752346 7739.66292854795 17896.8707859076 49787.9339358846 15645.569015721 14325.3723470207 21641.9818226754 40106.4841166304 27663.2328334994 21850.0354197598 18873.1990873585 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
10 0.0656313759998627 7.40112841697126 0.0284499374034188 0.0724594265545323 7.43394410497119 7.36831272897133 1.10056537547211 0.905767256527612 1.06783301572882 0.395165386155548 0.513160661781153 25 0.509950319780722 8 TRUE TRUE TRUE TRUE TRUE FALSE TRUE TRUE 8.08216477986867 7.81421707859278 6.8533499527187 6.89308594529095 7.37451600250555 6.50835157735736 6.90349066203043 8.3065440960617 8.05660461101114 7.00712512446104 7.24097286129965 7.48941546282483 6.57310646872096 7.26136756473235 -0.224379316193032 -0.242387532418355 -0.153775171742339 -0.347886916008702 -0.114899460319288 -0.0647548913636018 -0.357876902701923 8.19435443796519 7.93541084480196 6.93023753858987 7.0670294032953 7.43196573266519 6.54072902303916 7.08242911338139 -0.564822923162849 -0.190180729509764 -0.204903903779384 -0.166429049555293 -0.300121768032303 -0.509045531563777 -0.120355339040091 2440 2250.99296097906 854.826052464857 906.754209460898 1372.59051264198 520 937.590224340488 5372 3469.25438692109 1223.62993460708 1516.54103545083 2078.65503724813 923 1512.53939258842 TRUE TRUE TRUE TRUE TRUE FALSE TRUE TRUE
11 0.189918222499198 5.80452581637762 0.31044749610877 0.239227439012776 5.89948492762722 5.70956670512802 0.59038210284994 0.793881434683816 1.20915071229066 0.51049479010016 0.621416325582161 4 0.848606350643472 3 t and regul. t values unreliable FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE
12 0.179353455726828 7.84318770088756 0.0981848728726157 0.106919356393800 7.93286442875097 7.75351097302415 1.61894632908683 1.6774647900633 1.19644355926812 0.137351557516972 0.221198715971736 27 0.356653620352251 8 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 8.76986413876964 8.23289887672672 7.55379955390681 7.28341065430411 7.75867103629502 6.780732518646 6.67526058023971 7.2763518690123 8.71542315665482 8.60173517484656 7.66076577023116 7.78715153694095 8.02284765007163 7.8665016768979 6.87221787506193 7.70795941805162 0.0544409821148283 -0.368836298119840 -0.106966216324357 -0.503740882636834 -0.264176613776609 -1.08576915825190 -0.196957294822219 -0.431607549039321 8.74264364771223 8.41731702578664 7.60728266206899 7.53528109562253 7.89075934318333 7.32361709777195 6.77373922765082 7.49215564353196 -0.543353716406713 -0.158961678648668 -0.161779591641642 -0.159025476875152 -0.295250036174861 -0.319556206833670 -0.502128406022676 -0.134749399345987 4905.86781327982 3475.23727902768 1759.71960163319 1344.66194154386 2020.39035789371 750.661197807946 616.585116550912 1351.5091951275 7999.22559105385 5891.20602747912 2302.28080765056 2608.84865693057 3535.01445757291 3060.33534960139 1240.51522715828 2381.13874785955 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
13 0.130261595084713 11.5806357994269 0.0149031075670618 0.0563244369825495 11.6457665969692 11.5155050018845 3.01802593397095 2.31270123703270 1.13912633420157 0.0539715933276703 0.097721928682699 34 0.0455523772495001 8 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 12.4888746112778 11.7047186318000 11.1606787423012 11.3990364663929 11.9497475023163 11.5632284363464 10.9930250699201 11.2561690351021 12.4613272174354 11.7190735159761 11.0142167436856 11.6004246745133 11.9720428158985 11.8544618860982 10.6840895575495 11.4825691074076 0.027547393842423 -0.0143548841761108 0.146461998615637 -0.201388208120441 -0.0222953135821852 -0.291233449751768 0.308935512370582 -0.226400072305528 12.4751009143566 11.7118960738880 11.0874477429934 11.4997305704531 11.9608951591074 11.7088451612223 10.8385573137348 11.3693690712548 -0.532162685080912 -0.0175669911895506 -0.0269219545317531 -0.0650477135809492 -0.140040473549539 -0.268735820994705 -0.43375216805648 -0.0561387319329548 203372.23904367 120082.602149529 69370.5541752812 86380.1004675732 144311.186682082 91937.1550976032 47865.4383741563 75214.5269746273 336855.239266533 123977.702710932 61554.4680359718 112752.285909777 169746.776011691 160946.903330644 54228.7040129903 99771.5621576632 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
