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Sample GSM225456 Query DataSets for GSM225456
Status Public on Jan 03, 2008
Title Valproic acid 48h
Sample type RNA
 
Channel 1
Source name mRNA from zebrafish embryos that were exposed to Valproic acid 48h
Organism Danio rerio
Characteristics whole body mRNA
Strains: 200-800 zebrafish from AB*,AB2O2,AB2O2 Golden and AB2O2 Leo
whole body mRNA
Strains: 200-800 zebrafish from AB*,AB2O2,AB2O2 Golden and AB2O2 Leo
Biomaterial provider Fish Facility at the Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe
Treatment protocol Acrylamide (CH2=CHCONH2), Aroclor 1254 (PCB), Arsenic(III) Oxide (As2O3), tBHQ (tert-Butylhydroquinone (CH3)3CC6H3-1,4-(OH)2), Cadmiumchloride (CdCl2.2H2O), 4-Chloroaniline (ClC6H4NH2), DDT (1,1-Bis-(4-Chlorphenyl)-2,2,2-Trichlorethan (ClC6H4)2CHCCl3), Lead (II)chloride (PbCl2), Methylmercurychloride (CH3ClHg), TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) and Valproic acid (CH3(CH2)4CO2H) were purchased from Sigma-Aldrich. Zebrafish wild type strains AB, ABO and Tuebingen were kept and bred. Embryos were grown in embryo medium (60 ug/ml Instant Ocean, Red Sea Fish Pharm Ltd.) Different numbers of embryos were exposed to the chemicals: between 4 to 24 hpf (600 embryos), 24 to 48 hpf (400 embryos) and 96 to 120 hpf (200 embryos). Embryo medium alone (Cd, Hg, Pb, As, VA, AA) or 0.2 % ethanol in embryo medium (tBHQ , 4CA, PCB, DDT) or 0.5% DMSO, 28mg/l toluene in embryo medium (TCDD) were used as vehicle controls. The toxin concentrations were adjusted in such a way that embryo death was minimal. The few dead embryos were discarded before preparation of RNA.
Growth protocol as described in Westerfield 1993
Extracted molecule polyA RNA
Extraction protocol 1) Total RNA was isolated using the Nucleospin RNA L Kit (Macherey-Nagel, Dueren, Germany). 2) mRNA was extracted with the Ambion Purist Kit (Austin, TX).
Label Cy5
Label protocol Labeled cDNA was synthesized from 1-2 ug mRNA using the Amersham direct cDNA labeling kit (Amersham Europe, Freiburg, Germany).
 
Channel 2
Source name mRNA from zebrafish embryos that were not exposed to a toxic environment
Organism Danio rerio
Characteristics Strains: 200-800 zebrafish from AB*,AB2O2,AB2O2 Golden and AB2O2 Leo
whole body mRNA
Biomaterial provider Fish Facility at the Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe
Treatment protocol Acrylamide (CH2=CHCONH2), Aroclor 1254 (PCB), Arsenic(III) Oxide (As2O3), tBHQ (tert-Butylhydroquinone (CH3)3CC6H3-1,4-(OH)2), Cadmiumchloride (CdCl2.2H2O), 4-Chloroaniline (ClC6H4NH2), DDT (1,1-Bis-(4-Chlorphenyl)-2,2,2-Trichlorethan (ClC6H4)2CHCCl3), Lead (II)chloride (PbCl2), Methylmercurychloride (CH3ClHg), TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) and Valproic acid (CH3(CH2)4CO2H) were purchased from Sigma-Aldrich. Zebrafish wild type strains AB, ABO and Tuebingen were kept and bred. Embryos were grown in embryo medium (60 ug/ml Instant Ocean, Red Sea Fish Pharm Ltd.) Different numbers of embryos were exposed to the chemicals: between 4 to 24 hpf (600 embryos), 24 to 48 hpf (400 embryos) and 96 to 120 hpf (200 embryos). Embryo medium alone (Cd, Hg, Pb, As, VA, AA) or 0.2 % ethanol in embryo medium (tBHQ , 4CA, PCB, DDT) or 0.5% DMSO, 28mg/l toluene in embryo medium (TCDD) were used as vehicle controls. The toxin concentrations were adjusted in such a way that embryo death was minimal. The few dead embryos were discarded before preparation of RNA.
Growth protocol as described in Westerfield 1993
Extracted molecule polyA RNA
Extraction protocol 1) Total RNA was isolated using the Nucleospin RNA L Kit (Macherey-Nagel, Dueren, Germany).
