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    Plekhh1 pleckstrin homology, MyTH4 and FERM domain containing H1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314262, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Plekhh1provided by RGD
    Official Full Name
    pleckstrin homology, MyTH4 and FERM domain containing H1provided by RGD
    Primary source
    RGD:1308362
    See related
    Ensembl:ENSRNOG00000010650 AllianceGenome:RGD:1308362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in cytoskeleton. Orthologous to human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 89.7), Kidney (RPKM 48.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekhh1 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (103572304..103621729)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (97839288..97888712)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (102215424..102264345)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547797 Neighboring gene transmembrane protein 229B Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class H Neighboring gene branched chain ketoacid dehydrogenase kinase, pseudogene 1 Neighboring gene arginase 2 Neighboring gene vesicle transport through interaction with t-SNAREs 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family H member 1
    Names
    pleckstrin homology domain containing, family H (with MyTH4 domain) member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395591.1 → NP_001382520.1  pleckstrin homology domain-containing family H member 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HCG0, D4AA54
      Related
      ENSRNOP00000014257.8, ENSRNOT00000014257.8
      Conserved Domains (7) summary
      smart00139
      Location:824 → 978
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:680 → 783
      PH; Pleckstrin homology domain
      smart00295
      Location:991 → 1222
      B41; Band 4.1 homologues
      COG1196
      Location:15 → 177
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13282
      Location:573 → 668
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cl17171
      Location:1218 → 1320
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:988 → 1094
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      103572304..103621729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112286.2 → XP_038968214.1  pleckstrin homology domain-containing family H member 1 isoform X1

      UniProtKB/TrEMBL
      A6HCG0, D4AA54
      Conserved Domains (7) summary
      smart00139
      Location:824 → 978
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:680 → 783
      PH; Pleckstrin homology domain
      smart00295
      Location:991 → 1222
      B41; Band 4.1 homologues
      COG1196
      Location:15 → 177
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13282
      Location:573 → 668
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cl17171
      Location:1218 → 1320
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:988 → 1094
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_039112284.2 → XP_038968212.1  pleckstrin homology domain-containing family H member 1 isoform X1

      UniProtKB/TrEMBL
      A6HCG0, D4AA54
      Conserved Domains (7) summary
      smart00139
      Location:824 → 978
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:680 → 783
      PH; Pleckstrin homology domain
      smart00295
      Location:991 → 1222
      B41; Band 4.1 homologues
      COG1196
      Location:15 → 177
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13282
      Location:573 → 668
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cl17171
      Location:1218 → 1320
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:988 → 1094
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_039112288.2 → XP_038968216.1  pleckstrin homology domain-containing family H member 1 isoform X2

      UniProtKB/TrEMBL
      A6HCG0
      Conserved Domains (7) summary
      smart00139
      Location:824 → 978
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:680 → 783
      PH; Pleckstrin homology domain
      smart00295
      Location:991 → 1222
      B41; Band 4.1 homologues
      COG1196
      Location:15 → 177
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13282
      Location:573 → 668
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cl17171
      Location:1218 → 1319
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:988 → 1094
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. XM_039112283.2 → XP_038968211.1  pleckstrin homology domain-containing family H member 1 isoform X1

      UniProtKB/TrEMBL
      A6HCG0, D4AA54
      Conserved Domains (7) summary
      smart00139
      Location:824 → 978
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:680 → 783
      PH; Pleckstrin homology domain
      smart00295
      Location:991 → 1222
      B41; Band 4.1 homologues
      COG1196
      Location:15 → 177
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13282
      Location:573 → 668
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cl17171
      Location:1218 → 1320
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:988 → 1094
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    5. XM_063261930.1 → XP_063118000.1  pleckstrin homology domain-containing family H member 1 isoform X3

    6. XM_039112282.2 → XP_038968210.1  pleckstrin homology domain-containing family H member 1 isoform X1

      UniProtKB/TrEMBL
      A6HCG0, D4AA54
      Conserved Domains (7) summary
      smart00139
      Location:824 → 978
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:680 → 783
      PH; Pleckstrin homology domain
      smart00295
      Location:991 → 1222
      B41; Band 4.1 homologues
      COG1196
      Location:15 → 177
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13282
      Location:573 → 668
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cl17171
      Location:1218 → 1320
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:988 → 1094
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RNA

    1. XR_005505523.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108036.2: Suppressed sequence

      Description
      NM_001108036.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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