14 0.077879587645386 8.58962045151086 0.00215876516573507 0.0409516668627967 8.62856024533356 8.55068065768817 4.74095612380712 1.90174402195426 1.08099248598248 0.0989519098103435 0.166291673618458 36 0.0162994872406392 8 t and regul. t values unreliable TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 9.3594701640094 9.04319809037942 8.28756299935664 8.16052365124123 8.63788887512194 8.40418617020552 7.61948130539609 8.2497133749201 9.34522360102371 9.15891793431683 8.27100653810964 8.3560057656364 8.66272093788813 8.6743965636 7.66527935939413 8.33978415615575 0.0142465629856829 -0.115719843937404 0.0165564612470077 -0.195482114395162 -0.0248320627661893 -0.270210393394482 -0.0457980539980403 -0.0900707812356615 9.35234688251655 9.10105801234812 8.27928476873314 8.25826470843881 8.65030490650504 8.53929136690276 7.64238033239511 8.29474876553792 -0.542082621744218 -0.129971979121935 -0.134047777516629 -0.138979323733826 -0.265667620531747 -0.309381443577502 -0.501830648514743 -0.136972103060236 8852.26690922995 7928.44417712518 3716.50545000217 3265.06186470836 4939.67621670143 3825.69507389352 1585.3587178878 3573.23748864704 15006.8930604964 10136.5595416672 4179.84911036292 4561.90431149779 6604.81857105185 6830.050083371 2741.31958455223 4483.99741494705 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
15 -0.0508718109651798 7.4640079869619 0.022072468712801 0.0671676200143405 7.43857208147931 7.4894438924445 -0.968493558907255 -0.757385939152206 -1.05218800567294 0.473537527032325 0.587256349089705 11 0.509950319780722 8 t and regul. t values unreliable TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 8.1430644869551 7.51406438892837 6.94807573448065 7.59087089975314 7.81968745157161 7.31850442106795 6.83507600583718 7.60471810576604 8.12872727325204 7.43281490076608 6.97145043140022 7.54170739291845 7.91002202919537 7.70808530368489 6.90718966371883 7.33150855143048 0.0143372137030624 0.0812494881622871 -0.0233746969195634 0.0491635068346868 -0.0903345776237588 -0.389580882616944 -0.0721136578816484 0.273209554335556 8.13589588010358 7.47343964484722 6.95976308294043 7.5662891463358 7.8648547403835 7.51329486237642 6.871132834778 7.46811332859826 -0.567983678346372 -0.229449697148912 -0.202925841090061 -0.158797787894922 -0.295661724943344 -0.322599038173243 -0.498339695833672 -0.134938661784271 2589.11823723048 1634.90428503363 940.68921489655 1828.90371924594 2147.06396270459 1283.31891306944 724.807540272474 1876.65980259875 4503.99073350563 1896.07217550620 1179.57956361190 2040.81861225905 3158.50120442563 2615.95581664173 1282.23446610502 1634.31311567557 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
16 0.0346935449939437 9.24493628955523 0.0353509451154989 0.0694498109551792 9.2622830620522 9.22758951705826 0.521907042638037 0.499548443930739 1.03530238658047 0.632709330487053 0.728090137213989 21 0.844298602080624 8 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 9.99882957113147 9.81917654836356 8.90732704679656 8.89415363145906 9.10088392164697 8.8686782638199 7.98239686329363 8.82672698051601 10.0945468662598 10.0166373225593 9.10812935734815 9.22684197879559 9.39817372288987 9.29518830486359 8.30714176985046 8.91595564868597 -0.0957172951283615 -0.197460774195770 -0.200802310551597 -0.33268834733652 -0.297289801242897 -0.426510041043682 -0.324744906556827 -0.0892286681699598 10.0466882186957 9.91790693546144 9.00772820207236 9.06049780512732 9.24952882226842 9.08193328434175 8.14476931657204 8.87134131460099 -0.539876788677796 -0.0884417792858689 -0.0956376239335263 -0.100854086090235 -0.240291741499714 -0.30169981863581 -0.497426226573266 -0.129133620810669 16795.9182874655 17587.7103002355 7041.019364964 6930.77271195032 7948.49634604507 6110.89397266871 2284.00040936386 6387.89562588833 31713.1043410779 23408.5872893299 9470.60593967125 10692.1918651911 13606.7271612792 12657.9178352424 5197.09390091288 7946.78290007347 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