2) mRNA was extracted with the Ambion Purist Kit (Austin, TX).
Label Cy3
Label protocol Labeled cDNA was synthesized from 1-2 ug mRNA using the Amersham direct cDNA labeling kit (Amersham Europe, Freiburg, Germany).
 
 
Hybridization protocol 1) Removal of unincorporated nucleotides over Microcon 30 spin columns (Millipore, Bedford, MA).
2) The concentrated probes were hybridized to the microarray in 1xDIG Easy-Hyb buffer (Hoffmann-La Roche, Basel, CH) overnight at 42 C.
3) Cover slips were removed from the slides by flushing with 4xSSC.
4) Slides were washed in pre-warmed wash buffer 1 (2xSSC, 0.1% SDS) for 5 minutes at 42 C.
5) Washing in buffer 2 (0.1xSSC, 0.1% SDS) for 10 minutes at room temperature.
6) Washing in 0.1xSSC four times for 1 min at room temperature.
7) The slides were briefly dipped into 0.01xSSC at room temperature.
8) Centrifugation for 7 min at 800 rpm in an Eppendorf 5810R centrifuge.
Scan protocol 1) Scanned on an GenePix 4000B dual-laser scanner from Molecular Devices
2) Both channels (532 nm for Cy3 and 635 nm for Cy5) were scanned in parallel
3) Data was stored as 16-bit TIFF files
4) The channels for Cy3 and Cy5 were balanced in each scan for approximately the same intensity profile.
5) Each array was scanned three times (low, medium and high scan) with different signal amplification factors (voltage settings of the photomultiplier tubes), but with the same laser power.
6) Raw data was retrieved with GenePix Pro 6.0 software from Axon Instruments .
7) Data processing was performed
8) The absolute intensity values span the range from 0 to 65536.
9) The scans were performed with a resolution of 10 um.
Description This file contains all technological and biological replicates (i.e. from the same and different biological source, repspectively) that were performed with this particular toxin at this particular concentration. The Dye-Swap Designe was utilised.
Data processing 1) Raw data are retrieved with GenePix 2) Quality control on spot level 3) Local background correction. 4) Averaging of the two spots for each gene. 5) Consensus signals are calculated from low, medium and high scan based on a Least Squares Algorithm. 6) Log transformation. 7) locally weighted regression smoother (LOESS). 8) Scaling to a common MAD. 9) t-test 10) adjustment of p-values for multiplicity 11) Quality control on array level.
 
Submission date Aug 29, 2007
Last update date Jan 02, 2008
Contact name Jessica Legradi
Organization name Karlsruhe Institute of Technology
Department Institute of Toxicology and Genomics ITG
Lab Straehle
Street address Hermann-von-Helmholtz-Platz 1
City Eggenstein-Leopoldshafen
State/province Baden-Wuerttemberg
ZIP/Postal code 76344
Country Germany
 
Platform ID GPL4603
Series (1)
GSE9357 biosensor-series

Data table header descriptions
ID_REF spot/gene id (numbered from 1-34992)
VALUE normalized log naturalis ratios (M or M.bar value) (test/reference)
res_A.bar averaged log naturalis average
res_M.var variance of VALUE
res_M.se standard error of VALUE
res_par.state1 Check for reliability of p-value and fold change: A.bar + 0.5 * M.bar
res_par.state2 Check for reliability of p-value and fold change: A.bar - 0.5 * M.bar
res_t test statistic of t-test for this gene
res_t.reg test statistic of regularized t-test for this gene
res_fc fold change
res_p.value p-value for t-test
res_p.adj adjusted p-value for t-test
res_wilcox.stat test statistic for wilcoxon test
res_p.value.adj.wil adjusted p-value for wilcoxon test
res_good.arrays numnber of good flags (after quality control) for this gene
res_comment1 Comment if FC is not reliable
res_comment2 Comment if t and regularized t-values are not reliable
NA.
norm_flag_Array1 flag if spot is good (1) or bad (0)
norm_flag_Array2
norm_flag_Array3
norm_flag_Array4
norm_flag_Array5
norm_flag_Array6
norm_flag_Array7
norm_flag_Array8
norm_R_Array1 Red signal after normalization
norm_R_Array2
norm_R_Array3
norm_R_Array4
norm_R_Array5
norm_R_Array6
norm_R_Array7
norm_R_Array8
norm_G_Array1 Green signal after normalization
norm_G_Array2
norm_G_Array3
norm_G_Array4
norm_G_Array5
norm_G_Array6
norm_G_Array7
norm_G_Array8
norm_M_Array1 M value after normalization
norm_M_Array2
norm_M_Array3
norm_M_Array4
norm_M_Array5
norm_M_Array6
norm_M_Array7
norm_M_Array8
norm_A_Array1 A value after normalization
norm_A_Array2
norm_A_Array3
norm_A_Array4
norm_A_Array5
norm_A_Array6
norm_A_Array7
norm_A_Array8
norm_C_Array1 Normalization constant that will be added to signal
norm_C_Array2
norm_C_Array3
norm_C_Array4
norm_C_Array5
norm_C_Array6
norm_C_Array7
norm_C_Array8
avg_R_Array1 Red channel value after averaging of scans
avg_R_Array2
avg_R_Array3
avg_R_Array4
avg_R_Array5
avg_R_Array6
avg_R_Array7
avg_R_Array8
avg_G_Array1 Green channel value after averaging of scans
avg_G_Array2
avg_G_Array3
avg_G_Array4
avg_G_Array5
avg_G_Array6
avg_G_Array7
avg_G_Array8
avg_flag_Array1 Flag (good/bad spot) value after averaging of scans
avg_flag_Array2
avg_flag_Array3
avg_flag_Array4
avg_flag_Array5
avg_flag_Array6
avg_flag_Array7
avg_flag_Array8

Data table
ID_REF VALUE res_A.bar res_M.var res_M.se res_par.state1 res_par.state2 res_t res_t.reg res_fc res_p.value res_p.adj res_wilcox.stat res_p.value.adj.wil res_good.arrays res_comment1 res_comment2 NA. norm_flag_Array1 norm_flag_Array2 norm_flag_Array3 norm_flag_Array4 norm_flag_Array5 norm_flag_Array6 norm_flag_Array7 norm_flag_Array8 norm_R_Array1 norm_R_Array2 norm_R_Array3 norm_R_Array4 norm_R_Array5 norm_R_Array6 norm_R_Array7 norm_R_Array8 norm_G_Array1 norm_G_Array2 norm_G_Array3 norm_G_Array4 norm_G_Array5 norm_G_Array6 norm_G_Array7 norm_G_Array8 norm_M_Array1 norm_M_Array2 norm_M_Array3 norm_M_Array4 norm_M_Array5 norm_M_Array6 norm_M_Array7 norm_M_Array8 norm_A_Array1 norm_A_Array2 norm_A_Array3 norm_A_Array4 norm_A_Array5 norm_A_Array6 norm_A_Array7 norm_A_Array8 norm_C_Array1 norm_C_Array2 norm_C_Array3 norm_C_Array4 norm_C_Array5 norm_C_Array6 norm_C_Array7 norm_C_Array8 avg_R_Array1 avg_R_Array2 avg_R_Array3 avg_R_Array4 avg_R_Array5 avg_R_Array6 avg_R_Array7 avg_R_Array8 avg_G_Array1 avg_G_Array2 avg_G_Array3 avg_G_Array4 avg_G_Array5 avg_G_Array6 avg_G_Array7 avg_G_Array8 avg_flag_Array1 avg_flag_Array2 avg_flag_Array3 avg_flag_Array4 avg_flag_Array5 avg_flag_Array6 avg_flag_Array7 avg_flag_Array8
1 0.0433663472282836 6.81203505257646 0.185105875528763 0.168727809288311 6.8337182261906 6.79035187896232 0.246898451404127 0.257019559556908 1.04432040866705 0.807405127868785 0.877818201965645 11 1 6 TRUE TRUE FALSE FALSE FALSE TRUE FALSE TRUE 6.48960705365952 6.5446231237429 6.70092714257925 6.66014568813716 7.1703601885434 7.23589548886803 6.54544028076649 6.80503520442055 -0.680753134883885 -0.69127236512513 0.155486861812762 -0.144889516283396 6.82998362110146 6.89025930630547 6.62318371167287 6.73259044627885 -0.0376150997538355 -0.136691051054162 -0.00674692019323 -0.0636986256764425 646 649.548559802501 810.42085149408 756.192803915637 1325 1486.59123221355 698.415180823246 931.582280436504 TRUE TRUE FALSE FALSE FALSE TRUE FALSE TRUE