17 0.05078787664291 7.0729464223416 0.0139669880126783 0.0684185265317669 7.09834036066306 7.04755248402014 1.21549637889111 0.742311757025768 1.05209969469199 0.482058641712257 0.594536726025494 28 0.293471959807626 8 t and regul. t values unreliable TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 8.08314635523804 7.23384284369755 6.53157077111804 7.140425770256 7.41761964566743 7.08176250926922 6.1275903978414 6.48800388369393 7.85380345869581 7.44570099136218 6.76902440641066 7.2530049515086 7.46105719970313 7.17743824224545 6.060399740138 6.56438356179347 0.22934289654223 -0.211858147664631 -0.237453635292611 -0.112579181252592 -0.0434375540357079 -0.0956757329762272 0.0671906577033994 -0.0763796780995336 7.96847490696692 7.33977191752986 6.65029758876435 7.1967153608823 7.43933842268528 7.12960037575733 6.0939950689897 6.5261937227437 -0.579391690312168 -0.238695275156679 -0.232934856799046 -0.159672656023938 -0.299959924439448 -0.313302109569281 -0.527918444486613 -0.0998410738627365 2424.66951129486 1229.66272828507 611.003900359621 1165.1317412728 1433.16373765658 1017.50766909717 352 625.207345027315 3440.93771176901 1929.56260936008 977.982557305852 1529.72197091971 2020.37246482067 1531.63228252733 558 745.685626155895 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
18 0.0770602339160235 8.01568285526776 0.00782315787146306 0.0502401863844554 8.05421297222577 7.97715273830975 2.46424718588207 1.53383654523755 1.08010713351563 0.168939391704339 0.263015091409424 32 0.0970299665348342 8 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 9.0386079800389 8.39990932201426 7.69185958823616 7.70693525881176 8.35168463479916 7.85214622592173 6.95013417831245 7.55320191514028 9.04855944729334 8.51435464492832 7.56181334038898 7.95398240005324 8.33090098110711 8.1087683187241 7.07271194274488 7.59042565311607 -0.00995146725444007 -0.114445322914054 0.130046247847183 -0.247047141241479 0.0207836536920515 -0.256622092802381 -0.122577764432428 -0.0372237379757876 9.04358371366612 8.45713198347129 7.62683646431257 7.8304588294325 8.34129280795314 7.98045727232292 7.01142306052866 7.57181378412818 -0.545567203866261 -0.156538315067452 -0.160107887929735 -0.151749738767611 -0.271272093084823 -0.329778775883595 -0.491664896540299 -0.134653471889029 6411.34513982385 4111.89867065336 2021.92568213075 2061.23457274372 3699.85381449836 2180.38520121710 815.908103238834 1782.68365492283 11173.9789840430 5391.74199827125 2083.63091769216 3071.30327314112 4753.02733475041 3919.25830379143 1508.00730242794 2116.99389865754 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
19 0.0163976632943579 6.09784027281522 0.000393608671795734 0.178032794239473 6.1060391044624 6.08964144116804 1.16886575033761 0.0921047347731972 1.01653284284059 0.941529273555025 0.960524558024415 3 0.620909929732415 2 FC is not reliable t and regul. t values unreliable t and regul. t values unreliable FALSE TRUE FALSE FALSE TRUE FALSE FALSE FALSE 6.25244630457043 5.60925626325679 6.25765655141256 5.69085701677356 -0.00521024684212684 -0.081600753516777 6.25505142799149 5.65005664001518 -0.487266238255668 -0.565152315357559 407 205.753758268110 666 392.852087936716 FALSE TRUE FALSE FALSE TRUE FALSE FALSE FALSE
20 0.051695388014907 9.14482533355923 0.0202094438147331 0.0580170342800043 9.17067302756669 9.11897763955178 1.02853627247138 0.891038100386388 1.05305492050298 0.402495085890073 0.520509997268376 25 0.509950319780722 8 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 10.0581548245993 9.44700946241496 8.63923846571882 8.6997173386932 9.38821500948278 8.98082902068233 8.24609232588737 8.90123805446417 10.2140664572844 9.40814280623621 8.55741503399396 9.15668410718978 9.46191493996954 9.32842995318639 8.46782961512774 8.96356255281408 -0.155911632685061 0.0388666561787408 0.0818234317248602 -0.456966768496589 -0.0736999304867517 -0.347600932504055 -0.221737289240363 -0.0623244983499176 10.1361106409419 9.42757613432558 8.5983267498564 8.92820072294149 9.42506497472616 9.15462948693436 8.35696097050755 8.93240030363912 -0.539118931125787 -0.109567924122706 -0.111447085905116 -0.110101519212303 -0.233154228882239 -0.300398054037440 -0.493511420142338 -0.127414378925304 17829.2448830265 11994.7640016539 5342.85227241207 5679.77318720074 10632.15198179 6840.59498991825 2978.98112244342 6887.96431263395 35725.7116508464 12873.5071371633 5503.49474131511 10013.9546757977 14450.6121275376 13077.2450561040 6091.10826460367 8327.09339649647 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE

Total number of rows: 34992

Table truncated, full table size 24178 Kbytes.




Supplementary data files not provided
Processed data included within Sample table
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