2 -0.00118315181913628 7.38731593569847 0.185456910098450 0.147812715928289 7.3867243597889 7.38790751160804 -0.00777076829269834 -0.00800439807702526 -1.00118385201937 0.993836825557125 0.99617124605829 17 1 8 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE 7.06918634868536 7.99780700911456 5.26630332726823 6.08944222798542 6.84462524365597 8.2062172225887 6.24220498811247 8.2320588654152 7.37944955818825 8.35272602006039 6.71905931126511 6.70861410847521 7.24593849575369 8.073523328284 5.81066985679016 8.09117323093697 -0.310263209502886 -0.354919010945827 -1.45275598399688 -0.619171880489791 -0.401313252097714 0.132693894304715 0.431535131322319 0.140885634478227 7.2243179534368 8.17526651458748 5.99268131926667 6.39902816823031 7.04528186970483 8.13987027543635 6.02643742245132 8.16161604817608 -0.0174019398342850 -0.0426271073426798 -0.609303037263706 -0.233825648044372 -0.625100676388378 0.000142690707307315 -0.734548514520889 -0.0489890919402713 1165.01049992252 2911.70312545481 142.829528199273 392.497200205737 686.821824404686 3663.91881453098 356 3668.59604732339 1616.71328043319 4333.10465184433 1122.94595710343 921.061613499794 1916.94649900616 3208.1572405856 482 3346.49154797785 TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
3 0.235995751674654 6.9386161157529 0.183225311583816 0.16466956603307 7.05661399159023 6.82061823991558 1.35047663813986 1.43314734689505 1.26616893105789 0.211258377070638 0.346591971779971 16 0.46875 6 TRUE TRUE FALSE FALSE TRUE TRUE FALSE TRUE 6.64592818617165 6.85870039627002 6.16698342920655 6.55693266788099 7.07265027071297 7.0095257626375 7.72996501999313 6.75126164431296 6.89668183133332 7.24047788593415 -0.363597576465841 -0.871264623723116 -0.584278215106407 -0.339749163452336 -0.167827615221177 6.82772697440457 7.29433270813157 6.45912253675976 6.72680724960715 7.15656407832356 -0.0377899365324649 -0.09165066772048 -0.648661657413446 -0.0091656191699844 -0.0583581175045028 755.238216408506 909.481868799457 344.692460451433 700.889230606848 1145.35648937235 1128.24739622383 2382.22535724029 1182.74403719087 993.530380627922 1436.05772129238 TRUE TRUE FALSE FALSE TRUE TRUE FALSE TRUE
4 -0.173102623921485 7.61465051517275 0.149784258815875 0.134690288770614 7.52809920321201 7.7012018271335 -1.26507291358670 -1.28519008683907 -1.18898811744644 0.239611700963719 0.382504226282959 9 0.392886014551334 8 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE 7.50175712986144 8.43010968801502 6.29532496865433 6.87418854953541 6.6414170933279 8.5800973197452 8.10101765671649 7.91002619908563 8.65192257760881 7.1473270270792 6.77248134222322 7.2567958870921 7.91825054735869 8.00268122981259 -0.40826906922419 -0.221812889593790 -0.852002058424867 0.101707207312192 -0.615378793764202 0.66184677238651 0.0983364269039027 7.70589166447353 8.54101613281192 6.72132599786677 6.82333494587932 6.94910649021 8.24917393355195 8.05184944326454 0.0223346617963158 -0.0404953129788659 -0.566955697937495 -0.254287267717501 -0.629873024322973 7.91869382812407e-05 -0.0512802226907643 1831.56204959841 4491.14083295253 408.236686300738 851.538672239346 559.185120023992 5324.83451561193 3214.34069907928 2694.20612910453 5838.15577558852 1687.16498570497 991.902658622912 1942.50255829707 2746.85240159630 3066.58959245467 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE
5 0.249156902600151 6.63714963696166 0.171391027823435 0.170246096508996 6.76172808826173 6.51257118566158 1.47419355054173 1.46351022260875 1.28294331442049 0.203199192207392 0.335773806843647 18 0.266837481698390 6 FALSE TRUE FALSE TRUE FALSE TRUE FALSE TRUE 6.39053707280678 5.42859361423745 6.63955680938692 6.7302609933174 7.71940996334174 5.8521012501507 6.88037371954568 6.94319718432116 -1.32887289053497 -0.423507635913255 -0.240816910158760 -0.212936191003757 7.05497351807426 5.64034743219408 6.7599652644663 6.83672908881928 -0.115766058134564 -0.273216330690873 -0.0096235298101358 -0.0616635007314866 562.64790612639 198.73761733807 761.084998264444 811.942271117669 2385.80767169819 398.899464112028 977.682997885316 1068.51908350316 FALSE TRUE FALSE TRUE FALSE TRUE FALSE TRUE
6 0.294445426272256 6.56304610637132 0.567856393585858 0.253916661205471 6.71026881950744 6.41582339323519 1.03379534597150 1.15961443756536 1.34238170259715 0.290262317329552 0.442204048872919 20 0.554700710179236 7 TRUE TRUE FALSE TRUE TRUE TRUE FALSE TRUE 6.90872281414928 7.13715703990992 5.04030701734051 5.33941893350501 6.54999365088606 6.18851470610102 7.40757212259525 8.25061167712917 6.08486401536936 6.96106753722229 7.19279992872581 7.12118016507064 -0.498849308445976 -1.11345463721925 -1.04455699802886 -1.62164860371728 -0.642806277839752 -0.932665458969617 7.15814746837227 7.69388435851955 5.56258551635493 6.15024323536365 6.87139678980594 6.65484743558583 -0.0200165596385801 -0.0636147907096814 -0.290574531100102 -0.690420322243146 -0.00851796609257164 -0.0609406976075749 991 1218.46804097946 133.622645874983 147.556148683347 696.268016814658 472.503123407049 1665 3953.74722393138 507.832303022691 1489.62203405962 1335.49716770409 1276.21062114236 TRUE TRUE FALSE TRUE TRUE TRUE FALSE TRUE
7 0.322134958571701 6.91131225836253 0.220117045492038 0.180492003811944 7.07237973764838 6.75024477907668 1.53530980116762 1.78476027618008 1.38007101580277 0.148856328440413 0.259453110419751 13 0.318680784923256 5 FALSE TRUE FALSE FALSE FALSE TRUE FALSE TRUE 6.62606214349832 6.63563962600969 6.63081084231547 7.79290681770915 6.76207102602677 7.00666278170406 -1.16684467421084 -0.126431400017081 -0.375851939388595 7.20948448060374 6.69885532601823 6.81873681200976 -0.101966241954140 -0.00852552604495592 -0.0623513924340651 717.002281441437 758.525838134732 734.827035815543 2550.10531853591 868.123329330325 1138.9231365794 FALSE TRUE FALSE FALSE FALSE TRUE FALSE TRUE
8 -0.0642551019353068 7.87201832877724 0.265339712256174 0.174453339923879 7.8398907778096 7.9041458797449 -0.330031588685246 -0.368322566729556 -1.06636439568764 0.725278433927843 0.823243251589564 11 0.827098947947466 7 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE 7.96661465722025 8.42255609874364 5.36175944430153 6.77459150980713 7.52181985129065 8.20295070365924 8.00730781927366 8.4325327936404 9.05248404954115 6.87229060823801 7.16272231969957 8.26423092611908 8.38485629983786 8.39619377149233 -0.46591813642014 -0.629927950797515 -1.51053116393649 -0.388130809892438 -0.742411074828438 -0.181905596178624 -0.388885952218677 8.19957372543032 8.7375200741424 6.11702502626977 6.96865691475335 7.89302538870487 8.29390350174855 8.201750795383 0.0605848698597633 -0.0428555106816218 -0.596246804684304 -0.264889344428714 -0.551374432605164 0.00073828768552614 -0.0480280385977337 2971.75240203499 4452.08739810277 158.164565053304 766.739292103106 1402.66970938868 3653.0577934988 2931.57118815132 4457.04094113797 8724.6864100395 1300.38286363731 1473.16288664523 5114.92564908421 4378.61242833159 4537.84627990212 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE
9 -0.246406425056264 9.80791338854323 0.25570828460869 0.171991756067625 9.6847101760151 9.93111660107136 -1.28922479202558 -1.43266416187634 -1.27941945601235 0.201929824512853 0.334181253280068 8 0.554700710179236 7 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE 9.73748084214487 10.1177703326355 7.35261759956197 8.86299364175723 9.1039610323799 10.7383122948660 9.51934364301415 9.86158171445805 10.5185910637161 9.36162007165778 8.95044903476913 10.1315942654862 10.4816956622684 9.68155819942349 -0.124100872313185 -0.40082073108057 -2.00900247209580 -0.087455393011896 -1.02763323310633 0.256616632597587 -0.162214556409343 9.79953127830146 10.3181806981758 8.35711883560987 8.90672133826318 9.61777764893306 10.6100039785672 9.60045092121882 0.178091131660062 -0.0770720661669643 -0.529647112426361 -0.32748222331247 -0.416562598845155 0.00407741014660977 0.0113146725634443 18518.5166032390 23842.7221678094 1197.26377339417 5998.42689760181 7300.36578165591 46182.259043734 13697.9433388610 17545.2080956489 38450.504539049 15160.4240110363 9083.27551811959 30942.1795145495 35584.1985445001 15929.0674888809 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE
10 -0.0301493691421763 7.12428343258231 0.222646784541106 0.16684245679653 7.10920874801123 7.1393581171534 -0.169051502674457 -0.180705617269497 -1.03060846355919 0.862547955306195 0.914115877765897 14 1 7 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE 6.92209491151558 7.74865027385075 4.50640897944028 5.92184745316723 6.93459593809117 7.47757783422936 7.27669840389695 7.64199189758505 8.46895285246515 5.95101810008682 6.41688675672224 7.42018813146537 7.52321214150344 7.56653218227658 -0.719896986069473 -0.720302578614404 -1.44460912064655 -0.495039303555004 -0.485592193374202 -0.045634307274083 -0.289833778379626 7.28204340455031 8.10880156315795 5.22871353976355 6.16936710494473 7.17739203477827 7.5003949878664 7.42161529308677 -0.0150732988324100 -0.0462871552801053 -1.00925919954950 -0.208090520096257 -0.61744979735811 -0.0120961931960919 -0.0689726815466336 1006.82617597058 2265.40016638023 54.6953873564906 336.232267383371 754.361004633139 1757.29282747258 1397.18120805318 2099.65546717414 4876.07772164113 636.28571498536 679.211126591513 2273.13003362079 1861.72775875646 2000.23214048689 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE
11 2.05805345122271 6.70305956278144 7.73208628839279 5.67403283717008 7.83071210213178 1 1 1 FC is not reliable t and regul. t values unreliable t and regul. t values unreliable FALSE TRUE FALSE FALSE FALSE FALSE FALSE FALSE 5.91157970489972 7.49453942066315 -1.58295971576343 6.70305956278144 -0.169070968408865 339.354139262317 1956.81788510590 FALSE TRUE FALSE FALSE FALSE FALSE FALSE FALSE
12 -0.0398995191830473 7.0553134357598 0.244817870475555 0.173940666947867 7.03536367616827 7.07526319535132 -0.213351216848720 -0.229385800820264 -1.04070619792955 0.826188519494473 0.891623139469239 11 0.827098947947466 7 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE 7.21790487650333 7.76825740505346 4.63839165523150 5.88901167965338 6.48420837079779 7.07442201461575 7.23993284980119 7.96051545071545 8.41501718128118 5.82319559323147 6.4172679022162 7.26702562610153 7.27924824030563 7.56273512549759 -0.742610574212117 -0.646759776227723 -1.18480393799998 -0.528256222562824 -0.782817255303742 -0.204826225689886 -0.322802275696399 7.58921016360939 8.09163729316732 5.23079362423149 6.15313979093479 6.87561699844966 7.17683512746069 7.40133398764939 0.0147851040669792 -0.047620893503938 -1.00782799016311 -0.207169169612196 -0.634203551279116 -0.00662817745050142 -0.0687590861326156 1373.74714647555 2308.71635434204 62.4569587901477 325.521038786056 476.804519802723 1177.45184123476 1346.88972606123 2844.44400512152 4623.13177607774 559.536962104762 679.157111249671 1966.72972002435 1454.71070117837 1992.43874730633 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE
13 0.084614688533817 10.3275780522318 0.195906105353909 0.155277023008482 10.3698853964988 10.2852707079649 0.505790647637162 0.544927297641421 1.08829765233694 0.605450376413549 0.735571126014266 17 0.827098947947466 7 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE 11.4275175674509 11.2517624508219 8.16913616156527 9.2277080440524 9.40325695757217 10.4581228396735 9.58308531811945 11.0756477143453 11.7996935229048 9.38952752200664 9.7294812792381 9.9434733179636 10.3349944907004 9.78895364140555 0.351869853105606 -0.547931072082883 -1.22039136044137 -0.501773235185696 -0.540216360391429 0.123128348973050 -0.205868323286106 11.2515826408981 11.5257279868633 8.77933184178596 9.47859466164525 9.67336513776788 10.3965586651869 9.6860194797625 0.219092148804575 -0.0866666304561407 -0.503434946021454 -0.307903232879538 -0.413437384520153 0.00685427924013084 0.0126593554257149 102443.186091278 73749.4735295214 2744.67702750868 8723.3308974 9862.92705705368 34945.6745632054 14609.3205205903 57878.5217172358 139110.914244946 15386.4879131588 19602.9020038177 25596.0164317241 30686.1702333650 17723.096655082 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE
14 -0.0281060896389337 8.22826218965067 0.175479996365998 0.147719792977115 8.2142091448312 8.24231523447014 -0.177515237839566 -0.190266240376386 -1.02850479233577 0.855374658471264 0.91031843215409 15 1 7 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE 8.24789308950509 8.60957619770348 4.94112602885459 6.9519603041148 8.32556523825384 8.30097551502466 8.53536349386928 8.42488373164367 9.07478698045807 7.0187062393626 7.4635716712576 8.73087512611152 8.55870807751189 8.82533300711357 -0.176990642138582 -0.46521078275458 -2.07758021050801 -0.511611367142801 -0.405309887857679 -0.257732562487224 -0.289969513244289 8.33638841057438 8.84218158908078 5.97991613410859 7.2077659876862 8.52822018218268 8.42984179626827 8.68034825049142 0.0722897610105235 -0.0456407526205370 -0.61071011936132 -0.277686068045800 -0.485776647301313 0.00340645043576412 -0.0292352148088742 3960.15311937706 5360.19600446372 103.107379971489 909.702178974162 3237.88919871961 4034.66575258262 5017.79506674888 4397.26858557036 8933.89149594482 1516.34983134411 2003.02677951722 7893.25163327543 5203.07383631615 6904.65164238583 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE
15 0.0783196580760906 7.16293918813039 0.0744036915018776 0.116416514514336 7.20209901716844 7.12377935909235 0.759665775684735 0.67275384770643 1.08146830350031 0.526151071635813 0.67061551317405 19 0.650737919542966 7 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE 7.13495436290516 7.35708999863054 5.07727260569777 6.35624528870532 6.83059133836593 7.54648474857992 6.83599089606915 7.23794777223066 8.08863184328669 6.0986985280088 6.50854309816648 7.06088106476955 7.63853251152026 7.12354548690229 -0.102993409325501 -0.731541844656152 -1.02142592231103 -0.152297809461158 -0.230289726403615 -0.0920477629403402 -0.287554590833141 7.18645106756791 7.72286092095862 5.58798556685328 6.4323941934359 6.94573620156774 7.59250863005009 6.97976819148572 -0.0191753391585309 -0.063447085064043 -0.75563043160264 -0.237520621159528 -0.630079388684458 -0.0116660406317007 -0.058064260569658 1243.10392140022 1518.33019808842 109.887530188205 511.570281211329 675.566530990292 1883.05686671850 904.116990043903 1404.63876480511 3362.21541646120 649.701965945559 755.442302427064 1597.06166279255 2088.84285102518 1277.39434887107 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE
16 -0.0393516537684446 8.68597586991688 0.208439582839737 0.157872819042334 8.66630004303265 8.7056516968011 -0.228045712163580 -0.249261741236738 -1.04013618715579 0.81147202355917 0.880641485048146 15 1 7 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE 8.9678206056578 9.27414235496731 5.81200028634677 7.44863146160002 8.78709007315879 8.87593997546792 9.00539772840295 9.17978623656756 9.73645989324342 7.56071593901707 7.8798668322684 9.220989619636 9.11858852891532 9.3268458535333 -0.211965630909760 -0.462317538276107 -1.74871565267031 -0.431235370668377 -0.433899546477214 -0.242648553447399 -0.321448125130348 9.07380342111268 9.50530112410537 6.68635811268192 7.66424914693421 9.0040398463974 8.99726425219162 9.16612179096812 0.131902359412127 -0.051317730329963 -0.570418236693155 -0.339665748747926 -0.455810694823392 0.0212514585735980 -0.00466693523115028 8381.41291911923 10388.7990447302 251.336120298751 1449.24583631974 5214.42824994263 7234.13232729377 8127.95197153883 9080.05071435834 17363.3815398698 2555.30036997915 3132.85405475671 12694.1300783857 9026.88657041285 11261.8853008791 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE
17 0.0156182967733819 7.01440574805967 0.056986107152462 0.112083958810520 7.02221489644636 7.00659659967298 0.173100449528517 0.139344621113758 1.01574089982243 0.893737451217533 0.9352575430776 18 0.73493242752307 7 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE 7.01796038079265 7.5207813553861 5.51408546621475 6.45966138161208 6.81199923568021 7.34841900806242 6.69158734168909 7.58344309888584 7.67561853211567 5.53846211882674 6.17302147763932 7.06752220424457 7.49525656501027 7.08788457182497 -0.565482718093186 -0.154837176729572 -0.0243766526119854 0.286639903972758 -0.255522968564358 -0.146837556947852 -0.396297230135875 7.30070173983925 7.59819994375088 5.52627379252074 6.3163414296257 6.93976071996239 7.42183778653634 6.88973595675703 -0.0143210904885259 -0.0659175139489273 -0.798655340125747 -0.222860553289689 -0.630448490988692 -0.0104823439187584 -0.0597364093008062 1108.54080074727 1786.15866988546 166.460458736748 571.480924638403 663 1545.61603204293 781.893965247324 1979.50807159382 2227.3710977372 379.096120449702 536.170256997166 1608 1808.9425680097 1233.67497267291 TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE
18 0.0541079685062775 7.48888509317668 0.0106981636587279 0.0915869372112523 7.51593907742982 7.46183110892354 1.28139266918811 0.590782595791727 1.05559856740319 0.580358349232335 0.715569437199081 16 0.46875 6 TRUE TRUE TRUE TRUE TRUE TRUE FALSE FALSE 8.08483890786145 8.44531392788316 5.80436372589414 6.48165495891389 7.53168612750218 7.6791344838724 8.14370317015653 8.67063040852991 6.07805403379392 6.46938439417139 7.40682415811578 7.5848161966609 -0.0588642622950845 -0.225316480646752 -0.273690307899772 0.0122705647425004 0.124861969386400 0.0943182872115015 8.11427103900899 8.55797216820654 5.94120887984403 6.47551967654264 7.46925514280898 7.63197534026665 0.0530326889360632 -0.0405954653900637 -0.614496728990998 -0.242896307213305 -0.58353017772423 -0.0113041571101643 3332.09079504746 4559.71862330101 243.987101550662 578.365953175317 1393.98389565654 2150.55753329722 3351.57889487156 5948.70091581479 593.064047038427 728.387034540463 2205.23475480444 1979.24012587184 TRUE TRUE TRUE TRUE TRUE TRUE FALSE FALSE
19 0.0801916427606068 6.54282775209012 6.58292357347042 6.50273193070981 1.08349469169332 1 1 1 FC is not reliable t and regul. t values unreliable t and regul. t values unreliable FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE
20 0.284257267016389 8.35329699551432 0.0539879824328369 0.101152903796756 8.49542562902251 8.21116836200612 3.23677154335004 2.81017406665398 1.32877473669517 0.0307491384510559 0.0622237943950582 26 0.0924813937753722 7 TRUE TRUE TRUE TRUE TRUE TRUE FALSE FALSE 8.81049240529555 9.2271449845048 6.96029472195511 6.6655023035422 8.20314735428515 8.19693526952152 8.90797295656432 9.57031010911566 6.66254133983272 7.42030593380781 8.23119776143692 8.73942991597222 -0.0974805512687716 -0.343165124610863 0.297753382122396 -0.754803630265605 -0.0280504071517608 -0.542494646450692 8.85923268092993 9.39872754681023 6.81141803089391 7.042904118675 8.21717255786103 8.46818259274687 0.115520480131008 -0.0517729184750311 -0.560016356265601 -0.270189185548655 -0.52067493486688 0.00464256145802609 7102.85890998938 9909.59268698834 796.547325032995 685.67771269687 2815.25996677565 3638.24444969778 6975.87269550974 14708.7313871924 1035.40664055683 1911.03551118524 4873.34202851151 6229.85685781088 TRUE TRUE TRUE TRUE TRUE TRUE FALSE FALSE

Total number of rows: 34992

Table truncated, full table size 22748 Kbytes.




Supplementary data files not provided
Processed data included within Sample table
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